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1.
Actas Dermosifiliogr ; 101(2): 129-42, 2010 Mar.
Artículo en Español | MEDLINE | ID: mdl-20223155

RESUMEN

The consensus statement on the management of primary cutaneous melanoma that we present here was based on selection, discussion, review, and comparison of recent literature (including national and international guidelines). The protocols for the diagnosis, treatment, and follow-up used in the hospital centers throughout Catalonia and the Balearic Isles belonging to the Network of Catalan and Balearic Melanoma Centers were also considered. The main objective of this statement was to present the overall management of melanoma patients typically used in our region at the present time. As such, the statement was not designed to be an obligatory protocol for health professionals caring for this group of patients, and neither can it nor should it be used for this purpose. Professionals reading the statement should not therefore consider it binding on their practice, and in no case can this text be used to guarantee or seek responsibility for a given medical opinion. The group of dermatologists who have signed this statement was created 3 years ago with the aim of making our authorities aware of the importance of this complex tumor, which, in comparison with other types of cancer, we believe does not receive sufficient attention in Spain. In addition, the regular meetings of the group have produced interesting proposals for collaboration in various epidemiological, clinical, and basic applied research projects on the subject of malignant melanoma in our society.


Asunto(s)
Melanoma , Neoplasias Cutáneas , Adulto , Antineoplásicos/uso terapéutico , Biopsia , Vacunas contra el Cáncer/uso terapéutico , Quimioterapia Adyuvante , Terapia Combinada , Femenino , Humanos , Factores Inmunológicos/uso terapéutico , Inmunoterapia , Metástasis Linfática , Masculino , Melanoma/diagnóstico , Melanoma/patología , Melanoma/secundario , Melanoma/terapia , Persona de Mediana Edad , Estadificación de Neoplasias , Cuidados Paliativos , Manejo de Atención al Paciente , Examen Físico , Radioterapia Adyuvante , Sistema de Registros , Biopsia del Ganglio Linfático Centinela , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/terapia
2.
Actas dermo-sifiliogr. (Ed. impr.) ; 101(2): 129-142, mar. 2010. tab
Artículo en Español | IBECS | ID: ibc-78490

RESUMEN

El documento de consenso respecto al manejo del melanoma primario de la piel, que detallamos a continuación, nace de la puesta en común, aceptación, revisión y confrontación con la literatura reciente (incluyendo guías clínicas nacionales e internacionales), así como de los protocolos de diagnóstico, seguimiento y tratamiento consensuados en los diferentes centros hospitalarios de toda Cataluña y Balerares pertenencientes a la Xarxa de Centres de Melanoma de Catalunya i Balears. El objetivo principal de este documento es exponer de forma conjunta el manejo habitual del paciente con melanoma que actualmente se realiza en nuestro medio. Sin embargo, este documento no pretende, ni puede, por lo que tampoco debiera ser usado como un protocolo de obligado cumplimiento por los profesionales que atendemos a este grupo de enfermos. En este sentido, cabe mencionar que la consulta de este documento por parte del profesional no es vinculante para su acción, y en ningún caso este texto podrá ser utilizado para garantizar o buscar responsabilidades del juicio médico concreto. El grupo de dermatólogos que firman dicho documento se formó hace ahora tres años, con la intención de dar a conocer a nuestras autoridades la importancia de este complejo tumor, que en nuestro país creemos que se encuentra erróneamente infravalorada con respecto a otros tipo de cáncer. Además, fruto de las reuniones periódicas del grupo, han surgido también interesantes propuestas de colaboración en distintos proyectos de investigación epidemiológica, clínica y básica aplicada en torno al melanoma maligno en nuestra sociedad (AU)


The consensus statement on the management of primary cutaneous melanoma that we present here was based on selection, discussion, review, and comparison of recent literature (including national and international guidelines). The protocols for the diagnosis, treatment, and follow-up used in the hospital centers throughout Catalonia and the Balearic Isles belonging to the Network of Catalan and Balearic Melanoma Centers were also considered. The main objective of this statement was to present the overall management of melanoma patients typically used in our region at the present time. As such, the statement was not designed to be an obligatory protocol for health professionals caring for this group of patients, and neither can it nor should it be used for this purpose. Professionals reading the statement should not therefore consider it binding on their practice, and in no case can this text be used to guarantee or seek responsibility for a given medical opinion. The group of dermatologists who have signed this statement was created 3 years ago with the aim of making our authorities aware of the importance of this complex tumor, which, in comparison with other types of cancer, we believe does not receive sufficient attention in Spain. In addition, the regular meetings of the group have produced interesting proposals for collaboration in various epidemiological, clinical, and basic applied research projects on the subject of malignant melanoma in our society (AU)


