RESUMEN
We demonstrate the impact of the optics roughness in Öffner stretchers used in chirped pulse amplification laser chains and how it is possible to improve the temporal contrast ratio in the temporal range of 10-100 ps by adequately choosing the optical quality of the key components. Experimental demonstration has been realized in the front-end source of the multi-petawatt (PW) laser facility Apollon, resulting in an enhancement of the contrast ratio by two to three orders of magnitude.
RESUMEN
High-energy petawatt lasers require large diffraction gratings for pulse compression. As an alternative to meter-sized gratings, we demonstrate the capability of a tiled-grating system to compress multiterawatt subpicosecond laser pulses. Using a 100 TW-class Nd:glass chirped-pulse amplification laser facility, we report on the performance of a two-grating mosaic to compress high-energy pulses to 2.5 J, 450 fs (5.5 TW) in air with a beam size of 50 mm and energy transmission of 63%. Stability of the grating mosaic alignment was realized by use of an accurate nanopositioning optomechanical system. The output Gaussian spectrum was preserved from grating-gap spectral clipping and was free of modulation.
RESUMEN
We report on direct observation of temporal contrast degradation of short pulses amplified by optical parametric chirped-pulse amplification. We show that, despite injection seeding, quantum-noise-induced fast modulations (< 50 ps) of the temporal profile of the pump pulse are imprinted on the spectrum of the amplified chirped pulse and give rise to a large picosecond pedestal in the time domain.
RESUMEN
A new high-contrast, high-gain optical parametric chirped-pulse amplifier (OPCPA) architecture is demonstrated in periodically poled KTiOPO4 (PPKTP). This architecture overcomes parametric fluorescence contrast limitations of the OPCPA in periodically poled materials. The scheme is based on two passes of a single relay-imaged pump pulse and a free-propagating signal pulse through a 1.5 mm x 5 mm x 7.5 mm PPKTP crystal. The output energy of 1.2 mJ is generated at a center wavelength of 1053 nm by 24 mJ of pump energy. A prepulse contrast level of > 3 x 10(7) was measured with > 10(6) saturated gain in the amplifier. Amplified pulses were compressed to 200 fs. This simple and versatile concept requires only a modest pump energy from a commercial pump laser and represents a possible high-contrast front end for high-energy Nd:glass-based petawatt-class lasers.
RESUMEN
Modulation of voltage-gated L-type Ca2+ channels by phosphoinositide 3-kinase (PI3K) regulates Ca2+ entry and plays a crucial role in vascular excitation-contraction coupling. Angiotensin II (Ang II) activates Ca2+ entry by stimulating L-type Ca2+ channels through Gbeta-sensitive PI3K in portal vein myocytes. Moreover, PI3K and Ca2+ entry activation have been reported to be necessary for receptor tyrosine kinase-coupled and G protein-coupled receptor-induced DNA synthesis in vascular cells. We have previously shown that tyrosine kinase-regulated class Ia and G protein-regulated class Ib PI3Ks are able to modulate vascular L-type Ca2+ channels. PI3Ks display 2 enzymatic activities: a lipid-kinase activity leading to the formation of phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3 or PIP3] and a serine-kinase activity. Here we show that exogenous PIP3 applied into the cell through the patch pipette is able to reproduce the Ca2+ channel-stimulating effect of Ang II and PI3Ks. Moreover, the Ang II-induced PI3K-mediated stimulation of Ca2+ channel and the resulting increase in cytosolic Ca2+ concentration are blocked by the anti-PIP3 antibody. Mutants of PI3K transfected into vascular myocytes also revealed the essential role of the lipid-kinase activity of PI3K in Ang II-induced Ca2+ responses. These results suggest that PIP3 is necessary and sufficient to activate a Ca2+ influx in vascular myocytes stimulated by Ang II.