RESUMEN
Plasma prednisolone levels have been measured hourly in children receiving a single dose of oral prednisone. Peak prednisolone levels occurred one to two hours after ingestion; half-life studies gave a mean value of 132 minutes in most children. Some children had marked variability in absorption and metabolism of prednisone. Somatomedin activity and cell-mediated immunity were inhibited by plasma prednisolone values which were achieved by single doses of prednisone of 0.5 mg/kg or higher. Monitoring prednisolone levels may be of value in identifying those children who accumulate excessively high levels on moderate dosage regimens.
Asunto(s)
Prednisolona/sangre , Administración Oral , Adolescente , Hiperfunción de las Glándulas Suprarrenales/tratamiento farmacológico , Asma/tratamiento farmacológico , Disponibilidad Biológica , Niño , Preescolar , Enfermedad de Crohn/tratamiento farmacológico , Dermatomiositis/tratamiento farmacológico , Femenino , Semivida , Humanos , Inmunidad Celular/efectos de los fármacos , Lupus Eritematoso Sistémico/tratamiento farmacológico , Masculino , Síndrome Nefrótico/tratamiento farmacológico , Prednisolona/administración & dosificación , Prednisolona/metabolismo , Prednisolona/uso terapéutico , Somatomedinas/sangreRESUMEN
Oliguric renal failure, bilateral renal enlargement, and hyperuricemia were noted in three term infants. The findings on intravenous pyelography and radionuclide renography were consistent with intratubular obstruction to urinary outflow in two of the infants. The onset of diuresis appeared to follow intravenous pyelography in these infants. Urinary urate crystalluria was prominent in each infant in the first few days after the onset of diuresis, during which normal serum urate concentrations and normal renal function were established.
Asunto(s)
Enfermedades del Recién Nacido/metabolismo , Enfermedades Renales/metabolismo , Ácido Úrico/metabolismo , Diuresis , Femenino , Humanos , Recién Nacido , Enfermedades Renales/sangre , Enfermedades Renales/orina , Embarazo , Ácido Úrico/sangre , Ácido Úrico/orinaAsunto(s)
Reflujo Vesicoureteral/terapia , Niño , Preescolar , Humanos , Reflujo Vesicoureteral/cirugíaRESUMEN
A family is described in which gross vesicoureteral reflux and renal scarring are present in the father and three sons, none with a history of urinary tract infection. Vesicoureteral reflux alone is present in an infant daughter. Father-to-son transmission of vesicoureteral reflux has not been previously reported. Autosomal dominant inheritance of the trait is suggested. The renal scarring noted in these patients may reflect generalized maldevelopment of affected renal units. The increasing recognition of vesicoureteral reflux as a familial trait suggests the need for evaluation of families in which vesicoureteral reflux is found in more than one member.