Asunto(s)
Humanos , Masculino , Femenino , Sarcoma de Células Claras/diagnóstico , Sarcoma de Células Claras/terapia , Melanoma/diagnóstico , Melanoma/terapia , Estadificación de Neoplasias/métodos , Estadificación de Neoplasias/normas , Neoplasias Cutáneas/complicaciones , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/terapia , Interferones/uso terapéutico , Estadificación de Neoplasias/tendencias , Biopsia , Escisión del Ganglio Linfático/métodos , Escisión del Ganglio Linfático/tendencias , Quimioterapia Adyuvante , Radioterapia Adyuvante/tendencias
3.
5.
J Am Acad Dermatol ; 42(2 Pt 2): 324-8, 2000 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-10640924

RESUMEN

We describe a 76-year-old woman who presented persistent generalized pruritus as the only cutaneous manifestation of a cutaneous T-cell lymphoma (mycosis fungoides). No cutaneous lesions were observed throughout the patient's course. Skin biopsies obtained from normal-looking pruritic skin revealed a discrete perivascular lymphocytic infiltrate in the upper dermis and focal intraepidermal clusters of atypical lymphoid cells (Pautrier's microabscesses). PCR analysis of TCR-gamma gene disclosed a monoclonal T-cell rearrangement. Sequencing of the PCR monoclonal product identified the J(8)V(2)C(2) TCR gene rearrangement. This observation illustrates the existence of a peculiar and exceedingly rare form of mycosis fungoides characterized only by persistent pruritus unresponsive to several therapeutic approaches. The diagnostic difficulties of this rare variant are stressed.


Asunto(s)
Micosis Fungoide/diagnóstico , Neoplasias Cutáneas/diagnóstico , Anciano , Femenino , Humanos , Inmunohistoquímica , Micosis Fungoide/complicaciones , Micosis Fungoide/metabolismo , Micosis Fungoide/patología , Reacción en Cadena de la Polimerasa , Prurito/etiología , Piel/patología , Neoplasias Cutáneas/complicaciones , Neoplasias Cutáneas/metabolismo , Neoplasias Cutáneas/patología
7.
Pediatr Dermatol ; 14(3): 216-8, 1997.
Artículo en Inglés | MEDLINE | ID: mdl-9192416

RESUMEN

We describe a typical case of lipodystrophia centrifugalis abdominalis infantilis. This rare disorder is almost exclusively seen in Japanese children. The patient, a 3-year-old girl of Chinese ancestry, had a depressed area of skin in the right groin which gradually spread across the abdomen. The lesion had a distinctive, slightly erythematous, raised border and regional lymphadenopathy was present.


Asunto(s)
Lipodistrofia , Abdomen , Preescolar , Femenino , Humanos , Lipodistrofia/tratamiento farmacológico , Lipodistrofia/patología
9.
Rev Neurol ; 23(124): 1236-8, 1995.
Artículo en Español | MEDLINE | ID: mdl-8556627

RESUMEN

We report a 18 years old female with Lennox-Gastaut syndrome under treatment with sodium valproate, carbamazepine and clonazepam. When seizures increased we stopped carbamazepine and introduced lamotrigine slowly. One month later the girl developed haemorrhagic erosions in mucoses and limbs with deterioration of her general state. Skin biopsy confirmed the diagnosis of erythema multiforme, the Stevens-Johnson's form. The immediate withdrawal of lamotrigine and treatment with antihystaminics and steroids was followed of a slowly favourable course with disappearance of symptomatology one month later. It's another case of Stevens-Johnson syndrome related to the introduction of lamotrigine in polytherapy.


Asunto(s)
Anticonvulsivantes/efectos adversos , Síndrome de Stevens-Johnson/etiología , Triazinas/efectos adversos , Adolescente , Anticonvulsivantes/administración & dosificación , Anticonvulsivantes/uso terapéutico , Carbamazepina/administración & dosificación , Carbamazepina/uso terapéutico , Clonazepam/administración & dosificación , Clonazepam/uso terapéutico , Relación Dosis-Respuesta a Droga , Quimioterapia Combinada , Epidermis/patología , Epidermis/ultraestructura , Epilepsia/tratamiento farmacológico , Femenino , Humanos , Lamotrigina , Necrosis/patología , Síndrome de Stevens-Johnson/patología , Triazinas/administración & dosificación , Triazinas/uso terapéutico , Ácido Valproico/administración & dosificación , Ácido Valproico/uso terapéutico
10.
Cutis ; 48(3): 205-7, 1991 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-1935249

RESUMEN

Four patients with colorectal cancer treated with tegafur (a fluoropyrimidine structurally similar to 5-fluorouracil) noted a macular, spotted hyperpigmentation limited to the palms, soles, nails, and glans penis. Histopathologic examination disclosed epidermal basal hyperpigmentation with a lentiginous pattern. Mucocutaneous lesions resolved spontaneously two months after treatment was discontinued. This peculiar phenomenon seems to represent a previously unreported side effect of this cytotoxic drug.


