RESUMEN
A newborn presented with extensive rounded and velvety epidermal nevus (RAVEN) with a genetic study of the cutaneous lesions revealing a heterozygous mutation in FGFR2 (p.Cys382Arg). By 2 years of age, the patient developed hair heterochromia and autism spectrum disorder. Although RAVEN was initially associated with fibroblast growth factor 3 (FGFR3) mutations, three cases of RAVEN have been identified with mutations in FGFR2 (p.Ser252Trp) and one case of linear keratinocytic epidermal nevi has been identified with the same mutation as the mutation identified in our patient. This strongly supports the pathogenic role of these mutations.
Asunto(s)
Trastorno del Espectro Autista , Trastorno Autístico , Cuervos , Nevo Sebáceo de Jadassohn , Nevo , Recién Nacido , Animales , Humanos , Nevo/patología , Mutación , Cabello/patología , Receptor Tipo 2 de Factor de Crecimiento de Fibroblastos/genéticaRESUMEN
We present a 65-year-old woman with a 10-year history of cutaneous sarcoidosis, refractory to multiple immunosuppressants and biologics. After 10 sessions of conventional photodynamic therapy (PDT) and 6 sessions of daylight PDT, we achieved a satisfactory local control of the lesion, reducing the thickness and orange coloration of the plaque and preventing superinfections, although systemic treatment had to be maintained. PDT could be a useful therapeutic option for cutaneous sarcoidosis.
Asunto(s)
Queratosis Actínica , Fotoquimioterapia , Sarcoidosis , Anciano , Ácido Aminolevulínico/uso terapéutico , Femenino , Humanos , Queratosis Actínica/tratamiento farmacológico , Fotoquimioterapia/métodos , Fármacos Fotosensibilizantes/uso terapéutico , Sarcoidosis/tratamiento farmacológico , Resultado del TratamientoRESUMEN
Tattoo complications are an increasing reason for dermatological consultation in recent years, becoming a therapeutic challenge in some cases. We present a case of a suppurative granulomatous reaction in a tattoo resistant to oral antibiotic and topical corticosteroid treatment that resolved after four sessions of photodynamic therapy (PDT) with methyl aminolevulinate, possibly due to its anti-inflammatory and antimicrobial action, with an excellent aesthetic result. We suggest that the clinical utility of PDT may be expanded to treatment of tattoo complications, as well as in cutaneous infections of unknown microorganisms resistant to antibiotics.
