Manejo con control de temperatura en los cuidados posparada cardiaca: documento de expertos / Management of temperature control in post-cardiac arrest care: an expert report

Actualmente, el control estricto de temperatura mediante hipotermia inducida (entre 32 y 36 oC) se considera un tratamiento de primera línea en el manejo de pacientes con parada cardiaca recuperada que ingresan en Unidades de Cuidados Intensivos. Su objetivo es disminuir el daño neurológico secundario a anoxia cerebral. Aunque existen múltiples evidencias sobre sus beneficios, el empleo de esta técnica en nuestro país es pobre y todavía existen temas controvertidos como temperatura óptima, velocidad de instauración, duración y proceso de calentamiento. El objetivo de este trabajo es desarrollar la evidencia científica actual y las recomendaciones de las principales guías internacionales. El enfoque de este documento se centra también en aplicación práctica del control estricto de la temperatura en la parada cardiaca recuperada en nuestras Unidades de Cuidados Intensivos Generales o Cardiológicas, principalmente en los métodos de aplicación, protocolos, manejo de las complicaciones y elaboración del pronóstico neurológico. (AU)

Targeted temperature management (TTM) through induced hypothermia (between 32-36 oC) is currently regarded as a first-line treatment during the management of post-cardiac arrest patients admitted to the Intensive Care Unit (ICU). The aim of TTM is to afford neuroprotection and reduce secondary neurological damage caused by anoxia. Despite the large body of evidence on its benefits, the TTM is still little used in Spain. There are controversial issues referred to its implementation, such as the optimal target body temperature, timing, duration and the rewarming process. The present study reviews the best available scientific evidence and the current recommendations contained in the international guidelines. In addition, the study focuses on the practical implementation of TTM in post-cardiac arrest patients in general and cardiological ICUs, with a discussion of the implementation strategies, protocols, management of complications and assessment of the neurological prognosis. (AU)

Management of temperature control in post-cardiac arrest care: an expert report. / Manejo con control de temperatura en los cuidados posparada cardiaca: documento de expertos.

Targeted temperature management (TTM) through induced hypothermia (between 32-36 oC) is currently regarded as a first-line treatment during the management of post-cardiac arrest patients admitted to the Intensive Care Unit (ICU). The aim of TTM is to afford neuroprotection and reduce secondary neurological damage caused by anoxia. Despite the large body of evidence on its benefits, the TTM is still little used in Spain. There are controversial issues referred to its implementation, such as the optimal target body temperature, timing, duration and the rewarming process. The present study reviews the best available scientific evidence and the current recommendations contained in the international guidelines. In addition, the study focuses on the practical implementation of TTM in post-cardiac arrest patients in general and cardiological ICUs, with a discussion of the implementation strategies, protocols, management of complications and assessment of the neurological prognosis.

Edema pulmonar neurogénico y shock cardiogénico asociado a brote de esclerosis múltiple / Neurogenic pulmonary edema and cardiogenic shock secondary to acute multiple sclerosis exacerbation

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Características epidemiológicas de las paradas cardiorrespiratorias extrahospitalarias registradas porel sistema de emergencias 061 (SAMU) de la Comunidad Autónoma de las Islas Baleares (2009-2012) / Epidemiological characteristics of out-of-hospital cardiorespiratory arrest recorded by the 061 emergencies system (SAMU) in the Balearic Islands (Spain), 2009-2012

