[Treatment of acute inflammatory pathology of the upper airway with morniflumate]. / Trattamento delle patologie infiammatorie acute delle vie aeree superiori con morniflumato.

Sixty patients, 33 men and 27 women (mean age about 45 years; range 25-60), affected by acute influenza syndrome of the upper airways were admitted to a controlled single-blind study with three drugs under parallel conditions. According to a balanced randomized sequence, the subjects were treated over a 7-10 day period with morniflumate sachets (700 mg bid) or with tiaprofenic acid sachets (300 mg bid) or with paracetamol (10 ml syrup equivalent to 500 mg tid). The efficacy of the test drugs was assessed by determining the local and general signs and symptoms before starting the treatments, in basal conditions, and on the 3rd, 5th and last day of treatment. At the doses and formulations used, morniflumate proved to be equivalent to paracetamol and more effective than tiaprofenic acid as for its antipyretic action in the first days of treatment. On the other hand, both morniflumate and tiaprofenic acid showed a significantly higher antiinflammatory effect compared to paracetamol. Pain was effectively and equally controlled in all the treatment groups. The drugs administered were generally well tolerated. A greater incidence of adverse GI events was reported in the group treated with tiaprofenic acid.

[Frequency and characters of familial pulmonary sarcoidosis (author's transl)]. / Fréquence et caractères de la sarcoïdose pulmonaire familiale.

A report is given on familial sarcoidosis in four cases. These 4 cases comprise one brother-sister and one mother-son relationship. Brother and sister were young persons in the acute stage (Löfgren-syndrome). In the other two cases diffuse fibroses accompanied by severe functional disturbances were to be observed. In both relationships clinical and radiological picture, course of the illness and response to the treatment were similar: favourable in the first, unfavourable in the second relationship. The frequency of familial occurrence is said to be 3.7% of all sarcoidosis cases.