RESUMEN
The negative effect of photoinduced halide segregation (PIHS) on the properties of hybrid halide perovskites poses a major obstacle for its future commercial application. Therefore, the in-depth understanding of halide-ion segregation and its causes is an urgent and intractable problem. When PIHS reaches a certain threshold, it will aggravate the deterioration of the film surface morphology and form nanoscale cracks. Herein, the formation mechanism and types of cracks are revealed by exploring the stress distribution in the film. Using the femtosecond time-resolved transient absorption spectroscopy, the ultrafast formation of the iodine rich phase is observed, which appears earlier than the bromine rich phase. In addition, the introduction of organic ligand didodecyldimethylammonium bromide can significantly inhibit PIHS and improve the surface morphology of the film, which can promote the device efficiency from 9.63 to 11.20%. This work provides a novel perspective for the exploration of the PIHS.
RESUMEN
Detecting acoustic signals in the ocean is crucial for port and coastal security, but existing methods often require informative priors. This paper introduces a new approach that transforms acoustic signal detection into network characterization using a MCN construction method. The method constructs a network representation of the acoustic signal by measuring pairwise correlations at different time scales. It proposes a network spectrum distance method that combines information geometry and graph signal processing theory to characterize these complex networks. By comparing the spectra of two networks, the method quantifies their similarity or dissimilarity, enabling comparisons of multi-scale correlation networks constructed from different time series data and tracking changes in nonlinear dynamics over time. The effectiveness of these methods is substantiated through comprehensive simulations and real-world data collected from the South China Sea. The results illustrate that the proposed approach attains a significant detection probability of over 90% when the signal-to-noise ratio exceeds -18 dB, whereas existing methods require a signal-to-noise ratio of at least -15 dB to achieve a comparable detection probability. This innovative approach holds promising applications in bolstering port security, facilitating coastal operations, and optimizing offshore activities by enabling more efficient detection of weak acoustic signals.
RESUMEN
Differentiation therapy using small molecules is a promising strategy for improving the prognosis of glioblastoma (GBM). Histone acetylation plays an important role in cell fate determination. Nevertheless, whether histone acetylation in specific sites determines GBM cells fate remains to be explored. Through screening from a 349 small molecule-library, we identified that histone deacetylase inhibitor (HDACi) MS-275 synergized with 8-CPT-cAMP was able to transdifferentiate U87MG GBM cells into neuron-like cells, which were characterized by cell cycle arrest, rich neuron biomarkers, and typical neuron electrophysiology. Intriguingly, acetylation tags of histone 3 at lysine 9 (H3K9ac) were decreased in the promoter of multiple oncogenes and cell cycle genes, while ones of H3K9ac and histone 3 at lysine 14 (H3K14ac) were increased in the promoter of neuron-specific genes. We then compiled a list of genes controlled by H3K9ac and H3K14ac, and proved that it is a good predictive power for pathologic grading and survival prediction. Moreover, cAMP agonist combined with HDACi also induced glioma stem cells (GSCs) to differentiate into neuron-like cells through the regulation of H3K9ac/K14ac, indicating that combined induction has the potential for recurrence-preventive application. Furthermore, the combination of cAMP activator plus HDACi significantly repressed the tumor growth in a subcutaneous GSC-derived tumor model, and temozolomide cooperated with the differentiation-inducing combination to prolong the survival in an orthotopic GSC-derived tumor model. These findings highlight epigenetic reprogramming through H3K9ac and H3K14ac as a novel approach for driving neuron-fate-induction of GBM cells.
