Hepatic protein tyrosine phosphatase Shp2 disruption mitigates the adverse effects of ethanol in the liver by modulating oxidative stress and ERK signaling.

AIMS: Chronic excessive alcohol intake is a significant cause of alcohol-associated liver disease (ALD), a leading contributor to liver-related morbidity and mortality. The Src homology phosphatase 2 (Shp2; encoded by Ptpn11) is a widely expressed protein tyrosine phosphatase that modulates hepatic functions, but its role in ALD is mostly uncharted. MAIN METHODS: Herein, we explore the effects of liver-specific Shp2 genetic disruption using the established chronic-plus-binge mouse model of ALD. KEY FINDINGS: We report that the hepatic Shp2 disruption had beneficial effects and partially ameliorated ethanol-induced injury, inflammation, and steatosis in the liver. Consistently, Shp2 deficiency was associated with decreased ethanol-evoked activation of extracellular signal-regulated kinase (ERK) and oxidative stress in the liver. Moreover, primary hepatocytes with Shp2 deficiency exhibited similar outcomes to those observed upon Shp2 disruption in vivo, including diminished ethanol-induced ERK activation, inflammation, and oxidative stress. Furthermore, pharmacological inhibition of ERK in primary hepatocytes mimicked the effects of Shp2 deficiency and attenuated oxidative stress caused by ethanol. SIGNIFICANCE: Collectively, these findings highlight Shp2 as a modulator of hepatic oxidative stress upon ethanol challenge and suggest the evaluation of this phosphatase as a potential therapeutic target for ALD.

Hunting-Based Food Donation Programs: Program Characteristics Across the US.

OBJECTIVE: Hunting-based food donation (HBFD) programs are unique food assistance programs because they provide under-resourced food bank participants with a quality protein source. This study aimed to summarize the characteristics of US HBFD programs and discuss the potential barriers and considerations to use or access these programs. METHODS: Data were collected via a web search for HBFD programs within all 50 states and the District of Columbia. RESULTS: Most states were found to have an active program (n = 36), whereas 14 states and the District of Columbia do not have programs. Game donation amounts vary greatly between states, and funding for these programs typically comes from a government agency. CONCLUSIONS AND IMPLICATIONS: Hunting-based food donation can positively impact the food security and nutritional status of vulnerable populations. Nutrition professionals can aid in promoting awareness of these programs and provide nutrition education around wild game nutrition, safety, and food preparation.