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1.
J Phys Ther Sci ; 28(7): 2009-13, 2016 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-27512253

RESUMEN

[Purpose] This study compared the effects of pilates and an exercise program on the craniovertebral angle, cervical range of motion, pain, and muscle fatigue in subjects with a forward head posture (FHP). [Subjects and Methods] A total of 28 sedentary females (age 20 to 39 years) with FHP were randomly assigned to pilates (n=14) and combined (n=14) exercise groups. The study was a randomized, controlled, double-blind study with the two groups performing exercise 50 min/day, 3 days/week, with an intensity of 11-15 rating of perceived exertion (RPE) for ten weeks. The main outcome measures were craniovertebral angle, cervical range of motion (ROM), pain levels assessed by visual analog scale (VAS), and neck disability index (NDI). Surface electromyography was also used to measure muscle fatigue. [Results] There were significant increases in craniovertebral angle and cervical ROM in the pilates group, but none in the control group. The only significant differences in muscle activity were recorded in the sternocleidomastoid muscle in the pilates group. Both exercise programs had positive effects on pain measures, as VAS and NDI were significantly decreased. [Conclusion] The results suggest that pilates could be recommended as an appropriate exercise for treatment of FHP in sedentary individuals.

2.
Pain Physician ; 17(6): E747-54, 2014.
Artículo en Inglés | MEDLINE | ID: mdl-25415789

RESUMEN

BACKGROUND: Ice hockey is a competitive sport and ice hockey injuries can be influenced by many physical and psychological factors. Young ice hockey players are especially vulnerable to injury due to their relative lack of experience and rapid physical growth during their juvenile years. Up to now there has been no survey of the physical, psychological, and environmental etiological factors based on the Korean high school ice hockey players population. PURPOSE: The purpose of our study was to evaluate, through a comprehensive survey, the incidence of ice hockey injuries according to age and the relationship between etiological factors and injuries in high school students. STUDY DESIGN: A cross-sectional study. METHODS: One hundred nineteen ice hockey players in Korean high schools were recruited for this study. The study was conducted by a self-administered questionnaire survey. The researcher explained the purpose of the survey and how to fill it out. Individual questionnaires were distributed to participants. Chi-squared tests were used to evaluate the relationship between the independent and dependent values. There was a significant difference between a player's age and injury incidence (P = .018). The injury level of each position showed a significant tendency (P = .055). Age was highly correlated with the number of total injuries (P = .019). RESULTS: The average demographic characteristics of those surveyed were age (16.7 years), play line (2.2), height (174.8 cm), weight (69.6 kg), and body mass index (23.4). The shoulder was the most frequent injury area and the knee was the most common cause of hospital visits. There was a higher injury incidence in older groups; however, there was no correlation with body mass index, position, and play line. The causative factors were divided into physical factors, psychological factors, and environmental factors. Generally, 3 factors were not closely regarded as etiologic factors of ice hockey injury. However, deficiency of fitness in the physical factor, aggressiveness in the psychological factor, and injury by other players in the environmental factor showed a high etiological correlation for ice hockey injury. CONCLUSION: The multiple aspects of this etiological factor analysis showed modest results. However, based on our results, in order to reduce the long-term implications of youth ice hockey injuries and associated public health costs, comprehensive efforts, including psychological and environmental factor modification, should be put in place.


Asunto(s)
Traumatismos en Atletas/etiología , Hockey/estadística & datos numéricos , Instituciones Académicas/estadística & datos numéricos , Estudiantes/estadística & datos numéricos , Adolescente , Traumatismos en Atletas/epidemiología , Estudios Transversales , Humanos , Masculino , República de Corea/epidemiología
3.
Bioorg Med Chem Lett ; 19(21): 6161-5, 2009 Nov 01.
Artículo en Inglés | MEDLINE | ID: mdl-19783142

RESUMEN

Benzylidene-2,4-thiazolidinedione derivatives with substitutions on the phenyl ring at the ortho or para positions of the thiazolidinedione (TZD) group were synthesized as PTP1B inhibitors with IC50 values in a low micromolar range. Compound 3e, the lowest, bore an IC50 of 5.0 microM. In vivo efficacy of 3e as an antiobesity and hypoglycemic agent was evaluated in a mouse model system. Significant improvement of glucose tolerance was observed. This compound also significantly suppressed weight gain and significantly improved blood parameters such as TG, total cholesterol and NEFA. Compound 3e was also found to activate peroxisome proliferator-activated receptors (PPARs) indicating multiple mechanisms of action.


Asunto(s)
Fármacos Antiobesidad/química , Inhibidores Enzimáticos/química , Hipoglucemiantes/química , Éteres Fenílicos/química , Proteína Tirosina Fosfatasa no Receptora Tipo 1/antagonistas & inhibidores , Tiazolidinedionas/química , Animales , Fármacos Antiobesidad/síntesis química , Fármacos Antiobesidad/farmacología , Sitios de Unión , Glucemia/metabolismo , Dominio Catalítico , Simulación por Computador , Inhibidores Enzimáticos/síntesis química , Inhibidores Enzimáticos/farmacología , Hipoglucemiantes/síntesis química , Hipoglucemiantes/farmacología , Ratones , PPAR gamma/antagonistas & inhibidores , PPAR gamma/metabolismo , Éteres Fenílicos/síntesis química , Éteres Fenílicos/farmacología , Proteína Tirosina Fosfatasa no Receptora Tipo 1/metabolismo , Tiazolidinedionas/síntesis química , Tiazolidinedionas/farmacología
4.
J Histochem Cytochem ; 51(1): 129-32, 2003 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-12502763

RESUMEN

An immunohistochemical method using biotinyl tyramine was recently introduced to amplify weak staining signals. Despite its high sensitivity, however, tyramine-based immunostaining has been limited by its increased background staining. In this study, to develop an improved protocol of biotinyl tyramine-based immunohistochemistry minimizing the background staining, we determined which staining steps lead to the nonspecific reaction and the most appropriate blocking agents for background-provoking steps. Trypton casein peptone and distilled water with Tween-20 were shown to be most effective as a blocking agent and a rinsing solution, respectively. In conclusion, we developed an optimized protocol for biotinyl tyramine-based immunohistochemistry with minimal background staining.


Asunto(s)
Biotina/análogos & derivados , Inmunohistoquímica/métodos , Coloración y Etiquetado/métodos , Tiramina/análogos & derivados , Humanos , Ganglios Linfáticos/química
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