Trends in ESBLs and PABLs among enteric Salmonella isolates from children in Gwangju, Korea: 2014-2018.

OBJECTIVES: Non-typhoid Salmonella infection is a major agent of food-borne outbreaks as well as individual cases worldwide. However, few studies on drug-resistant Salmonella strains, especially those recovered from young children, are available. Therefore, we determined the prevalence and characteristics of cephalosporin-resistant Salmonella isolates in the south-west region of Korea over a five-year period. METHODS: Non-duplicate Salmonella clinical isolates were recovered from diarrhoeagenic patient specimens at 12 hospitals in Gwangju, Korea between January 2014 and December 2018. Antimicrobial susceptibility testing and molecular features of cephalosporin-resistant isolates were determined. RESULTS: A total of 652 Salmonella isolates were collected and 48 cefotaxime-resistant Salmonella isolates (7.4%), that belonged to nine Salmonella serovars, were identified. These were S. Enteritidis, S. Typhimurium, S. I 4,[5],12:i:-, S. Virchow, S. Agona, S. Bareilly, S. Infantis, S. Newport, and S. Schleissheim. The prevalence rate increased from 5.3% in 2014 to 10.3% in 2018. S. Virchow (44.4%) showed significantly high resistant rate compared to the other serovars. PGFE genotyping revealed high genetic homogeneities among each Salmonella serovars, suggesting clonal dissemination of cephalosporin-resistant strains. CONCLUSIONS: Progressive increases in carriage rates and the possibility of community outbreaks by cephalosporin-resistant Salmonella in young children may pose tangible public health threats.

Comparison of knee biomechanical characteristics during exercise between pinnacle and step trainers.

BACKGROUND: A novel stair-climber called a pinnacle trainer (PT) provides both sagittal and frontal plane exercise, making it different from a step trainer (ST), which provides only sagittal plane exercise. Exercise with different trajectories may produce different biomechanical responses. There are currently no guidelines for choosing between a PT and a ST for different training or rehabilitation purposes. RESEARCH QUESTIONS: Are there differences in the electromyographic patterns of lower extremity musculature and biomechanical responses of the knee joint during exercise between using a PT and a ST? METHODS: This study utilizes a prospective observational study design. Eighteen healthy males participated in the study. A six-axis force and torque transducer embedded in the machine pedal synchronized with a three-dimensional motion capture system were utilized to measure kinematic and kinetic data of the right knee during the stepping movement. The activities of six lower extremity muscles of the same limb were captured with surface electromyography during exercise on the two trainer types. RESULTS: The co-activation index of the vastus lateralis (VL) and the biceps femoris (BF) recorded during ST exercise was significantly greater than that for the PT exercise. Moreover, exercise using the ST produced a significantly greater knee downward force compared to that for the PT. Exercise with the PT produced a significantly greater internal knee varus moment compared to that for the ST. SIGNIFICANCE: The ST provided greater co-activation of the BF and VL and a greater knee joint downward force, which may decrease the antero-posterior displacement of the tibia relative to the femur. Exercise with the PT produced a significant internal knee varus moment and a more balanced muscular activation on the vastus medialis and VL compared to that for the ST, which may decrease the maltracking of the patella.

Effects of body weight support and pedal stance width on joint loading during pinnacle trainer exercise.

BACKGROUND: A pinnacle trainer is a stair climber that has a biplane exercise trajectory and an adjustable pedal stance width (PSW). A pinnacle trainer integrated with a body weight support (BWS) system can help overweight individuals or individuals with poor balance exercise safely by reducing excessive or improper joint loads, preventing training-related injuries. However, few studies have investigated the biomechanical features of the lower extremities during pinnacle trainer exercise with and without partial BWS for various PSWs. RESEARCH QUESTION: We aimed to investigate the effects of partial BWS and PSW on the joint loading of the lower extremities during stepping on a pinnacle trainer. METHODS: Seventeen healthy adults exercised on the pinnacle trainer with or without BWS using various PSWs. The joint resultant forces and joint moments of the lower extremities were calculated according to the kinematic and kinetic data measured via a motion capture system and force transducers on the pedals, respectively. RESULTS: The joint resultant forces and joint moments of the lower extremities significantly decreased with increasing percentage of BWS. The internal knee adduction moment and internal hip abduction moment significantly increased with increasing PSW. For every kilogram of BWS, the joint loading of the lower extremities decreased by approximately 1% of the joint resultant forces of body weight during exercise with the pinnacle trainer. SIGNIFICANCE: Exercise on the pinnacle trainer with partial BWS significantly reduced joint loading. Exercise with a wider pedal stance may be helpful for knee osteoarthritis rehabilitation as it produces greater internal hip abduction and internal knee adduction moments.

Effect of metacarpophalangeal joint position on A1 pulley and flexor digitorum tendons in trigger digit.

