1.
Nat Struct Mol Biol
; 27(2): 221, 2020 Feb.
Artículo
en Inglés
| MEDLINE
| ID: mdl-31932763
RESUMEN
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
2.
Nat Struct Mol Biol
; 26(11): 994-998, 2019 11.
Artículo
en Inglés
| MEDLINE
| ID: mdl-31636415
RESUMEN
We present structures of mouse TRPV3 in temperature-dependent open, closed and intermediate states that suggest two-step activation of TRPV3 by heat. During the strongly temperature-dependent first step, sensitization, the channel pore remains closed while S6 helices undergo α-to-π transitions. During the weakly temperature-dependent second step, channel opening, tight association of the S1-S4 and pore domains is stabilized by changes in the carboxy-terminal and linker domains.