OBJETIVO: Describir las características epidemiológicas de las paradas cardiorrespiratorias extra hospitalarias (PCEH) y determinar los factores asociados a la recuperación de la circulación espontánea (RCE). Diseño: Estudio observacional de cohorte de PCEH registradas de forma continua en la base de datos del SAMU 061 (2009-2012). Ámbito: Islas de Mallorca, Ibiza, Menorca y Formentera. PACIENTES: PCEH ≥ de 18 años. Variables principales de interés: sexo, edad, sospecha etiológica, lugar, testigo, si fue presenciada, soporte vital básico (SVB), ritmo desfibrilable, intervalos de tiempos, desfibrilador semiautomático (DEA), duración de parada cardiaca (PC) y RCE. Las variables independientes fueron definidas según el estilo Utstein y la variable dependiente fue la RCE. RESULTADOS: Se atendió a 1.170 PC (28/100.000 habitantes/año). Se incluyeron 1.130 casos. La edad media fue de 61,4 años. El 72,3% fueron de etiología cardiaca y el 84,7% fueron presenciadas. En 840 (74,3%) se practicó SVB y en 400 (47,6%) se realizó previamente a la llegada del SAMU (45 por familiares). En 330 paradas (29,2%) se utilizó el DEA (96 indicó desfibrilación). Los intervalos alerta-SVB y alerta-SVA fueron de 8,4 y 15,8 min respectivamente. Se monitorizó ritmo desfibrilable en 257 PC (22,7%). La RCE se consiguió en 261 casos (23,1%). Los factores asociados a RCE fueron la edad, el ritmo desfibrilable, SVB previo a la llegada del SAMU y duración de PC ≤ 30 min. CONCLUSIONES: La incidencia de PCEH es baja. El SVB realizado por la familia fue poco frecuente. La edad, ritmo desfibrilable y SVB previo al SAMU se asocian a RCE

OBJECTIVE: To describe the epidemiology of out-of-hospital cardiorespiratory arrest (OHCA) and identify factors associated with recovery of spontaneous circulation (ROSC). Observational study of OHCA registered on a continuous basis in the Emergency Medical Services (EMS) database during 2009-2012. SETTING: The islands of Mallorca, Ibiza, Menorca and Formentera (Balearic Islands, Spain). PATIENTS: OHCA in patients ≥ 18 years of age. The main variables were: Patient sex, age, probable cause, place of arrest, bystander, witnessed, basic life support (BLS), shockable rhythm, intervention time, semi-automatic defibrillator (AED), duration of cardiopulmonary arrest (CA), and ROSC. Independent variables were defined according to the Utstein protocol, and the dependent variable was defined as ROSC. RESULTS: The EMS treated 1170 OHCAs (28/100,000 persons-year). We included 1130 CA. The mean age was 61.4 years (73.4% males). Most CA (72.3%) were of cardiac etiology, and 84.7% were witnessed. A total of 840 (74.3%) received BLS and 400 (47.6%) did so before arrival of the EMS (45 by bystander relatives). AED was available in 330 cases CA (29.2%) (96 with shockable rhythm). The interval between emergency call and BLS and between emergency call and advanced life support was 8.4 and 15.8min, respectively. Shockable rhythm was monitored in 257 CAs (22.7%). ROSC occurred in 261 (23.1%). Factors associated with ROSC were age, shockable rhythm, BLS before EMS arrival, and CA duration less than 30min.ConclusionThe incidence rate of the OHCA is low. The proportion of patients receiving BLS from relatives was low. Age, shockable rhythm and BSL before EMS arrival were associated with ROSC

[Epidemiological characteristics of out-of-hospital cardiorespiratory arrest recorded by the 061 emergencies system (SAMU) in the Balearic Islands (Spain), 2009-2012]. / Características epidemiológicas de las paradas cardiorrespiratorias extrahospitalarias registradas por el sistema de emergencias 061 (SAMU) de la Comunidad Autónoma de las Islas Baleares (2009-2012).

OBJECTIVE: To describe the epidemiology of out-of-hospital cardiorespiratory arrest (OHCA) and identify factors associated with recovery of spontaneous circulation (ROSC). DESIGN: Observational study of OHCA registered on a continuous basis in the Emergency Medical Services (EMS) database during 2009-2012. SETTING: The islands of Mallorca, Ibiza, Menorca and Formentera (Balearic Islands, Spain). PATIENTS: OHCA in patients ≥ 18 years of age. The main variables were: Patient sex, age, probable cause, place of arrest, bystander, witnessed, basic life support (BLS), shockable rhythm, intervention time, semi-automatic defibrillator (AED), duration of cardiopulmonary arrest (CA), and ROSC. Independent variables were defined according to the Utstein protocol, and the dependent variable was defined as ROSC. RESULTS: The EMS treated 1170 OHCAs (28/100,000 persons-year). We included 1130 CA. The mean age was 61.4 years (73.4% males). Most CA (72.3%) were of cardiac etiology, and 84.7% were witnessed. A total of 840 (74.3%) received BLS and 400 (47.6%) did so before arrival of the EMS (45 by bystander relatives). AED was available in 330 cases CA (29.2%) (96 with shockable rhythm). The interval between emergency call and BLS and between emergency call and advanced life support was 8.4 and 15.8min, respectively. Shockable rhythm was monitored in 257 CAs (22.7%). ROSC occurred in 261 (23.1%). Factors associated with ROSC were age, shockable rhythm, BLS before EMS arrival, and CA duration less than 30min. CONCLUSION: The incidence rate of the OHCA is low. The proportion of patients receiving BLS from relatives was low. Age, shockable rhythm and BSL before EMS arrival were associated with ROSC.

