Spontaneous rupture­induced life­threatening mediastinal mixed germ cell tumor: A case report and therapeutic considerations.

Spontaneous rupture and hemorrhage of mediastinal germ cell tumors is a rare occurrence. In the current report, the case of a 20-year-old male patient who was admitted with chest tightness and dyspnea is presented. An urgent chest CT scan revealed a large tumor in the right anterior mediastinum, measuring ~12 cm in diameter, with associated intratumoral hemorrhage. An emergency thoracotomy was performed to excise the lesion, which revealed that the bleeding was caused by a ruptured tumor. Postoperative pathological findings revealed a mediastinal mixed germ cell tumor consisting of four pathological types: Embryonal carcinoma, seminoma, yolk sac tumor and immature teratoma. Postoperatively, the patient showed marked improvement in the symptoms of dyspnea. However, the follow-up outcome was poor, and the patient succumbed 2 months after surgery. To the best of our knowledge, there are no reports of rupture and hemorrhage involving >4 mixed germ cell tumors. In the present report, the experience of the treatment of the patient is summarized, and literature was reviewed to improve clinicians' awareness of the disease.

Ferroptosis in lung cancer: dual role, multi-level regulation, and new therapeutic strategies.

Lung cancer is a highly prevalent malignant tumor worldwide, with high incidence and death rates. Recently, there has been increasing recognition of the role of ferroptosis, a unique cell death mechanism, in lung cancer. This review aims to summarize the current research progress on the relationship between ferroptosis and lung cancer. It also provides a comprehensive analysis of the regulatory processes of ferroptosis in various stages, including epigenetics, transcription, post-transcription, translation, and post-translation. Additionally, the review explores the dual nature of ferroptosis in lung cancer progression, which presents interesting therapeutic possibilities. On one hand, ferroptosis can promote the escape of immune surveillance and reduce the efficacy of treatment in the early stages of tumors. On the other hand, it can counter drug resistance, enhance radiosensitivity, and promote immunotherapy. The article also discusses various combination treatment strategies based on the mechanism of ferroptosis. Overall, this review offers a holistic perspective on the role of ferroptosis in the onset, progression, and treatment of lung cancer. It aims to contribute to future research and clinical interventions in this field.

Switchable Anisotropic/Isotropic Photon Transport in a Double-Dipole Metal-Organic Framework via Radical-Controlled Energy Transfer.

Directional control of photon transport at micro/nanoscale holds great potential in developing multifunctional optoelectronic devices. Here, the switchable anisotropic/isotropic photon transport is reported in a double-dipole metal-organic framework (MOF) based on radical-controlled energy transfer. Double-dipole MOF microcrystals with transition dipole moments perpendicular to each other have been achieved by the pillared-layer coordination strategy. The energy transfer between the double dipolar chromophores can be modulated by the photogenerated radicals, which permits the in situ switchable output on both polarization (isotropy/anisotropy state) and wavelength information (blue/red-color emission). On this basis, the original MOF microcrystal with isotropic polarization state displays the isotropic photon transport and similar reabsorption losses at various directions, while the radical-affected MOF microcrystal with anisotropic polarization state shows the anisotropic photon transport with distinct reabsorption losses at different directions, finally leading to the in situ switchable anisotropic/isotropic photon transport. These results offer a novel strategy for the development of MOF-based photonic devices with tunable anisotropic performance.

Multistate structures in a hydrogen-bonded polycatenation non-covalent organic framework with diverse resistive switching behaviors.

The inherent structural flexibility and reversibility of non-covalent organic frameworks have enabled them to exhibit switchable multistate structures under external stimuli, providing great potential in the field of resistive switching (RS), but not well explored yet. Herein, we report the 0D+1D hydrogen-bonded polycatenation non-covalent organic framework (HOF-FJU-52), exhibiting diverse and reversible RS behaviors with the high performance. Triggered by the external stimulus of electrical field E at room temperature, HOF-FJU-52 has excellent resistive random-access memory (RRAM) behaviors, comparable to the state-of-the-art materials. When cooling down below 200 K, it was transferred to write-once-read-many-times memory (WORM) behaviors. The two memory behaviors exhibit reversibility on a single crystal device through the temperature changes. The RS mechanism of this non-covalent organic framework has been deciphered at the atomic level by the detailed single-crystal X-ray diffraction analyses, demonstrating that the structural dual-flexibility both in the asymmetric hydrogen bonded dimers within the 0D loops and in the infinite π-π stacking column between the loops and chains contribute to reversible structure transformations between multi-states and thus to its dual RS behaviors.

