Isolation and structure elucidation of 12beta-acetoxycoccinic Acid, 12beta-hydroxycoccinic Acid, 12alpha-acetoxycoccinic Acid, and 12alpha-hydroxycoccinic acid1.

Four new triterpenoid acids, possessing a lanost-9(11)-en-3-one skeleton, were isolated from KADSURA HETEROCLITA. Based on chemical and spectral analyses, they were assigned as 12beta-acetoxycoccinic acid, 12beta-hydroxycoccinic acid, 12alpha-acetoxycoccinic acid, and 12alpha-hydroxycoccinic acid.

Triterpenoid Acids from Kadsura longipedunculata. Neokadsuranic Acids B and C: Two Novel Triterpenoids with 14 (13 --> 12)abeo-Lanostane Skeletons.

Six triterpenoid acids were isolated from the stems of KADSURA LONGIPEDUNCULATA, collected in Kuangxi province. Four of them were new compounds and assigned as (24 Z)-3-oxo-12alpha-acetoxylanosta-8,24-dien-26-oic acid ( 1), (24 Z)-3-oxo-12alpha-hydroxylanosta-8,24-dien-26-oic acid ( 2), (24 Z)-3-oxo-14(13-->12) ABEO-lanosta-8,13(18),24-trien-26-oic acid ( 3), and (24 Z)-3-oxo-13beta-hydroxy-14(13-->12) ABEO-lanosta-8,24-dien-26-oic acid ( 4). Compounds 3 and 4 were named neokadsuranic acids B and C, respectively.

Isolation and Structure Elucidation of Neokadsuranic Acid A, the First Triterpenoid with the 14 (13-->12) abeo Lanostane Skeleton, and (24Z)-3-Oxo-lanosta-8,24-dien-26-oic Acid1.

Neokadsuranic acid A, which is the first triterpenoid with the 14(13-->12) ABEO lanostane skeleton, was isolated from KADSURA HETEROCLITA together with (24 Z)-3-oxo-lanosta-8,24-dien-26-oic acid. The present paper deals with the isolation and structure elucidation of these two new compounds.

Isolation and Structure Elucidation of Seco-neokadsuranic Acid A and 3,4-Seco-(24Z)-lanosta-4(30),8,24-triene-3,26-dioic Acid1.

Seco-neokadsuranic acid A, the second natural triterpenoid with the unusual 14(13-->12) ABEO-lanostane skeleton was isolated from KADSURA HETEROCLITA together with 3,4-seco-(24 Z)-lanosta-4(30),8,24,triene-3,26-dioic acid. The present paper deals with the isolation and structure elucidation of these two new compounds and the preparation of two new 7-oxo-lanostane triterpenoid derivatives.

Neokadsuranin, a Tetrahydrofuranoid Dibenzocyclooctadiene Lignan from Stems of Kadsura coccinea.

A tetrahydrofuranoid dibenzocyclooctadiene lignan, which we name neokadsuranin, was isolated from the stems of Kadsura coccinea, collected in Kuangxi, China. The absolute configuration was elucidated by spectral analysis.

Triterpenoids from Roots and Stems of Kadsura coccinea.

24-Methylenecycloartenone ( 1), kadsuric acid ( 2) and a new triterpenoid acid named coccinic acid ( 3A) were isolated from the ether soluble fraction of the dried roots and stems of KADSURA COCCINEA.

Henricine, a New Tetrahydrofuran Lignan from Schisandra henryi.

A new tetrahydrofuran lignan, named henricine ( 1), was isolated from the stems of SCHISANDRA HENRYI. High resolution COSY spectrum was used in the structural elucidation.

Dibenzocyclooctadiene Lignans from Roots and Stems of Kadsura coccinea.

Ten dibenzocyclooctadiene lignans were obtained from the ethereal soluble fraction of the dried roots and stems of KADSURA COCCINEA. Two of them were new compounds, named kadsutherin ( 8) and isokadsuranin ( 10). Their structures were elucidated on the basis of chemical and spectral analysis.

Studies on the Chemical Constituents of Kadsura longipedunculata: Isolation and Structure Elucidation of Five New Lignans.

Five new dibenzocyclooctadiene lignans, R(+)-wuweizisu C ( 1), kadsuranin ( 2), R(+)-gomisin M (1) ( 3), R(+)-angeloylgomisin M (1) ( 4) and angeloylgomisin R ( 5) were isolated from the ethereal extract of roots and stems of KADSURA LONGIPEDUNCULATA Finet et Gagnep. Their structures were elucidated on the basis of chemical and spectral analysis.

Salvianolic Acid A, a New Depside from Roots of Salvia miltiorrhiza.

A new depside of D-(+)-beta-(3,4-dihydroxyphenyl)-lactic acid and 2-(3,4-dihydroxyphenylethenyl)-caffeic acid, named salvianolic acid A, was isolated from the dried roots of SALVIA MILTIORRHIZA Bunge. Its chemical structure was defined by spectral analysis and chemical degradation.

Studies of Fructus schizandrae. IV. Isolation and determination of the active compounds (in lowering high SGPT levels) of Schizandra chinensis Baill.

The alcoholic extracts of the kernels of Schizandra chinensis Baill have been reported to be capable of lowering elevated SGPT levels in mice induced by CCl4 and inhibiting the central nervous system. Seven pharmacological active compounds have been isolated from the alcoholic extracts by column chromatography. Five of them are identified as wuweizisu C (I), wuweizisu B (II), wuweizisu A (III), wuweizichun B (IV) and wuweizichun A (V). They are all derivatives of the dibenzo (a, c) cyclooctene system, among which compounds I and IV have hitherto not been reported in literature. Ozonolysis of III and subsequent oxidation with H2O2 yields meso-3,4-dimethyladipic acid. Pyrolytic syn-elimination of V acetate and oxidation of the resultant olefin (V-4) affords a diketone (V-5) with molecular weight of 446. According to these results and based on the NMR spectra, the two methyl groups at C-6 and C-7 of compound I--V must be cis-oriented.