Radiomic Analysis Based on Gd-EOB-DTPA Enhanced MRI for the Preoperative Prediction of Ki-67 Expression in Hepatocellular Carcinoma.

RATIONALE AND OBJECTIVES: To develop and validate a random forest model based on radiomic features in Gd-EOB-DTPA enhanced MRI for predicting the Ki-67 expression in solitary HCC. MATERIALS AND METHODS: This retrospective study analyzed 258 patients with solitary HCC. Significant clinicoradiological factors were identified through univariate and multivariate analyses for distinguishing HCC with high (>20%) and low (≤20%) Ki-67 expression. Radiomic features were extracted at Gd-EOB-DTPA enhanced MRI. The recursive feature elimination (RFE) strategy was employed to screen robust radiomic features, and the Random Forest (RF) algorithm was utilized to rank radiomic features and construct prediction models. The AUC, accuracy, precision, recall, and f1-score were used to evaluate the performance of RF models. RESULTS: Multivariate analysis identified serum AFP level, tumor size, growth type, and peritumoral enhancement as independent predictors for HCC with high Ki-67 expression. The clinicoradiological-radiomic model that incorporated the clinicoradiological predictors and the top ten radiomic features outperformed the clinicoradiological model in the training set (AUCs 0.876 vs. 0.780; p < 0.001), though the test set did not have a statistical significance (AUCs 0.809 vs. 0.723; p = 0.123). The addition of clinicoradiological predictors did not yield a significant improvement in the performance of radiomic features in both sets (training, p = 0.692; test, p = 0.229). Decision curve analysis further confirmed the clinical utility of the RF models. CONCLUSION: The RF models based on radiomic features of Gd-EOB-DTPA enhanced MRI achieved satisfactory performance in preoperatively predicting Ki-67 expression in HCC.

Clinical effect of Danhong injection combined with rehabilitation exercise on acute cerebral infarction and its effect on motor function / 中国生化药物杂志

Objective To investigate the effect of Danhong injection combined with rehabilitation exercise on patients with acute cerebral infarction and its influence on the motor function of the patients. Methods 80 patients with acute cerebral infarction admitted to Jiaxing Hospital from January 2017 to July 2017 were randomly divided into two groups (n=40), the two groups were given rehabilitation exercises, the control group was given conventional treatment, and the observation group was treated with Danhong injection on the basis of the control group. The clinical efficacy, motor function score before and after treatment were compared between the two groups. Results The total efficiency of the observation group was 92.50%, significantly higher than 80.00% in the control group (P<0.05). The FMA score and MBI score of the two groups after treatment were significantly improved (P<0.05), and the observation group was higher than that of the control group (P<0.05). There were no serious adverse reactions such as liver and kidney dysfunction in the two groups during the treatment. Conclusion Rehabilitation exercise combined with Danhong injection is effective in the treatment of acute cerebral infarction, and can significantly improve the motor function of patients.

Clinical effect of Danhong injection combined with rehabilitation exercise on acute cerebral infarction and its effect on motor function / 中国生化药物杂志

Objective To investigate the effect of Danhong injection combined with rehabilitation exercise on patients with acute cerebral infarction and its influence on the motor function of the patients. Methods 80 patients with acute cerebral infarction admitted to Jiaxing Hospital from January 2017 to July 2017 were randomly divided into two groups (n=40), the two groups were given rehabilitation exercises, the control group was given conventional treatment, and the observation group was treated with Danhong injection on the basis of the control group. The clinical efficacy, motor function score before and after treatment were compared between the two groups. Results The total efficiency of the observation group was 92.50%, significantly higher than 80.00% in the control group (P<0.05). The FMA score and MBI score of the two groups after treatment were significantly improved (P<0.05), and the observation group was higher than that of the control group (P<0.05). There were no serious adverse reactions such as liver and kidney dysfunction in the two groups during the treatment. Conclusion Rehabilitation exercise combined with Danhong injection is effective in the treatment of acute cerebral infarction, and can significantly improve the motor function of patients.