Profiles of phenolics and their synthetic pathways in Asparagus officinalis L.

The synthetic pathways of some phenolics compounds in asparagus have been reported, however, the diversified phenolics compounds including their modification and transcription regulation remains unknown. Thus, multi-omics strategies were applied to detect the phenolics profiles, contents, and screen the key genes for phenolics biosynthesis and regulation in asparagus. A total of 437 compounds, among which 204 phenolics including 105 flavonoids and 82 phenolic acids were detected with fluctuated concentrations in roots (Rs), spears (Ss) and flowering twigs (Fs) of the both green and purple cultivars. Based on the detected phenolics profiles and contents correlated to the gene expressions of screened synthetic enzymes and regulatory TFs, a full phenolics synthetic pathway of asparagus was proposed for the first time, essential for future breeding of asparagus and scaled healthy phenolics production using synthetic biological strategies.

Smart-Responsive HOF Heterostructures with Multiple Spatial-Resolved Emission Modes toward Photonic Security Platform.

Luminescent hydrogen-bonded organic frameworks (HOFs) with the unique dynamics and versatile functional sites hold great potential application in information security, yet most of responsive HOFs focus on the single-component framework with restrained emission control, limiting further applications in advanced confidential information protection. Herein, the first smart-responsive HOF heterostructure with multiple spatial-resolved emission modes for covert photonic security platform is reported. The HOF heterostructures are prepared by integrating different HOFs into a single microwire based on a hydrogen-bond-assisted epitaxial growth method. The distinct responsive behaviors of HOFs permit the heterostructure to simultaneously display the thermochromism via the framework transformation and the acidichromism via the protonation effect, thus generating multiple emission modes. The dual stimuli-controlled spatial-resolved emission modes constitute the fingerprint of a heterostructure, and enable the establishment of the smart-responsive photonic barcode with multiple convert states, which further demonstrate the dynamic coding capability and enhanced security in anticounterfeiting label applications. These results offer a promising route to design function-oriented smart responsive HOF microdevices toward advanced anticounterfeiting applications.

A Microporous Hydrogen-Bonded Organic Framework Based on Hydrogen-Bonding Tetramers for Efficient Xe/Kr Separation.

Hydrogen-bonded organic frameworks (HOFs) have been emerging as a new type of very promising microporous materials for gas separation and purification, but few HOFs structures constructed through hydrogen-bonding tetramers have been explored in this field. Herein, we report the first microporous HOF (termed as HOF-FJU-46) afforded by hydrogen-bonding tetramers with 4-fold interpenetrated diamond networks, which shows excellent chemical and thermal stability. What's more, activated HOF-FJU-46 exhibits the highest xenon (Xe) uptake of 2.51 mmol g-1 and xenon/krypton (Kr) selectivity of 19.9 at the ambient condition among the reported HOFs up to date. Dynamic breakthrough tests confirmed the excellent Xe/Kr separation of HOF-FJU-46a, showing high Kr productivity (110 mL g-1 ) and Xe uptake (1.29 mmol g-1 ), as well as good recyclability. The single crystal X-ray diffraction and the molecular simulations revealed that the abundant accessible aromatic and pyrazole rings in the pore channels of HOF-FJU-46a can provide the multiple strong C-H⋅⋅⋅Xe interactions with Xe atoms.

A Microporous Hydrogen Bonded Organic Framework for Highly Selective Separation of Carbon Dioxide over Acetylene.

The separation of acetylene (C2 H2 ) from carbon dioxide (CO2 ) is a very important but challenging task due to their similar molecular dimensions and physical properties. In terms of porous adsorbents for this separation, the CO2 -selective porous materials are superior to the C2 H2 -selective ones because of the cost- and energy-efficiency but have been rarely achieved. Herein we report our unexpected discovery of the first hydrogen bonded organic framework (HOF) constructed from a simple organic linker 2,4,6-tri(1H-pyrazol-4-yl)pyridine (PYTPZ) (termed as HOF-FJU-88) as the highly CO2 -selective porous material. HOF-FJU-88 is a two-dimensional HOFs with a pore pocket of about 7.6 Å. The activated HOF-FJU-88 takes up a high amount of CO2 (59.6 cm3 g-1 ) at ambient conditions with the record IAST selectivity of 1894. Its high performance for the CO2 /C2 H2 separation has been further confirmed through breakthrough experiments, in situ diffuse reflectance infrared spectroscopy and molecular simulations.

