Periodontium-Mimicking, Multifunctional Biomass-Based Hydrogel Promotes Full-Course Socket Healing.

Preserving stable tooth-periodontal tissue integration is vital for maintaining alveolar bone stability under physiological conditions. However, tooth extraction compromises this integration and impedes socket healing. Therefore, it becomes crucial to provide early stage coverage of the socket to promote optimal healing. Drawing inspiration from the periodontium, we have developed a quaternized methacryloyl chitosan/dopamine-grafted oxidized sodium alginate hydrogel, termed the quaternized methacryloyl chitosan/dopamine-grafted oxidized sodium alginate hydrogel (QDL hydrogel). Through blue-light-induced cross-linking, the QDL hydrogel serves as a comprehensive wound dressing for socket healing. The QDL hydrogel exhibits remarkable efficacy in closing irregular tooth extraction wounds. Its favorable mechanical properties, flexible formability, and strong adhesion are achieved through modifications of chitosan and sodium alginate derived from biomass sources. Moreover, the QDL hydrogel demonstrates a superior hemostatic ability, facilitating swift blood clot formation. Additionally, the inherent antibacterial properties of the QDL hydrogel effectively inhibit oral microorganisms. Furthermore, the QDL hydrogel promotes angiogenesis, which facilitates the nutrient supply for subsequent tissue regeneration. Notably, the hydrogel accelerates socket healing by upregulating the expression of genes associated with wound healing. In conclusion, the periodontium-mimicking multifunctional hydrogel exhibits significant potential as a clinical tooth extraction wound dressing.

A facile approach for sulphur and nitrogen co-doped carbon nanodots to improve photothermal eradication of drug-resistant bacteria.

In this study, we produced S, N co-doped CNDs (SN@CNDs) by using dimethyl sulfoxide (DMSO) and formamide (FA) as single sources of S and N, respectively. We varied the S/N ratios by adjusting the volume ratios of DMSO and FA and investigated their effect on the red-shift of the CNDs' absorption peak. Our findings demonstrate that SN@CNDs synthesized using a volume ratio of 5:6 between DMSO and FA exhibit the most significant absorption peak redshift and enhanced near-infrared absorption performance. Based on comparative analysis of the particle size, surface charge, and fluorescence spectrum of the S@CNDs, N@CNDs, and SN@CNDs, we propose a possible mechanism to explain the change of optical properties of CNDs due to S, N doping. Co-doping creates a more uniform and smaller band gap, resulting in a shift of the Fermi level and a change in energy dissipation from radioactive to non-radiative decay. Importantly, the as-prepared SN@CNDs exhibited a photothermal conversion efficiency of 51.36% at 808 nm and demonstrated exceptional photokilling effects against drug-resistant bacteria in both in vitro and in vivo experiments. Our facile method for synthesizing S and N co-doped CNDs can be extended to the preparation of other S and N co-doped nanomaterials, potentially improving their performance.