RESUMEN
BACKGROUND: This study aims to verify the condition of recipients of solid organs from donors with central nervous system (CNS) tumors and determine the risk of disease transmission due to transplantation. METHODS: Twenty-eight brain-dead organ donors with CNS tumors and 91 recipients who received solid organs from January 1, 2005, to December 31, 2014 in Korea were investigated using the Korean Network of Organ Sharing data. RESULTS: Of the 36 recipients of organs from the 11 donors whose pathological results were not verified, 4 developed the following tumors: renal cell carcinoma, carcinoma in situ of the cervix uteri, B-cell lymphoma, and colon cancer. Among 51 recipients from 17 donors with CNS tumor, no recipient had the same tumor as the donors. Six were classified as high-risk donors according to the World Health Organization classification, and 14 recipients from these donors did not develop tumor after transplantation. The remaining 11 donors were classified as low-risk donors according to the World Health Organization classification but as high-risk donors according to the Malignancy Subcommittee of the Disease Transmission Advisory Committee of the Organ Procurement and Transplantation Network/United Network for Organ Sharing. Of the 37 recipients, 3 had recurring hepatocellular carcinoma with lung and bone metastases, thyroid cancer, and Kaposi's sarcoma after transplantation. CONCLUSIONS: The risk of disease transmission due to organ transplantation from donors with CNS tumors was very low. Thus, organ donation from such donors should be promoted actively to expand the donor range.
Asunto(s)
Neoplasias del Sistema Nervioso Central/epidemiología , Selección de Donante/normas , Trasplante de Órganos/normas , Donantes de Tejidos/estadística & datos numéricos , Receptores de Trasplantes/estadística & datos numéricos , Neoplasias del Sistema Nervioso Central/etiología , Selección de Donante/métodos , Humanos , Trasplante de Órganos/estadística & datos numéricos , Sistema de Registros/estadística & datos numéricos , República de Corea/epidemiologíaRESUMEN
Concise total synthesis of obovatol (1) was achieved from the commercially available eugenol (5) via linear 4 steps in 40% overall yield. The key features of the synthesis involve the chemoselective orthobromination of phenol in the presence of isolated double bond and the efficient Cu-catalyzed Ullmann coupling of two aromatic moieties for the diaryl ether skeleton.
Asunto(s)
Antiinfecciosos/síntesis química , Compuestos de Bifenilo/síntesis química , Bromo/química , Cobre/química , Fenoles/química , Éteres Fenílicos/síntesis química , Alquenos/química , Catálisis , Éteres , Ligandos , Espectrofotometría Infrarroja , Espectroscopía Infrarroja por Transformada de FourierRESUMEN
Stereocontrolled methods for the direct and divergent synthesis of the silylenol ethers possessing amino group from beta-amino aldehydes have been achieved. These enol ethers with the defined olefin geometry could be key building blocks for the synthesis of the medicinally impor tant compounds.
Asunto(s)
Aldehídos/química , Éteres/síntesis química , Alquenos/química , Alquilación , Compuestos de Bencilo/síntesis química , Indicadores y Reactivos , Espectroscopía de Resonancia Magnética , Metilación , Silanos/síntesis química , EstereoisomerismoRESUMEN
A series of novel diaryl ethers possessing various functional groups were synthesized and evaluated for antiproliferative activity in human myeloid leukemia HL-60 cells. Among the compounds examined, compounds 10, 17, 20, 24, and 33 showed moderate to potent antiproliferative activity. These derivatives were further examined in terms of their abilities to inhibit tubulin polymerization; however, all of the tested compounds were relatively ineffective. The reference compound E7010 with an IC(50) of 0.34 microM exhibited potent antiproliferative activity and significantly inhibited tubulin polymerization in a dose-dependent manner.