Photo Responsive Electron and Proton Conductivity within a Hydrogen-Bonded Organic Framework.

Rational design of crystalline porous materials with coupled proton-electron transfer has not yet been reported to date. Herein, we report a donor-acceptor (D-A) π-π stacking hydrogen-bonded organic framework (HOF; HOF-FJU-36) with zwitterionic 1,1'-bis(3-carboxybenzyl)-4,4'-bipyridinium (H2 L2+ ) as acceptor and 2,7-naphthalene disulfonate (NDS2- ) as donor to form a two-dimensional (2D) layer. Three water molecules were situated in the channels to connect with acidic species through hydrogen bonding interactions to give a 3D framework. The continuous π-π interactions along the a axis and the smooth H-bonding chain along the b axis provide the electron and proton transfer pathways, respectively. After 405 nm light irradiation, the photogenerated radicals could simultaneously endow HOF-FJU-36 with photoswitchable electron and proton conductivity due to coupled electron-proton transfer. By single-crystal X-ray diffraction (SCXRD) analyses, X-ray photoelectron spectroscopy (XPS), transient absorption spectra and density functional theory (DFT) calculations, the mechanism of the switchable conductivity upon irradiation has been demonstrated.

Optimized Sieving Effect for Ethanol/Water Separation by Ultramicroporous MOFs.

High-purity ethanol is a promising renewable energy resource, however separating ethanol from trace amount of water is extremely challenging. Herein, two ultramicroporous MOFs (UTSA-280 and Co-squarate) were used as adsorbents. A prominent water adsorption and a negligible ethanol adsorption identify perfect sieving effect on both MOFs. Co-squarate exhibits a surprising water adsorption capacity at low pressure that surpassing the reported MOFs. Single crystal X-ray diffraction and theoretical calculations reveal that such prominent performance of Co-squarate derives from the optimized sieving effect through pore structure adjustment. Co-squarate with larger rhombohedral channel is suitable for zigzag water location, resulting in reinforced guest-guest and guest-framework interactions. Ultrapure ethanol (99.9 %) can be obtained directly by ethanol/water mixed vapor breaking through the columns packed with Co-squarate, contributing to a potential for fuel-grade ethanol purification.

Partial Linker Substitution Strategy to Construct a Quaternary HKUST-like MOF for Efficient Acetylene Storage and Separation.

Multicomponent metal-organic frameworks (MOFs) have received much attention as emerging materials capable of precisely programing exquisite structures and specific functions. Here, we applied a partial linker substitution strategy to compile an HKUST-1-like quaternary MOF by introducing a bifunctional ligand into the well-known HKUST-1 structure. FUT-1, a new HKUST-like tbo topology MOF, was assembled with paddlewheel [Cu2(COO)4], triangular metallocycle pyrazole cluster Cu3(µ3-OH) (NN)3 building blocks, and two distinct linkers. FUT-1 exhibited good mechanical stability, water stability, and chemical stability (pH = 3-12) in aqueous solutions. Moreover, the porous environments created by this multicomponent primitive endow FUT-1 with high C2H2 storage and significantly selective separation performance of C2H2/CO2. Dynamic breakthrough experiments and ideal adsorbed solution theory calculations further demonstrate that FUT-1 can selectively capture C2H2 from C2H2/CO2 mixtures under ambient conditions. Based on grand canonical Monte Carlo simulations, the high C2H2 separation performance of FUT-1 is attributed to the π-complex formed between the C2H2 molecule and the trinuclear metallocycle clusters on the wall, which provides stronger affinity for C2H2 recognition than the CO2 molecule.

Coordination-Guided Conformational Locking of 1D Metal-Organic Frameworks for a Tunable Stimuli-Responsive Luminescence Region.

