[Experimental evaluation of combined effects caused by stress and metals (cadmium and aluminium) in reproductivity of male rats].

To investigate combined effects of stress and metal (aluminium, cadmium) on reproductivity, male rats twice per week received intraperitoneal injections of aluminium (3.8 mg Al3+ per kg of body weight) or cadmium (0.3 mg Cd2+ per kg of body weight) and were subjected to stress via short-term immobilization during spermatogenic cycle (54 +/- 3 days). Findings are cumulation of both cadmium and aluminium in genitals and brain, increasing under stress. When acting separately to the laboratory animals, the three factors (aluminium/cadmium/stress) increase serum corticosterone level, change testosterone level, increase number of aberrant mitoses of spermatogenic epithelium cells, increased sperm count with fragmented DNA, lower percentage of the impregnated females. If the exposure combined with stress, spermatogenesis disorders are more marked, and preimplantation death rate of intact females' offspirngs becomes statistically significant.

[Aerogenic risk factors and diagnosis of bauxite pneumoconiosis].

The research purpose is an estimation of influence of the bauxite dust on the state of the bronchopulmonary system of workers. It has been indicated that exposure of the poor fibrogenic dust while the process of the bauxite ore extraction, results in development of pnevmokoniosis characterized by substantial ventilatory and haemodynamic disorders limiting the workability of patients.

[Clinical and pathogenetic aspects of the chronic occupational intoxication with fluorine compounds in modern reality].

Multi-year follow-up of 358 workers of aluminum pot rooms, including 165 individuals suffering from fluorosis, has shown significant changes in the clinical picture of the chronic occupational fluorine intoxication, developed under modern conditions of production, at lower concentrations of fluorine compounds in the air of working area. In this connection, the pathology of the musculoskeletal system plays the dominating role in this clinical picture and has the large variability of combinations of the individual sections destructions of the bone tissue. The main criterion to establish the phase of the disease is still the number and severity of the signs of this destruction. The visceral pathology in contemporary production circumstances is registered with less frequency and loses a number of the previously described clinical manifestations, however, is still of some importance to identify the early signs of the disease and to prevent the dental fluorosis on time.

[Biologic markers of exposure to and effects of fluorine compounds in workers engaged into aluminum industry].

The study in 727 workers exposed to inorganic fluorine compounds revealed through ultrasound densitometry changes in fluorine excretion and bone tissue density in accordance with the length of service, through markers of bone destruction and synthesis features of bone remodelling were specified.

[Health and life quality of workers in industrial Urals region].

The authors present data on occupational morbidity among workers of Urals area, life quality of the workers in some economic branches, on work process role in chronoalgorithm of body systems functioning. Suggestions cover a variant of program aimed to preventive therapy and preservation of healthy lifestyle.

[Symptoms of asbestos-related diseases and correction of hemodynamic and ventilation changes in asbestosis patients].

The authors present results of thorough examination of asbestosis and dust bronchitis patients, features of dust load and X-ray functional changes, efficiency of physical therapy complexes in correcting cardio-pulmonary syndrome.

[Assessment and management of risk to the working population's health in the occupational medicine system].

The multidisciplinary harmonized "Occupational Medicine" system established in the Sverdlovsk Region makes it possible, firstly, to analyze and assess occupational risks at both the regional and municipal levels; secondly, at each of the above level, to take specific managerial decisions including the packages of organizational, informational, preventive, and other measures to minimize risks on the cost-benefit basis.

[The results of studies of the effect of asbestos on the health of working people and the population, conducted by the Yekaterinburg Medical Research Center].

The paper presents the basic results of 75-year studies of the Yekaterinburg Medical Research Center to evaluate the effect of asbestos on the health status of working people and the population, which have yielded basic hygienic, sanitary, clinical, epidemiological, and experimental data on the effect of asbestos on the health status of working people and the population and led to the conclusion that the center's experience in studying the problems may serve as the real basis for substantiating the safe permissible controlled use of chrysotile asbestos.

[Medical technologies for prophylaxis and health preservation for workers, within realization of national projects].

The authors present principles underlying development of technologies for prevention and rehabilitation of occupational diseases. Those technologies prevent occupational diseases in workers exposed to occupational hazards, reduce hospital stays, disablement duration and increase remission.