BACKGROUND: The aim of this study was to evaluate and compare the cross-sectional area (CSA) of flexor digitorum tendons and the thickness of first annular (A1) pulleys between contralateral normal digits and trigger digits (TDs) at positions of finger flexion and extension using a noninvasive ultrasound system. METHODS: Seventeen affected fingers of 17 patients (6 men and 11 women) with TDs in one hand, and 17 contralateral normal digits without trigger finger symptoms were examined. The sonographic appearances of flexor digitorum tendons and A1 pulleys were observed at two positions of metacarpophalangeal (MCP) joint flexion: 0° and 60°. RESULTS: The findings of this study indicate that CSA of flexor digitorum tendons and A1 pulley thickness were significantly larger in both positions of 0° and 60° flexion of MCP joint compared with contralateral normal digits (p < 0.01). In TDs, there was a significantly thicker A1 pulley at 60° flexion of MCP joint than that at 0° flexion (p < 0.01), but no significant change on CSA of flexor tendons. CONCLUSION: Our results suggested that TDs lead to the thicker A1 pulley and larger CSA of the flexor digitorum tendons. The mismatch in volume change between CSA of flexor digitorum tendons and A1 pulley thickness during MCP flexion may lead to the trigger phenomenon.

Characteristics of Sonography in a Rat Achilles Tendinopathy Model: Possible Non-invasive Predictors of Biomechanics.

The purpose of this study was to investigate the dynamic changes of histopathology, biomechanical properties, echo intensity, and ultrasound features in a collagenase-induced tendinopathy model of rat Achilles tendons, and to examine the associations among biomechanical properties, echo intensity, and ultrasound features. Forty-two rats received an ultrasound-guided collagenase injection on their left Achilles tendons, and needle puncture on the right ones as the control. At four, eight, and twelve weeks post-injury, the tendons were examined via measurements of their biomechanical properties, histopathological and ultrasonographic characteristics. The injured tendons showed significantly higher histopathological scores, lower Young's modulus, and higher ultrasound feature scores than the those of control ones throughout the study period. Up to week 12, all injured tendons showed defective healing. The neovascularization score had a significant negative linear association with the failure stress and Young's modulus. Maximum normalized echo intensity had a significant positive linear association with maximum strain. Therefore, neovascularization and maximum normalized echo intensity are associated with mechanically altered tendinopathic tendons. Non-invasive ultrasound methodology, including echo intensity and ultrasound feature scores, may provide useful information about biomechanical properties of tendinopathic tendons.

Incidence and Characteristics of Scarlet Fever, South Korea, 2008-2015.

The incidence rate for scarlet fever in South Korea is rising. During 2008-2015, we collected group A Streptococcus isolates and performed emm and exotoxin genotyping and disk-diffusion antimicrobial tests. Scarlet fever in South Korea was most closely associated with emm types emm4, emm28, emm1, and emm3. In 2015, tetracycline resistance started increasing.

The Potential Risk Factors Relevant to Lateral Epicondylitis by Wrist Coupling Posture.

The use of awkward wrist postures and unskilled techniques might induce lateral epicondylitis. This study thus investigated the effects of wrist deviation combined with extension and movement velocity on the dynamic performances of the wrist muscles during the coupling posture via a custom-made bi-planar isokinetic dynamometer. Thirty subjects were recruited to perform the isokinetic testing. We measured the muscle strengths and activities for the wrist extensors and flexors during concentric and eccentric contractions at three movement velocities, 30°s(-1), 90°s(-1), and 180°s(-1), combined with three wrist postures, neutral position (NP), radial deviation (RD), and ulnar deviation (UD). The root mean square (RMS) of the electromyographic signal in the extensor digitorum communis (EDC), normalized peak torque of extensors, and ratio of normalized peak torque between wrist extensors and flexors, were all greater in the NP than RD and UD in both contractions. The ratio of RMS between EDC and flexor digitorum superficialis (FDS) had a significantly greater value in RD than UD during the concentric contraction. The EDC showed significantly higher activity at the fast velocity in both contractions. Nevertheless, a significantly higher RMS of the electromyographic signal between EDC and FDS and the ratio of strength between wrist extensors and flexors were found at slow velocity in both contractions. The wrist deviation combined with extension and movement velocity of the wrist joint should thus be considered as influential factors which might alter the dynamic performances, and may result in further injury of the elbow joint.

Three-dimensional characteristics of neck movements in subjects with mechanical neck disorder.

STUDY DESIGN: Controlled laboratory study. OBJECTIVES: To examine characteristics of neck movement at three-dimensional planes for subjects with mechanical neck disorder (MND) and measure cervical range of motion, coupling motion, and calculation of the upper cervical rotation ratio. BACKGROUND: MND is characterized by symptoms of neck pain, headache, dizziness and limited range of motion (ROM). However, the characteristics of neck movements across the three-dimensional planes in MND patients remain unknown. METHODS: Forty participants were recruited, which consisted of twenty-seven subjects with MND and 13 healthy subjects. A three-dimensional electromagnetic motion capture device with custom data analysis software was used to measure the neutral position of the neck and the range of motion of upper and lower cervical spine. RESULTS: The results indicate that subjects with MND had significantly decreased ROM in right rotation (p< 0.05) and extension (p< 0.05) movements compared to the healthy group. Increased coupling motion (p< 0.05) in the rotation plane during cervical flexion was also found in the MND group compared to control group. For rotations in neutral or in flexion positions, rotation to the right showed smaller range of motion compared to rotation to the left. CONCLUSION: In this study, MND was associated with altered cervical movement patterns with increases in coupling motion. The findings may help to differentiate MND from whiplash-associated disorder. Increasing upper cervical spine rotation mobility may be crucial for treating deficiencies in neck rotation in patients with MND.