One-dimensional (1D) metal-organic frameworks (MOFs) have shown great potential for designing more sensitive and smart stimuli-responsive photoluminescence metal-organic frameworks (PL-MOFs). Herein, we propose a strategy for constructing the 1D MOFs with tunable stimuli-responsive luminescence regions based on coordination-guided conformational locking. Two flexible 1D MOF microcrystals with trans- and cis-coordination modes, respectively, were synthesized by controlling the spatial constraint of solvents. The two 1D frameworks possess different conformation lockings of gain ligands, which have a great influence on the rotating restrictions and corresponding excited-state behaviors, generating the remarkably distinct color-tunable ranges (cyan-blue to green and cyan-blue to yellow, respectively). On this basis, the two 1D MOF materials, benefiting from the varied stimuli-responsive ranges, have displayed great potential in fulfilling the anticounterfeiting and information encryption applications. These results provide valuable guidance for the development of smart MOF-based stimuli-responsive materials in information identification and data encryption.

A Microporous Hydrogen-Bonded Organic Framework for Efficient Xe/Kr Separation.

Separation of xenon/krypton gas mixtures is one of the valuable but challenging processes in the gas industries due to their close molecular size and similar physical properties. Here, we report a novel ultramicroporous hydrogen-bonded organic framework (termed as HOF-40) constructed from a cyano-based organic building unit of 1,2,4,5-tetrakis(4-cyanophenyl)benzene (TCPB), exhibiting superior separation performance for Xe/Kr mixtures, as clearly demonstrated by dynamic breakthrough curves. GCMC simulation results indicate that the pore confinement effect and abundant accessible binding sites play a synergistic role in this challenging gas separation. Furthermore, this cyano-based HOF displays excellent chemical stability from 12 M HCl to 20 M NaOH aqueous solutions.

Framework-Shrinkage-Induced Wavelength-Switchable Lasing from a Single Hydrogen-Bonded Organic Framework Microcrystal.

Porous organic materials (POMs) have shown great potential for fabricating tunable miniaturized lasers. However, most pure-POM micro/nanolasers are achieved via coordination interactions, during which strong charge exchanges inevitably destroy the intrinsic gain property and even lead to optical quenching, hindering their practical applications. Herein, we reported on an approach to realize hydrogen-bonded organic framework (HOF)-based in situ wavelength-switchable lasing based on the framework-shrinkage effect. A flexible HOF with reversible framework shrinkage was constructed from gain blocks with multiple rotors. The framework shrinkage of the HOF induced the in situ regulation on the conformation and conjugation degree of gain blocks, leading to distinct energy-level structures with blue/green-color gain emissions. Inspired by this, the in situ wavelength-switchable lasing from HOF microcrystals was achieved through reversibly controlling the framework shrinkage via the absorption/desorption of guests. The results offer useful insight into the use of flexible HOFs for exploiting miniaturized lasers with on-demand nanophotonics performance.

Birth Weight and Subsequent Risk of Total Leukemia and Acute Leukemia: A Systematic Review and Meta-Analysis.

Objective: Birth weight, an important indicator of fetal nutrition and degree of development, may affect the risk of subsequent leukemia. At present, little is known about the effect of birth weight on acute myeloid leukemia (AML) and whether there is a dose-dependent relationship of birth weight with acute lymphoid leukemia (ALL) and AML. To address these questions, the present work aimed to systematically investigate the relationship between birth weight and the risk of subsequent leukemia based on the current epidemiological studies Methods: Relevant studies were systematically retrieved from electronic databases PubMed, Embase, and Cochrane Library, from inception to May 15th, 2021. Finally, 28 studies (including 21 case-control studies and 7 cohort studies) were included for the final meta-analysis. Results in cohort studies were performed by risk ratios (RRs), while those in case-control studies by odds ratios (ORs), and all results were assessed by adopting the random-effect model. Besides, a dose-dependent analysis was conducted based on the cohort studies. Results: Compared with the population with normal birth weight (NBW), the population with high birth weight (HBW) might have an increased risk of leukemia (OR 1.33, 95%CI 1.20-1.49; I 2 0%). Meanwhile, low birth weight (LBW) was associated with a decreased risk of ALL, as evidenced from the pooled analysis of case-control studies (OR 0.83, 95% CI 0.75-0.92; I 2 23.3%). However, relative to NBW population, the HBW population might have an increased risk of ALL (OR 1.28, 95% CI 1.20-1.35; I 2 7%). There was no obvious evidence supporting the relationship between LBW and the risk of AML from the pooled analysis of case-control studies (OR, 1.11 95% CI 0.87-1.42; I 2 31.7%). Conclusions: Overall, in children and young adults, HBW population may be associated with the risks of subsequent leukemia and AML relative to NBW population, but the supporting dose-dependent evidence is lacking. In addition, compared with NBW population, there is stronger evidence supporting a significantly increased risk of subsequent ALL in HBW population, and a decreased risk in LBW population in a dose-dependent manner. More prospective studies with large samples are warranted in the future to validate and complement these findings.

