[The Karachi health resort: synthesis of science and practice].

This article is devoted to the history of one of the oldest Siberian health resorts known as "The Karachi Lake". It describes the stages of its development, the scientific component of the system of spa-and-resort therapy and medico-social rehabilitation of the patients. The detailed analysis of the mechanisms underlying the beneficial action of the natural therapeutic factors, cooperation with the leading research institutions, and the formation of the modern scientific and technical basis have strengthened the position of the resort on the market of the medical, health-promoting, and recreational services due to the development of the new activities in this field.

[The chronobiological peculiarities of the hepatobiliary system function in chronic cholecystitis with dysfunction of the gallbladder].

Study of biological cycles in chronic cholecystitis with dysfunction of gallbladder has a great practical importance. The results of chronoanalysis testify a dominance of 24-hours cycle in structure of cycles of functional activity of organs of hepatobiliary system. The comparative analysis of trust intervals reveals the intensification of internal connections, expressed intensification of synchronization of cycles of functional activity of system and a breach of synchronism of central regulation and self-regulation, testifying overstrain of proper adaptive possibilities and unconcordance in system of regulation. This manifestations of desynchronization provokes development and progress of dysfunction of gallbladder and dysbalance of vegetative nervous system, that make worse the present disturbances.

[The application of UHF therapy for the prevention of complications of specific antiblastoma therapy in the patients presenting with III-IV stage lung cancer].

One of the complications of specific antiblastoma therapy in the patients presenting with malignant neoplasms is the suppressed functional activity of blood neutrophil granulocytes. The results of clinical and experimental investigations suggest the enhanced enzymatic activity of neutrophils and lymphocytes under effect of ultrahigh-frequency electromagnetic radiation (UHF EMR). Our study has demonstrated that UHF EMR with a frequency selected on an individual basis in the range from 59 to 63 GHz exerts the protective action on the function and metabolism of blood neutrophils exposed to the damaging action of gamma-radiation in the patients presenting with lung cancer. Moreover, it allows the severity of local and systemic complications of specific antiblastoma chemo- and radiotherapy in these patients to be reduced.

[The development of medical technologies for the spa and resort rehabilitation of patients presenting with pathology of the biliary system taking into consideration circumannual biorhythms].

This study included 188 patients presenting with pathology of the biliary system, such as dyskinesia of bile ducts, chronic non-calculous cholecystitis (CCC), and dysfunction of the bile system. The objective of the work was to develop complexes of intensive non-medicamental rehabilitative treatment for the correction of the adaptive potential of the organism in the springtime (March-May). It was shown that the efficacy of therapy during this period can be improved by modulation of the complex structure. New treatment modalities were proposed taking into consideration specific changes of clinical characteristics in different phases of the circumannual cycle and curative effects of various therapeutic factors that increase the adaptive potential of the organism. These complexes allowed both the efficiency and the tolerability of the treatment to be improved. It is concluded that the use of corrected complexes of intensive therapy in springtime (March-May) permits to reduce the duration of therapy by 5-6 days from the usual 21-24 days using the traditional approach.

[Circumannular features of non-specific resistance in patients with osteoarthrosis in mid-lattitudes].

Modified cosinor-analysis was used to calculate biorhythmologic characteristics (period, amplitude, phase, mesor) of the circumannual rhythm of neuroendocrine regulation parameters, the state of bioradical hemostasis, and protein components of non-specific resistance in patients with osteoarthrosis living in moderate climates. Near-annual rhythms of these parameters are described. The chronological analysis indicates that strenuouos activity of the regulatory systems responsible for adaptive reactions of the organism falls within the periods from March to May and from August to October. Variability of the above parameters is shown to be related to the efficacy of osteoarthrosis therapy in different phases of the near-annual rhythm.

Changes in liver structure in experimental CCl4-induced hepatitis during different phases of circumannual cycle.

Changes in liver structure in experimental CCl4-induced hepatitis depend on the phase of the circumannual cycle. Pronounced disorders in the liver with a model of toxic hepatitis were observed in winter and fall and minor changes were recorded in summer. In spring, the liver was characterized by higher adaptation and compensatory potential, its structural status spontaneously returned to normal on day 4 after the last injection of CCl4.

[A chronobiological approach to the treatment of obesity in children based at a sanatorium and spa facility].

The objective of the study was to evaluate results of non-medicamental treatment of 167 children with obesity taking into account dynamics of annual rhythms of their clinical, hormonal, metabolic, and psychological characteristics. The period from August till November was shown to be especially favourable in terms of body weight loss, improvement of hormonal, metabolic, and psychic status. Analysis of these changes permitted to correct the proposed mode of combined therapy of obesity during the period from December till July.

[Seasonal variations of nucleic acid content in an experiment on non-pharmacological correction of the hepatic function].

This experiment was preformed on an animal model of CCl4 hepatitis using 320 Wistar rats. The animals underwent combined effect of saprogel and a magnetic field during different seasons. It was shown that non-medicamentous treatment of experimental CCl4 hepatitis had the most pronounced beneficial effect on the synthetic liver function in the winter time. An appreciable suppression of the hepatic function was documented in the spring.

[Prospects for the development of health resort and recreational resources in southern Siberia].

