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Objective To study the development trend and research status of the subject in the field of the development trend of ultrasound-guided nerve block by bibliometric analysis.Methods By using PubMed and SCI-E databases,we searched the literatures about ultrasound-guided nerve block published over these years,and used the GoPubMed platform and BIBLIOMETRC.COM to document the bibliometric data from two sources separately.Results Through a series of comparative analysis,we discussed the research status and development trend of ultrasound-guided nerve block,obtained the core research force in this field,and summarized the periodicals and hot-spots of this article.Conclusions Ultrasound-guided nerve block has gradually entered the slow stage of research in the world,but the related research in our country is still in the rising stage.At present,the leading force in this field is still in the United States and Canada.We should pay more attention to track the trends and improve our research capabilities.
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OBJECTIVE(S): To investigate the expression of human papilloma virus (HPV) L1 capsid protein, and human telomerase RNA component (hTERC) in cervical cancer and the role of detection of both genes in screening of cervical cancer. MATERIALS AND METHODS: A total of 309 patients were recruited and cervical exfoliated cells were collected. Immunocytochemistry was employed to detect HPV L1 capsid protein, and fluorescent in situ hybridization (FISH) was performed to detect the hTERC. RESULTS: The expression of HPV L1 capsid protein reduced with the increase of the histological grade of cervical cells and was negatively related to the grade of cervical lesions. However, the expression of hTERC increased with the increase of the histological grade and positively associated with the grade of cervical lesions. The proportion of patients with L1(-)/hTERC(+) was higher in patients with histological grade of CIN2 or higher than that in those with histological grade of CIN1. The L1(+)/hTERC(-) and L1(-)/hTERC(-) were negatively related to the grade of cervical lesions. L1(-)/hTERC(+) was positively associated with the grade of cervical lesions. The L1/hTERC ratio increased. The negative predictive value of both HPV L1 and hTERC was higher than that of HPV L1 or hTERC, but there was no marked difference in the screening efficacy of cervical cancer among HPV L1, hTERC and HPV L1+hTERC. CONCLUSION: HPV L1 capsid protein and hTERC gene may serve as markers for the early diagnosis and prediction of cervical lesions. The increase in L1/hTERC ratio reflects the progression of cervical lesions to a certain extent.
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We investigated the present situation of teaching materials of pathophysiology abroad with medical informatics.Some excellent pathophysiology textbooks are identified from various aspects and levels.
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Purpose:To study analgesia effect and adverse reaction of diclofenac sodium extended release capsule for cancer pain in senile patients. Methods:20 senile patients with light or moderate cancer pain were selected.The analgesia effect and adverse reaction were observed after diclofenac sodium extended release capsule 100 mg qn po.Results:The treatment of cancer pain with diclofenac sodium extended release capsule in senile patients had obvious analgesia effect without obvious adverse reaction. Conclusions:Diclofenac sodium extended release capsule 100 mg qn po is a safe,effective and simple way to relieve cancer pain in senile patients with light or moderate cancer pain.