Manejo del síndrome posparada cardíaca / Managing the post-cardiac arrest syndrome

Desde el advenimiento de la resucitación cardiopulmonar (RCP), hace más de 40 años, se ha conseguido que cada vez una mayor proporción de pacientes con parada cardiorrespiratoria logren la recuperación de la circulación espontánea (RCE). Sin embargo, la mayoría de estos pacientes fallecen en los primeros días tras su ingreso en las unidades de cuidados intensivos (UCI), y esta situación no ha mejorado en estos años. La mortalidad de estos pacientes se asocia en gran medida a daño cerebral. Posiblemente, el reconocimiento de que la RCP no se acaba con la RCE, sino con el retorno de la función cerebral normal y la estabilización total del paciente, nos ayudará a mejorar el tratamiento terapéutico de estos pacientes en las UCI. En este sentido, parece más apropiado el término «resucitación cardiocerebral», como proponen algunos autores. Recientemente, el Internacional Liaison Committee on Resuscitation (ILCOR) ha publicado un documento de consenso sobre el «síndrome posparada cardíaca» y diversos autores han propuesto que los cuidados posparada se integren como un quinto eslabón de la cadena de supervivencia, tras la alerta precoz, la RCP precoz por testigos, la desfibrilación precoz y el soporte vital avanzado precoz. El manejo terapéutico de los pacientes que recuperan la circulación espontánea tras las maniobras de RCP basada en medidas de soporte vital y una serie de actuaciones improvisadas basadas en el «juicio clínico» puede que no sea la mejor forma de tratar a los pacientes con «síndrome posparada cardíaca». Estudios recientes indican que el tratamiento de estos pacientes mediante protocolos guiados por objetivos -incluyendo las medidas terapéuticas que han demostrado su eficacia, como la hipotermia terapéutica inducida leve y la revascularización precoz, cuando esté indicada- puede mejorar notablemente el pronóstico de éstos. Dado que en el momento actual no existe un protocolo basado en la evidencia universalmente aceptado, el Comité Directivo del Plan Nacional de RCP de la Sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias (SEMICYUC), tras una revisión exhaustiva de la literatura científica sobre el tema, seguida de una discusión en línea entre todos los miembros del comité y una reunión de consenso, ha elaborado el presente documento con la intención de que pueda servir como base para el desarrollo de protocolos locales en las diferentes UCI de nuestro país, teniendo en cuenta sus medios y sus características propias (AU)

Since the advent of cardiopulmonary resuscitation more than 40 years ago, we have achieved a return to spontaneous circulation in a growing proportion of patients with cardiac arrest. Nevertheless, most of these patients die in the first few days after admission to the intensive care unit (ICU), and this situation has not improved over the years. Mortality in these patients is mainly associated to brain damage. Perhaps recognizing that cardiopulmonary resuscitation does not end with the return of spontaneous circulation but rather with the return of normal brain function and total stabilization of the patient would help improve the therapeutic management of these patients in the ICU. In this sense, the term cardiocerebral resuscitation proposed by some authors might be more appropriate. The International Liaison Committee on Resuscitation recently published a consensus document on the «Post-Cardiac Arrest Syndrome» and diverse authors have proposed that post-arrest care be integrated as the fifth link in the survival chain, after early warning, early cardiopulmonary resuscitation by witnesses, early defibrillation, and early advanced life support. The therapeutic management of patients that recover spontaneous circulation after cardiopulmonary resuscitation maneuvers based on life support measures and a series of improvised actions based on «clinical judgment» might not be the best way to treat patients with post-cardiac arrest syndrome. Recent studies indicate that using goal-guided protocols to manage these patients including therapeutic measures of proven efficacy, such as inducing mild therapeutic hypothermia and early revascularization, when indicated, can improve the prognosis considerably in these patients. Given that there is no current protocol based on universally accepted evidence, the Steering Committee of the National Cardiopulmonary Resuscitation Plan of the Spanish Society of Intensive Medicine and Cardiac Units has elaborated this document after a thorough review of the literature and an online discussion involving all the members of the committee and a consensus meeting with the aim of providing a platform for the development of local protocols in different ICSs in our country to fit their own means and characteristics (AU)