Long-term monitoring natural health remedial factors of southern Siberia provided materials for the comparative evaluation of bioclimatic characteristics of sanatorium-and-spa facilities in major health and recreational areas of this region. The most promising localities for climatic balneotherapy, tourist and recreational activities have been identified at the territory of the Altai-Sayan mountain system. The database of sanatorium-and-spa facilities, health and recreational sites located in this region is presented. The rational exploitation of mountainous landscapes including strict constraints on nature use activities is recommended as a basis for the further development of recreational industry.

[A method for predicting the efficiency of rehabilitative treatment based on decision tree analysis].

The necessity of the choice of means and methods to facilitate optimal correction of individual reserves of the organism accounts for the importance of the search for the most efficient preventive, therapeutic, and rehabilitative modalities. One way to address this problem is to simulate prognosis of the outcomes of rehabilitative treatment. It is proposed to use a two-step method to achieve this goal. Step 1 consists of construction of the decision tree to perform categorization of all objects of interest (patients) into the previously established classes; it provides a basis for step 2 or classification proper of new observations. The original software program ensures high accuracy of prognosis of the efficiency of two scenarios of combined sanatorium and spa treatment used in the present study. A special case of application of the decision tree analysis in clinical practice is considered. It is concluded that this approach can be recommended for the use in all specialized medical and health care facilities for the management of a variety of pathological conditions.

[Effect of extreme conditions on seasonal patterns of endocrine and metabolic processes].

The study was designed to clarify seasonal patterns of endocrine and metabolic processes and their changes under extreme conditions in Special Police Force servicemen. Hormonal status, lipid spectra, activity of lipid peroxidation and nonspecific protection systems were assessed during transition seasons. It was shown that the stay in a local armed conflict zone had marked effect on the structure of adaptive reactions. Hormonal dysregulation and impaired efficiency of protective systems were most pronounced during the autumn/winter season. Disturbed endocrine regulation in winter/spring resulted in undesirable changes of lipid metabolism and increased load on the protective function mediated through bioactive radicals.

[The rationale for chronooptimization of rehabilitative treatment under mid-latitude conditions].

Rhythmic patterns in the functioning of different systems of the body should be taken into consideration when developing new therapeutic modalities intended for the improvement of efficiency of health care measures. The study of chronobiological features of the work of organ systems in patients with different diseases residing in mid-latitude regions provided a rationale for the differential approach to the prescription of medicinal preparations of natural origin in selected periods of the annual cycle.

[Efficiency of short courses of physiotherapy with the use of energy metabolism regulators in patients with dorsopathy].

The assessment of procedure tolerance, their efficiency at shortening of courses of dorsopathies physiotherapy to 12-14 days made possible to detect presence of unfavorable reactions to treatment in 32% of cases. Regulator of energy metabolism, included in the therapy, assists to good tolerance to shortened courses of dorsopathy rehabilitation (frequency of presence and expression degree of reaction to treatment reduced to 15%), stabilization of energy system in patients' organism, absence of hyper activation and stress of adaptive mechanisms, maintenance of compensatory abilities reserves.

[Biorhythms to improve efficiency of the treatment of patients with chronic opisthorchosis].

To make the treatment of bile-excreting dysfunctions more effective still remains an actual problem of clinical medicine. Use of chronobiological approach in the treatment is possible to resolve that problem. For any system including bile-excreting one, its own biorhythms are typical. Lesion of these systems causes changes of the biorhythms. Use of parameters of biorhythms of bile-excreting system activity expects an individual or group chronobiological approach in the treatment of patients with chronic opisthorchosis. The combined treatment of opisthorchosis with the use of such approach makes possible to improve efficiency of the treatment and to maintain received effect up to 6 months. It indicates increase the terms of remission and prevents development of early recidivation.

[Morphological criteria of chronic opisthorchiasis treatment].

Morphological examinations of the liver in chronic opisthorchiasis have both diagnostic and prognostic importance. Significant lowering of the number of cells of the portal tract inflammatory infiltrate per area unit (1 mmI), decreased number of neutrophilic and eosinophilic leukocytes, elevated count of monocytes are not only morphological markers of successful dehelminthization but they also reflect objective improvement of the liver state this being an absolute criterion of effective therapy.

[Nondrug treatment for opisthorchiasis].

In vitro experimental studies of the antiopisthorchiasis properties of currently available non-drug treatment are ofgreat practical value. The studies demonstrated that the herbal drug ecorsol and the background resonance radiation of the Opisthorchis spectrum exerted an anti-helminthic effect that was evaluated by the marital death and amounted to 83.6 to 96.4%. The experimental studies provided evidence that the background radiation, by using the electromagnetic spectrum of Opisthorchis, had a sufficient helminthocidal effect on mature Opisthorchis felineus in the in vitro experiment, which allows these means to be recommended for the non-drug treatment of chronic opisthorchiasis.

[A new approach to medical rehabilitation of combatants].

The study of endocrine-metabolic and immune status of combatants with different forms of chronic diseases but free of combat wounds gave grounds for working up a new approach to correction of poststress disorders. The above correction includes staged rehabilitation with a corrective basic complex at the first stage.

[Geomagnetic effects on hepatic function in different phases of the annual cycle].

Investigations on 496 Wistar rats have revealed that in winter geomagnetic deviations (GMD) have no effect on hepatic function of the intact animals. GMD in spring and summer provoked functional impairment of the liver while in autumn intact and CCl4 hepatitis rats exhibited GMD-related normalization of liver function. Thus, efficacy of physiotherapeutic correction of the liver depends on the phase of the annual cycle and geomagnetic situation.