Manipulation of Skyrmion Motion Dynamics for Logical Device Application Mediated by Inhomogeneous Magnetic Anisotropy.

Magnetic skyrmions are promising potential information carriers for future spintronic devices owing to their nanoscale size, non-volatility and high mobility. In this work, we demonstrate the controlled manipulation of skyrmion motion and its implementation in a new concept of racetrack logical device by introducing an inhomogeneous perpendicular magnetic anisotropy (PMA) via micromagnetic simulation. Here, the inhomogeneous PMA can be introduced by a capping nano-island that serves as a tunable potential barriers/well which can effectively modulate the size and shape of isolated skyrmion. Using the inhomogeneous PMA in skyrmion-based racetrack enables the manipulation of skyrmion motion behaviors, for instance, blocking, trapping or allowing passing the injected skyrmion. In addition, the skyrmion trapping operation can be further exploited in developing special designed racetrack devices with logic AND and NOT, wherein a set of logic AND operations can be realized via skyrmion-skyrmion repulsion between two skyrmions. These results indicate an effective method for tailoring the skyrmion structures and motion behaviors by using inhomogeneous PMA, which further provide a new pathway to all-electric skyrmion-based memory and logic devices.

Sirt1 activator SRT2104 protects against oxygen-glucose deprivation/reoxygenation-induced injury via regulating microglia polarization by modulating Sirt1/NF-κB pathway.

Cerebral ischemic/reperfusion injury is the most common neurological disorder and the second leading cause of death worldwide. Modulating microglia polarization from pro-inflammatory M1 phenotype to anti-inflammatory M2 state has been suggested as a potential therapeutic approach in the treatment of this injury. SRT2104, a novel activator of histone deacetylase Sirtuin-1 (Sirt1), has recently been shown to have anti-inflammation properties. However, the effect of SRT2104 on cerebral ischemic/reperfusion injury has not been elucidated. Here, we found that SRT2104 inhibited neuron and microglia death directly and indirectly through microglia condition medium from an oxygen glucose deprivation/reoxygenation (OGD/R) -induced cell injury models. Moreover, SRT2104 treatment modulated the microglia polarization shift from the M1 phenotype and skewed toward the M2 phenotype. Additionally, we found that SRT2104 could significant inhibit the activation of NF-κB and enhanced Sirt1 expression in microglia. Mechanism studies using the BV2 microglial cell line confirmed that knockdown Sirt1 significantly reduced the effect of SRT2104 on the activation of NF-κB pathway and microglial phenotype shift. Altogether, our result shows SRT2104 protect OGD/R-induced injury through shifting microglia phenotype, which may have potential in further studies as a novel neuroprotective agent for cerebral ischemic/reperfusion injury therapy.

Controllable entanglement preparations between atoms in spatially-separated cavities via quantum Zeno dynamics.

By using quantum Zeno dynamics, we propose a controllable approach to deterministically generate tripartite GHZ states for three atoms trapped in spatially separated cavities. The nearest-neighbored cavities are connected via optical fibers and the atoms trapped in two ends are tunably driven. The generation of the GHZ state can be implemented by only one step manipulation, and the EPR entanglement between the atoms in two ends can be further realized deterministically by Von Neumann measurement on the middle atom. Note that the duration of the quantum Zeno dynamics is controllable by switching on/off the applied external classical drivings and the desirable tripartite GHZ state will no longer evolve once it is generated. The robustness of the proposal is numerically demonstrated by considering various decoherence factors, including atomic spontaneous emissions, cavity decays and fiber photon leakages, etc. Our proposal can be directly generalized to generate multipartite entanglement by still driving the atoms in two ends.

B-cell lymphoma/leukemia-2 and benign prostatic hyperplasia / 中华男科学杂志

The B-cell lymphoma/leukemia-2 (Bcl-2) gene is an important member of the Bcl-2 family, a type of protein that plays an important role in the process of cell apoptosis. Bcl-2 does not change the rate of cell proliferation, but prolongs the life and increases the number of cells by counteracting a series of apoptosis. In the recent years, more and more evidence has shown a close correlation of the Bcl-2 gene with the development and progression of benign prostatic hyperplasia (BPH), a disease whose mechanism is not yet fully understood but is drawing more and more attention towards the role of cell apoptosis.