["Industrial Hygiene" system as a basis of medical service for workers in Sverdlovsk region]. / Sistema "Meditsina truda" kak osnova meditsinskogo obsluzhivaniia rabotaiushchikh Sverdlovskoi oblasti.

The authors suggest a concept of multifield specialized "Industrial Hygiene" service based on integrated system of medical and social care, that includes monitoring of work conditions, evaluation of occupational risk and its management for prevention of and lowering general and occupational morbidity, transitory disablement morbidity, disability and premature deaths, for preservation of labour force in Sverdlovsk region.

[Contemporary problems of asbestos and prospective research directions]. / Sovremennye problemy asbesta i perspektivnye napravleniia issledovanii.

The authors determined prospective directions in researchon asbestos problem--risk evaluation, early diagnosis and physiotherapy of asbestos-related diseases; sanitary and epidemiologic well-being of population influenced by enterprises extracting and concentration of asbestos; evaluation of new production and development of legal regulation of safety for work with natural and artificial mineral fibers.

[Priority topics of industrial medicine in production and processing of nonferrous metals alloys]. / Prioritetnye voprosy meditsiny truda v proizvodstve i obrabotke splavov tsvetnykh metallov.

The authors present general characteristics of nonferrous metals alloys production: work conditions, health state of workers, main directions to make healthier work conditions.

[Features of chronic occupational bronchitis in nonferrous metallurgy workers]. / Osobennosti khronicheskogo professional'nogo bronkhita u rabochikh proizvodstsv tsvetnoi metallurgii.

The authors summarized results of periodic medical examinations and deep clinical studies of metallurgy workers with bronchial and pulmonary disorders. The article covers clinical and functional characteristics of toxic and dust bronchitis, clinical course and manifestations.

[Structural organization of blood serum in occupational respiratory diseases]. / Strukturnaia organizatsiia syvorotki krovi pri professional'noi patologii organov dykhaniia.

The authors demonstrated that in workers having pulmonary dust diseases, serum blood dehydration ("closed drop" preparation) reveals in polarized light very specific structure different from that in the reference group members. Morphologic properties of various structures could prove silicotic process development.

[Efficacy of therapeutic use of ultrasound and sinusoidal modulated currents combed with halotherapy in patient with occupational toxic-dust bronchitis]. / Effektivnost' lechebnogo primeneniia ul'trazvuka i sinusoidal'nykh modulirovannykh tokov v komplekse s galoterapie u bol'nykh professional'nym toksiko-pylevym bronkhitom.

Immunological and cardiorespiratory characteristics were studied in 88 alloy industry workers with occupational toxic-dust bronchitis who received the following therapy: sinusoidal modulated currents (SMC), ultrasound (US) on the chest, halotherapy (HT) (52 patients, group 1); SMC + HT (10 patients, group 2); US + HT (15 patients, group 3); HT (11 patients, group 4). The patients did also therapeutic exercise and were massaged (chest). It was found that device physiotherapy (SMC, US) in combination with HT raise the treatment efficacy to 86.5%. This combined treatment is recommended both for treatment and prevention of obstructive syndrome in toxic-dust bronchitis.

[Clinical and x-ray diagnosis and diagnosis and classification of occupational fluorosis]. / Kliniko-rentgenologicheskaia diagnostika i klassifikatsiia professional'nogo fliuoroza.

The authors summarize longstanding experience in studies of chronic occupational intoxication caused by fluoric compounds. Findings are that diagnosis and clinical classification of occupational fluorosis should base on osteosclerotic changes in compact substance of peripheral bones, primarily of forearms and legs. The authors give clinical classification of occupational fluorosis.

[Asbestos: contemporary problems of industrial medicine and ecology]. / Asbest -- sovremennye problemy meditsiny truda i ékologii.

The article covers main steps of research work conducted by Ekaterinbourg Medical Research Center and determines contemporary problems of asbestos. The authors list priority directions of ecologic and hygienic research on the "Asbestos and Health" problem.

[Clinical features of pulmonary diseases caused by chrysotile asbestos dust]. / Klinicheske osobennosti zabolevanii legkikh ot vozdeistviia pyli khrizotil-asbesta.

The authors studied clinical, roentgenologic and functional signs of asbestosis and chronic dust bronchitis in 57 workers engaged into extraction and processing of asbestos. Occupational peripheral lung cancer was revealed in 4 cases. Chronic dust bronchitis appeared to be diagnosed with delay, usually at I-II stages.