Asunto(s)
Trastornos de la Pigmentación/inducido químicamente , Tegafur/efectos adversos , Anciano , Femenino , Dermatosis del Pie/inducido químicamente , Dermatosis del Pie/patología , Dermatosis de la Mano/inducido químicamente , Dermatosis de la Mano/patología , Humanos , Masculino , Persona de Mediana Edad , Trastornos de la Pigmentación/patología , Piel/patología
11.
Acta Derm Venereol ; 71(4): 334-6, 1991.
Artículo en Inglés | MEDLINE | ID: mdl-1681652

RESUMEN

The disseminated, miliarial type of lymphocytoma cutis (DMLC) is a clinicopathologic subtype of lymphocytoma, characterized by multiple, 1-2 mm translucent asymptomatic papules located in the exposed areas of the head and neck. DMLC represents a multifocal hyperplasia of B-lymphocytes with follicular differentiation and formation of follicular germinal centres. The evolution of the disease is characteristic, with some of the lesions resolving and other progressing to nodules or pseudolymphomas. The disease has a chronic course, with complete resolution in one to several years.


Asunto(s)
Neoplasias de Cabeza y Cuello/patología , Leucemia Linfocítica Crónica de Células B/patología , Neoplasias Cutáneas/patología , Neoplasias de las Glándulas Sudoríparas/patología , Anciano , Anciano de 80 o más Años , Humanos , Masculino , Remisión Espontánea
14.
J Dermatol Surg Oncol ; 13(10): 1089-92, 1987 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-3655079

RESUMEN

Verrucous hemangioma is an infrequent variety of deep-seated capillary or cavernous hemangioma with reactive epidermal hyperplasia and a superficial component indistinguishable from those of angiokeratoma. Four cases of verrucous hemangioma are reported herein. Verrucous hemangiomas are usually congenital lesions which do not resolve spontaneously and have a tendency to recur after excision if margins are inadequate. Careful histopathologic and clinical evaluation are required for an optimal therapeutic approach.


Asunto(s)
Hemangioma/patología , Neoplasias Cutáneas/patología , Adulto , Anciano , Diagnóstico Diferencial , Femenino , Hemangioma/cirugía , Humanos , Masculino , Neoplasias Cutáneas/cirugía
15.
Int J Dermatol ; 25(3): 191-3, 1986 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-2939033

RESUMEN

Excessive, pseudotumoral granulation tissue proliferations appeared in three patients receiving isotretinoin for nodulocystic acne. A review of the literature disclosed few reports of this unusual adverse reaction. Two clinical patterns have been reported; one in a periungual location and the other occurring in the sites of acne lesions during isotretinoin therapy. Loose edematous connective tissue with small vessels and chronic inflammatory infiltrate were the histologic findings in all three cases.


Asunto(s)
Tejido de Granulación/efectos de los fármacos , Tretinoina/efectos adversos , Acné Vulgar/tratamiento farmacológico , Adolescente , Adulto , Tejido Conectivo/patología , Tejido de Granulación/patología , Humanos , Isomerismo , Isotretinoína , Masculino , Piel/patología , Tretinoina/uso terapéutico
16.
Med Cutan Ibero Lat Am ; 14(6): 429-31, 1986.
Artículo en Español | MEDLINE | ID: mdl-3550320

RESUMEN

Fibroma of the tendon sheath (FTS) is a rare benign soft tissue tumor. Its location and clinical findings may be similar to the giant cell tumor of tendon sheath or to infantile digital fibromatosis. Accurate diagnosis of FTS depends on microscopic examination of the excised tumor. The present report deals with two cases.


Asunto(s)
Fibroma/patología , Neoplasias de los Tejidos Blandos/patología , Tendones/patología , Adulto , Diagnóstico Diferencial , Femenino , Fibroma/diagnóstico , Dedos , Humanos , Persona de Mediana Edad , Neoplasias Cutáneas/diagnóstico , Neoplasias de los Tejidos Blandos/diagnóstico , Pulgar
18.
J Am Acad Dermatol ; 12(5 Pt 2): 961-4, 1985 May.
Artículo en Inglés | MEDLINE | ID: mdl-3158680

RESUMEN

POEMS syndrome is an unusual plasma cell dyscrasia with multisystemic manifestations featuring polyneuropathy, organomegaly, endocrinopathy, M protein and constant skin involvement. We have seen a 58-year-old white man presenting with generalized eruptive angiomas as a rare skin manifestation of this syndrome. We review the literature and discuss the pathogenesis of vascular proliferation in this unusual entity.


Asunto(s)
Cardiomegalia/complicaciones , Enfermedades del Sistema Endocrino/complicaciones , Glicoproteínas/biosíntesis , Hemangioma/etiología , Hepatomegalia/complicaciones , Enfermedades Renales/complicaciones , Enfermedades del Sistema Nervioso/complicaciones , Enfermedades de la Piel/complicaciones , Neoplasias Cutáneas/etiología , Humanos , Masculino , Persona de Mediana Edad , Paraproteinemias/complicaciones , Síndrome
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