Longchang granule upregulates the expression of bax in the prostatic hyperplastic tissues of rats / 中华男科学杂志

<p><b>OBJECTIVE</b>To investigate the mechanism of Longchang Granule in the treatment of benign prostatic hyperplasia.</p><p><b>METHODS</b>Rat models of prostate hyperplasia were made by castration and testosterone propionate injection. After treated respectively with Longchang Granule and Longbishu by gastrogavage for 30 days, all the model rats were killed and their prostate glands harvested for the measurement of the wet weight and detection of the expression of bax in the prostatic hyperplastic tissues by RV 2-step method.</p><p><b>RESULTS</b>The wet weight of the prostate was (0.61 +/- 0.03) g in the blank control group, (0.95 +/- 0.04) g in the model group, (0.73 +/- 0.02) g in the Longbishu group, (0.80 +/- 0.05) g in the low-dose Longchang group, (0.78 +/- 0.07) g in the medium-dose Longchang group and (0.68 +/- 0.03) g in the high-dose Longchang group, with significant differences between the model and the intervention groups (P < 0.05). The prostate indexes in the above groups were 0.143 +/- 0.006, 0.226 +/- 0.008, 0.172 +/- 0.004, 0.199 +/- 0.012, 0.181 +/- 0.010 and 0.168 +/- 0.003, respectively, and the expressions of bax by mean optical density were 0.226 +/- 0.010, 0.184 +/- 0.005, 0.206 +/- 0.015, 0.199 +/- 0.001, 0.202 +/- 0.003 and 0.211 +/- 0.003, respectively, both with significant differences between the model and the intervention groups (P < 0.05).</p><p><b>CONCLUSION</b>Longchang Granule can effectively reduce the wet weight of the prostate and alleviate its pathological changes in BPH rats, the mechanism of which may be associated with its effect of upregulating the expression of bax and accelerating cell apoptosis in the prostate tissues.</p>

Effect of soluble granule of Shengjing on the apoptosis in spermatogenic cells of rats caused by varicocele / 中华男科学杂志

<p><b>OBJECTIVE</b>To investigate the apoptosis of spermatogenic cells of rats caused by experimental varicocele and effect of soluble granules of Shengjing on the apoptosis.</p><p><b>METHODS</b>Sixty Wistar male rats were divided into three group: control group, model group, and treatment group. Experimental varicocele was induced by partial ligation of the left renal vein in Wistar rat. Apoptosis cells in the testes were detected by in situ terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling(TUNEL) Technique.</p><p><b>RESULTS</b>The apoptosis index in model group was remarkably higher than that in control group (P < 0.001). There was significant difference between treatment and model groups in apoptosis index.</p><p><b>CONCLUSION</b>The apoptosis of spermatogenic cells by varicocele may play a important role in leading to subfertility. The soluble granules of Shengjing have negative effects on the apoptosis of spermatogenic cells. The medicine can not only protect spermic production but improve the ability of procreation of testes.</p>

Progress in studies of glutathione S-transferase P1 and prostate cancer / 中华男科学杂志

Prostate cancer ( PCa) is an important genitourinary malignancy with increasing morbidity and mortality. Glutathione S-transferase P1 ( GSTP1) , as a phrase- II enzyme, has an important role in the activation and detoxification of carcinogens. There is a close association between GSTP1 gene polymorphisms and the risk of Pca. GSTP1 CpG island hypermethylation can reliably distinguish Pca from benign prostatic hyperplasia( BPH) and promises to be an important molecular marker for the diagnosis of Pca. This paper summarizes the association of GSTP1 with the diagnosis and risk of Pca.

[Floral homeotic variants of in vitro seedlings in Sinningia speciosa Hiern].

Six types of floral homeotic variants of in vitro seedlings were observed in doubleflower sinningia. Type I, red and green mosaic petals exist in the outermost whorl of petal-whorls, 2.38%. Type II, the outermost whorl of petal-whorls exhibit green petals with thin yellow edge, 25.0%. Type III, green petals exist in the innermost side of normal red petal whorls, 1.78%. Type IV, multiple whorls of green petals exist in the inner side of normal sepals, no stamen and carpel, 1.67%. Type V, it exhibits duplicated whorls of sepals in the outermost, 7.14%. Type VI, it exists multiple whorls of green sepals, no petal, stamen and carpel, 0.12%. The total percentage of all types of floral homeotic variants is up to 38.1%. The distribution of nodal site of homeotic flowers were analyzed, and the results showed that the homeotic flower occurred mainly at the fourth and fifth nodes.