The business case for a healthy office; a holistic overview of relations between office workspace design and mental health.

The role of the physical workspace in employee mental health is often overlooked. As a (mentally) healthy workforce is vital for an organisation's success, it is important to optimise office workspace conditions. Previous studies on the effects of the physical workspace on mental health tended to focus on the effects of a specific element of the physical workspace on one or only a few mental health indicators. This study takes a more holistic approach by addressing the relationship of physical workspace characteristics with ten broad indicators of work-related mental health. Results of a systematic review of empirical evidence show that many aspects of (day)light, office layout/design, and temperature and thermal comfort have been proven to be related to many mental health indicators. Less tacit workspace characteristics (e.g., noise, use of colours) have been explored too, but so far have only been related to a few mental health indicators.Practitioner summary: The absence of holistic insights regarding the empirical proof of the effects of workspace design on employee mental health prevents a clear business case for workplace investments. This paper presents a content analysis of existing studies and shows how seven elements of workspace design relate to 10 mental health indicators.

Zif268/Egr1 gain of function facilitates hippocampal synaptic plasticity and long-term spatial recognition memory.

It is well established that Zif268/Egr1, a member of the Egr family of transcription factors, is critical for the consolidation of several forms of memory; however, it is as yet uncertain whether increasing expression of Zif268 in neurons can facilitate memory formation. Here, we used an inducible transgenic mouse model to specifically induce Zif268 overexpression in forebrain neurons and examined the effect on recognition memory and hippocampal synaptic transmission and plasticity. We found that Zif268 overexpression during the establishment of memory for objects did not change the ability to form a long-term memory of objects, but enhanced the capacity to form a long-term memory of the spatial location of objects. This enhancement was paralleled by increased long-term potentiation in the dentate gyrus of the hippocampus and by increased activity-dependent expression of Zif268 and selected Zif268 target genes. These results provide novel evidence that transcriptional mechanisms engaging Zif268 contribute to determining the strength of newly encoded memories.