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1.
Sensors (Basel) ; 22(19)2022 Sep 23.
Artículo en Inglés | MEDLINE | ID: mdl-36236330

RESUMEN

A digital twin is a digital representation of a physical entity that is updated in real-time by transfer of data between physical and digital (virtual) entities. In this manuscript we aim to introduce a digital twin framework for robotic drilling. Initially, a generic reference model is proposed to highlight elements of the digital twin relevant to robotic drilling. Then, a precise reference digital twin architecture model is developed, based on available standards and technologies. Finally, real-time visualisation of drilling process parameters is demonstrated as an initial step towards implementing a digital twin of a robotic drilling process.


Asunto(s)
Procedimientos Quirúrgicos Robotizados , Robótica , Cirugía Asistida por Computador
2.
J Immunother ; 41(1): 32-34, 2018 01.
Artículo en Inglés | MEDLINE | ID: mdl-29111982

RESUMEN

Recent advancements in immunotherapy have brought promising drugs to fight cancers; a subset of immunotherapy medications are known as checkpoint inhibitors. Their mechanism of action relies on upregulating antitumor response by reversing T-cell suppression; as a consequence the effect can also result in a spectrum of immune related complications. Reported complications to date include: skin, gastrointestinal mucosa, hypophysis, liver, endocrine system, nervous system, kidney, musculoskeletal system and the hematologic system. The management of immune related complications typically includes the use of steroids and other strategies of immunosuppression. The current recommendations are not organ-specific and little is known about the response and outcomes related to the hematologic system. Hereby we report four cases evaluated at the hematology service at the University of Texas MD Anderson Cancer Center for cytopenias after check point inhibitor therapies. All cases were responsive to conventional interventions for immune-mediated cytopenias.


Asunto(s)
Anemia Hemolítica/diagnóstico , Anticuerpos Monoclonales Humanizados/uso terapéutico , Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos/diagnóstico , Inmunoterapia/métodos , Ipilimumab/uso terapéutico , Melanoma/terapia , Neutropenia/diagnóstico , Prednisona/uso terapéutico , Neoplasias de la Próstata/terapia , Carcinoma Pulmonar de Células Pequeñas/terapia , Anemia Hemolítica/tratamiento farmacológico , Antígeno CTLA-4/inmunología , Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos/tratamiento farmacológico , Femenino , Humanos , Masculino , Melanoma/inmunología , Persona de Mediana Edad , Metástasis de la Neoplasia , Neutropenia/tratamiento farmacológico , Receptor de Muerte Celular Programada 1/inmunología , Neoplasias de la Próstata/inmunología , Carcinoma Pulmonar de Células Pequeñas/inmunología
3.
ACS Biomater Sci Eng ; 2(12): 2153-2161, 2016 Dec 12.
Artículo en Inglés | MEDLINE | ID: mdl-33465891

RESUMEN

Cell-specific uptake of drug delivery systems (DDSs) are crucial to achieve optimal efficacy of many drugs. Widely employed strategies to facilitate targeted intracellular drug delivery involves attachment of targeting ligands (peptides or antibodies) to DDSs. Target receptors mutations can limit the effectiveness of this approach. Herein, we demonstrate, through in vitro inhibitory and drug delivery studies, that graphene nanoribbons (GNRs), water dispersed with the amphiphilic polymer called PEG-DSPE ((1, 2-distearoyl-sn-glycero-3-phosphoethanolamine-N [amino (polyethylene glycol)]) (induce membrane depolarization-mediated epidermal growth factor receptor (EGFR) activation. This phenomenon is ligand-independent and EGFR activation occurs via influx of Ca2+ ions from the extracellular space. We further provide evidence, through in vivo studies, that this mechanism could be exploited to facilitate efficacious drug delivery into tumors that overexpress EGFR. The results suggest that transient membrane depolarization-facilitated cell receptor activation can be employed as an alternate strategy for enhanced intracellular drug delivery.

4.
Chem Commun (Camb) ; (5): 620-1, 2003 Mar 07.
Artículo en Inglés | MEDLINE | ID: mdl-12669854

RESUMEN

With a highly encumbered manganese porphyrin as catalyst, significant improvements in regioselectivity towards less substituted C-C double bond in diene epoxidation were attained by simply adding organic bases as axial ligand.

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