[The laboratory evidences of chronic disease impact on the development of anemia under female reproductive system pathology].

The study sample included 170 patients with gynecological diseases, 5 patients with persistent anemia due to systematic blood disorder, 14 healthy patients. The decrease of hemoglobin level lower than 110 g/l is established in 25.7% gynecologic patients and most frequently in those with hysteromyoma. The study revealed that anemia developed due to the female reproductive system disorders and independently of clinically marked loss of blood is an. The biologic characteristic of anemia is the decrease of erythrocytes production under certain diseases against the background of inadequate production of endogenic erythropoietin. The effectiveness of treatment of iron-deficiency anemia is less under decrease of amount of erythrokaryocytes in bone marrow.

[New capabilities for diagnosis of iron-deficiency anemia by computer morphometry of reticulocytes].

With the advent of new cytological techniques, such as computer morphometry, the problems in the study of the structure of reticulocytes that characterize insignificant changes in the parameters of erythroid population functioning in the bone marrow in response to altered hemoglobin synthesis in patients with iron-deficiency anemia (IDA) become topical. The changes in peripheral blood reticulocytes in IDA determine those in red blood cells and may be a reliable differential diagnostic tool to identify IDA.

[A new approach to studying anemia in patients with gynecological diseases and gynecological neoplasms].

The authors have used a coefficient that characterizes the functional activity of red blood cells. Evidence is provided for the significance of the coefficient, by comparing the groups of gynecological and gynecological cancer patients.

[Characteristics of anemia in patients with oncogynecological pathology].

The aim of the study was to elucidate complex changes in Hgb, erythrocyte count, ESR, and MCH in patients with oncogynecological problems depending on the affected organ and stage of the disease. A total of 340 women were examined in the oncogynecological department of No 40 city hospital, Moscow, from 2005 to 2008. The group included 132 patients with gynecological, 177 with oncogynecological and 31 with oncologycal diseases. A common coefficient was derived to characterize functional activity of erythrocytes The notion of intoxication effect coefficient (IC) is introduced and substantiated. Erythrocyte IC is shown to be useful for the comparison of groups with gynecological and oncogynecological problems. It decreases in patients with a tumorigenic process depending on its phase.

[Detection rates of various serotypes of human papilloma virus in atypical glandular hyperplasia and adenocarcinoma of the endometrium and their immunomorphological features in virus-positive cases].

Various virus serotypes were found in 35.3% of cases and their detection rate frequency reducing with age. They were detectable in 35.3 -52.9% of cases of atypical glandular hyperplasia, highly and moderately differentiated adenocarcinoma of the endometrium and only in 17.6% of cases of poorly differentiated adenocarcinomas. Serotypes 58 and 51 were nearly twice more frequently, but serotypes 18 and 52 were not observed. Immunomorphologically virus-positive observations were characterized by pronounced infiltration with T-helper and T-suppressor/killer cells. The endometrium and tumors showed an increased significant proliferative activity (Ki-67 expression) and reduced expression of receptors to progesterone and, to a lesser degree, to estrogen in 47-83% of virus-positive cases. Expression of growth factors did not greatly differ.

[Morpho- and angiogenetic characteristics of uterine leiomyoma].

Ordinary and cellular leiomyomas of 147 patients (age 23 - 65 years) were studied histologically and immunomorphologically. Five females with rapidly growing tumors were operated after therapy with gonadotropines blockers. Variants with weak and pronounced proliferative activity of neoplastic myocytes and various activity of neoangiogenesis were distinguished. The latter may be either phases of development or different tumour types. Use of gonadotropine blockers inhibits myocyte proliferation and activates formation of stroma.

[The viral and bacterial nature of dysplasia and of cervical carcinoma]. / Virusno-bakterial'naia priroda displazii i raka sheiki matki.

The role of the infection component in etiopathogenesis of dysphasia and cervical carcinoma as well as optimization of their diagnosis and treatment schemes are discussed in the paper. On the basis of published data and authors' independent examinations, a tense relationship between the presence of dysphasia and cervical carcinoma, on the one hand, and sexually-transmitted genital infection and/or bacterial vaginosis present in the medial history, on the other hand, was verified. An intensity of vagina-microflora dysbacteriosis in genital clamidiosis and in dysphasia of cervical carcinoma as observed in women as well as an evaluation of immunoglobulins' levels in vaginal secretions can be a prognosticating criteria for a conducted treatment. A high efficiency and feasibility were shown of adding the recombinant alpha2-interferon to the combined treatment of genital clamidiosis and to preventing it from being chronic as well as to correcting the dysplastic impairments an to preventing the malignant neoplasms in the neck of uterus.