miRNA-Based Early Healing Mechanism of Extraction Sockets: miR-190a-5p, a Potential Enhancer of Bone Healing.

Objective: Tooth extraction causes a wound with hard and soft tissue defects in the alveolar ridge. Few studies have reported the function of microRNAs (miRNAs) in the healing of extraction sockets. This study used bioinformatics analysis to reveal the possible relevance and role of miRNAs during the early stages following tooth extraction. Materials and Methods: Socket tissues from beagle dogs (Canis familiaris; two males and two females) were collected 1 and 12 hours after extraction of premolars on both sides of the mandible. miRNA expression was profiled through miRNA sequencing, and hub miRNAs showing characteristic expression patterns were selected and subjected to target enrichment analysis. Alkaline phosphatase (ALP) activity analysis and reverse transcription-quantitative polymerase chain reaction (RT-qPCR) were performed to verify the effect of hub miRNA on osteoblast differentiation and bone regeneration in vivo. Results: Five miRNAs were identified to have consistently high expression levels, with cfa-miR-451 showing the highest expression. Additionally, 20 hub miRNAs were selected as candidates expected to play an important role in the healing process. Pathways, such as the MAPK, axon guidance, TGF-ß, and Wnt signaling, were significantly enriched. Among hub miRNAs, miR-190a-5p increased ALP activity and mRNA expression of osteogenic markers and increased new bone formation in vivo. Conclusions: Our findings suggest that miRNAs may be involved in the earliest stages of socket healing after tooth extraction and can play an important role in moderating the entire socket healing mechanism in the extraction socket.

Ultrahigh Sensitive Au-Doped Silicon Nanomembrane Based Wearable Sensor Arrays for Continuous Skin Temperature Monitoring with High Precision.

Monitoring the body temperature with high accuracy provides a fast, facile, yet powerful route about the human body in a wide range of health information standards. Here, the first ever ultrasensitive and stretchable gold-doped silicon nanomembrane (Au-doped SiNM) epidermal temperature sensor array is introduced. The ultrasensitivity is achieved by shifting freeze-out region to intrinsic region in carrier density and modulation of fermi energy level of p-type SiNM through the development of a novel gold-doping strategy. The Au-doped SiNM is readily transferred onto an ultrathin polymer layer with a well-designed serpentine mesh structure, capable of being utilized as an epidermal temperature sensor array. Measurements in vivo and in vitro show temperature coefficient of resistance as high as -37270.72 ppm °C-1 , 22 times higher than existing metal-based temperature sensors with similar structures, and one of the highest thermal sensitivity among the inorganic material based temperature sensors. Applications in the continuous monitoring of body temperature and respiration rate during exercising are demonstrated with a successful capture of information. This work lays a foundation for monitoring body temperature, potentially useful for precision diagnosis (e.g., continuous monitoring body temperature in coronavirus disease 2019 cases) and management of disease relevance to body temperature in healthcare.

Practical Demonstration of Deep-Ultraviolet Detection with Wearable and Self-Powered Halide Perovskite-Based Photodetector.

Flexible and self-powered photodetectors (PDs) have become one of the most popular topics, attracting researchers in the field of optoelectronic applications. In this study, for the first time, we demonstrate partial discharge detection in a practical environment with a prepared flexible device. Poly(vinylidene fluoride) (PVDF) is utilized as a highly transparent material in the UVC region, to create a flexible substrate with the antihumidity property. A detector that uses a mixed-halide perovskite (FAPbI3)1-x(MAPbBr3)x as the photoactive material is constructed in a vertical structure on the as-prepared hydrophobic PVDF substrate. The fabricated device exhibits good performance with a fast response speed (trise = 82 ms, tfall = 64 ms) and a high detectivity of 7.21 × 1010 Jones at zero bias under 254 nm UV illumination, along with superior mechanical flexibility at various bending angles. Additionally, the air-exposure stability and reproducibility of the as-prepared device exhibit almost the original performance after 6 weeks of storage. For practical applications, we demonstrate a facile and sensitive detection for UVC leakage from a germicidal lamp and simulated a partial discharge system using our PD without energy consumption. These results indicate that this new approach may be useful and convenient for the detection of the partial discharge as well as for several practical applications.

Characteristics of Perovskite Solar Cells (PSCs) with Various Metal Electrode Deposited Using Thermal Evaporators.

Organic material-based solar cell devices such as perovskite solar cells (PSCs) have attracted attention as renewable energy resources with low production cost, lightweight, wearable device applications, and large-area processability. To enhance device performance, many research groups have attempted to develop new materials and structures. Metal electrode materials play an important role in solar energy conversion in PSCs, owing to the ohmic contact and contact resistance between metal negative electrodes and photoactive layers. Until recently, conventional metal sources such as Ag, Au, or Cu have been used as electrodes. In this study, PSCs were employed in various metal negative electrodes using a thermal evaporator. The authors investigated the effect of metal negative electrodes on PSCs.