[Managing the post-cardiac arrest syndrome. Directing Committee of the National Cardiopulmonary Resuscitation Plan (PNRCP) of the Spanish Society for Intensive Medicine, Critical Care and Coronary Units (SEMICYUC)]. / Manejo del síndrome posparada cardíaca. Comité Directivo del Plan Nacional de Resuscitación Cardiopulmonary de la SEMICYUC (Sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias).

Since the advent of cardiopulmonary resuscitation more than 40 years ago, we have achieved a return to spontaneous circulation in a growing proportion of patients with cardiac arrest. Nevertheless, most of these patients die in the first few days after admission to the intensive care unit (ICU), and this situation has not improved over the years. Mortality in these patients is mainly associated to brain damage. Perhaps recognizing that cardiopulmonary resuscitation does not end with the return of spontaneous circulation but rather with the return of normal brain function and total stabilization of the patient would help improve the therapeutic management of these patients in the ICU. In this sense, the term cardiocerebral resuscitation proposed by some authors might be more appropriate. The International Liaison Committee on Resuscitation recently published a consensus document on the "Post-Cardiac Arrest Syndrome" and diverse authors have proposed that post-arrest care be integrated as the fifth link in the survival chain, after early warning, early cardiopulmonary resuscitation by witnesses, early defibrillation, and early advanced life support. The therapeutic management of patients that recover spontaneous circulation after cardiopulmonary resuscitation maneuvers based on life support measures and a series of improvised actions based on "clinical judgment" might not be the best way to treat patients with post-cardiac arrest syndrome. Recent studies indicate that using goal-guided protocols to manage these patients including therapeutic measures of proven efficacy, such as inducing mild therapeutic hypothermia and early revascularization, when indicated, can improve the prognosis considerably in these patients. Given that there is no current protocol based on universally accepted evidence, the Steering Committee of the National Cardiopulmonary Resuscitation Plan of the Spanish Society of Intensive Medicine and Cardiac Units has elaborated this document after a thorough review of the literature and an online discussion involving all the members of the committee and a consensus meeting with the aim of providing a platform for the development of local protocols in different ICSs in our country to fit their own means and characteristics.

Absence of the superior vena cava: difficulties for pacemaker implantation.

Endocardial pacemaker electrode implantation can be difficult in patients with anomalous superior vena cava (SVC). Venography and CAT scan showed that the patient lacked SVC venous drainage and that systemic veins drained into the inferior vena cava through the azygos vein. A temporary stimulation electrode was placed by puncture of the femoral vein, permanent stimulation by venotomy of the epigastric vein, with the electrode inserted through the external iliac vein.

[Loss of intravenous nitroglycerin administered with polyvinyl chloride infusion systems]. / Pérdidas de nitroglicerina intravenosa al administrarla mediante sistemas de infusión de cloruro de polivinilo.

To evaluate the consequences of the interaction between intravenous nitroglycerin (NTG) and infusion systems made of polyvinyl chloride (PVC), 20 dilutions of NTG were prepared in glass bottles with an initial concentration of 200 micrograms/ml, which were infused through 20 infusion systems at a rate of 20 ml/hour during 12 hours. NTG concentrations collected at the terminal part of the infusion systems were evaluated after 5 minutes, 6 hours and 12 hours. The results showed a substantial loss of NTG through PVC systems. The loss was 20% after 5 minutes and up to 32% after 12 hours. These results, obtained with a preparation similar to that used in clinical practice, may be helpful to estimate the real dose of the infused drug.