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Bioorg Med Chem Lett
; 12(23): 3421-4, 2002 Dec 02.
Artículo
en Inglés
| MEDLINE
| ID: mdl-12419375
RESUMEN
Optimized substituent patterns in 4-aryl-pyridine glucagon receptor antagonists were merged to produce highly potent derivatives containing both a 3-[(1R)-hydroxyethyl] and a 2'-hydroxy group. Due to restricted rotation of the phenyl-pyridine bond, these analogues exist as four isomers. A diastereoselective methylcopper reaction was developed to facilitate the synthesis, and single isomers were isolated with activities in the range IC(50)=10-25 nM.