Pure Metal-Organic Framework Microlasers with Controlled Cavity Shapes.

Metal-organic frameworks (MOFs) are an emerging kind of laser material, yet they remain a challenge in the controlled fabrication of crystal nanostructures with desired morphology for tuning their optical microcavities. Herein, the shape-engineering of pure MOF microlasers was demonstrated based on the coordination-mode-tailored method. The one-dimensional (1D) microwires and 2D microplates were selectively fabricated through changing the HCl concentration to tailor the coordination modes. Both the single-crystalline microwires and microplates with strong optical confinement functioned as low-threshold MOF microlasers. Moreover, distinct lasing behaviors of 1D and 2D MOF microcrystals confirm a typical shape-dependent microcavity effect: 1D microwires serve as Fabry-Pérot (FP) resonators, and 2D microplates lead to the whispering-gallery-mode (WGM) microcavities. These results provide a special pathway for the exploitation of MOF-based micro/nanolasers with on-demand functions.

Solvent-Assisted Modification to Enhance Proton Conductivity and Water Stability in Metal Phosphonates.

Although proton-conductive metal phosphonates with well-defined structure offer a favorable platform for exploring their structure-property relationship, investigating of the synergic effect of phosphonate groups and functional moieties on proton conduction is rare. In this work, we have synthesized two new copper phosphonates, [Cu(4-cppH)(4,4'-bipy)(H2O)3] (FJU-80) and [Cu(4-cppH)(4,4'-bipy)]·H2O·DMF (FJU-81), by the method of solvent-assisted modification, giving a 1D metal coordination polymer and a 3D metal open framework, respectively. Single-crystal X-ray diffraction shows that FJU-80 is full of hydrogen-bonding sites contributed from the improved synergic effect of phosphonate groups, carboxylate groups, and coordinated water molecules, thereby facilitating continuous hydrogen-bonding networks, whereas FJU-81 only has discrete hydrogen-bonding fragments. Powder X-ray diffraction and impedance analyses confirm that FJU-80 possesses higher water stability as well as improved proton conductivity, indicating that solvent-assisted modification is effective in increasing the hydrogen-bonding sites from phosphonate groups and functional moieties and then realizing facile proton transfer.

Local root growth and death are mediated by contrasts in nutrient availability and root quantity between soil patches.

Plants are thought to be able to regulate local root growth according to its overall nutrient status as well as nutrient contents in a local substrate patch. Therefore, root plastic responses to environmental changes are probably co-determined by local responses of root modules and systematic control of the whole plant. Recent studies showed that the contrast in nutrient availability between different patches could significantly influence the growth and death of local roots. In this study, we further explored, beside nutrient contrast, whether root growth and death in a local patch are also affected by relative root quantity in the patch. We conducted a split-root experiment with different splitting ratios of roots of Canada goldenrod (Solidago canadensis) individuals, as well as high- (5× Hoagland solution versus water) or low- (1× Hoagland solution versus water) contrast nutrient conditions for the split roots. The results showed that root growth decreased in nutrient-rich patches but increased in nutrient-poor patches when more roots co-occurred in the same patches, irrespective of nutrient contrast condition. Root mortality depended on contrasts in both root quantity and nutrients: in the high-nutrient-contrast condition, it increased in nutrient-rich patches but decreased in nutrient-poor patches with increasing root proportion; while in the low-nutrient-contrast condition, it showed the opposite trend. These results demonstrated that root growth and death dynamics were affected by the contrast in both nutrient availability and root quantity between patches. Our study provided ecological evidence that local root growth and death are mediated by both the responses of root modules to a nutrient patch and the whole-plant nutrient status, suggesting that future work investigating root production and turnover should take into account the degree of heterogeneity in nutrient and root distribution.