Dermatosis Inmunoglobulina A lineal dishidrosiforme / Dyshidrosiform Linear Immunoglobulin A Dermatosis

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Pioderma granulomatoso superficial. Presentación de 2 casos tratados con tacrolimus tópico / Superficial Granulomatous Pyoderma. Report of 2 Cases Treated With Topical Tacrolimus

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Fenómeno isotópico de Wolf: serie de 9 casos / Wolf’s Isotopic Response: A Series of 9 Cases

Introducción: El fenómeno isotópico de Wolf se define como la aparición de una enfermedad cutánea nueva en la misma localización donde previamente ha acontecido otra, ya curada, y con la que no guarda ninguna relación. En la mayoría de los casos, la primera dermatosis es un herpes zóster (HZ). Posteriormente, en esta localización pueden desarrollarse diversos procesos dermatológicos, fundamentalmente reacciones granulomatosas y liquenoides, infiltraciones específicas de enfermedades hematológicas, tumores cutáneos o infecciones. La patogenia de estas reacciones cutáneas es desconocida. Se ha sugerido que la infección viral pudiera alterar la inmunidad cutánea local, favoreciendo una hiperreactividad que determinaría el desarrollo de procesos inflamatorios, o una inmunosupresión local, que condicionaría la aparición de infiltraciones tumorales o infecciones. Material y métodos: Estudio retrospectivo de 9 pacientes diagnosticados de fenómeno isotópico de Wolf en el Servicio de Dermatología del Hospital Donostia. Cinco pacientes tenían una leucemia linfática crónica-B (LLC-B), 2 un linfoma no Hodgkin y una un carcinoma de ovario. Resultados: La dermatosis primaria en 7 casos fue un HZ, en los otros 2 una varicela y un herpes simple. Respecto a las dermatosis secundarias se diagnosticaron 4 casos de dermatitis granulomatosa, 2 de dermatitis liquenoide, 2 de infiltración específica por LLC-B y uno de infiltración por un linfoma no Hodgkin sistémico. En este último caso las lesiones cutáneas fueron el primer signo del linfoma. Conclusiones: Destacamos la necesidad de biopsiar este tipo de lesiones para descartar infiltraciones específicas tumorales, ya que en nuestra casuística fueron más frecuentes de lo esperado (AU)

Introduction: The term Wolf s isotopic response refers to the appearance of a new skin disease at the site of an already healed, unrelated disease. In most cases, the initial disease is herpes zoster. Different diseases may subsequently develop on the same site. The most common isotopic responses are granulomatous and lichenoid reactions, infiltrations of hematologic diseases, skin tumors, and infections. The pathogenesis of these skin reactions is unknown. It has been suggested that viral infection may alter local skin immunity; this would favor hyperreactivity, leading to inflammatory processes, or local immunosuppression, leading to tumor infiltrations or infections. Materials and methods: We performed a retrospective study of 9 patients diagnosed with Wolf’s isotopic response in the dermatology department of Hospital Donostia in San Sebastian, Spain. Five patients had B-cell chronic lymphocytic leukemia, 2 had a non-Hodgkin lymphoma, and 1had ovarian carcinoma. Results: The initial disease was herpes zoster in 7 cases, and chickenpox and herpes simplex in the other 2 cases. The second disease was granulomatous dermatitis in 4 cases, lichenoid dermatitis in 2 cases, infiltration by B-cell chronic lymphatic leukemia in 2 cases, and infiltration by systemic non-Hodgkin lymphoma in 1 case. In the last case, the skin lesions were the first sign of the lymphoma. Conclusions: We highlight the need to biopsy these second lesions in order to rule out tumor infiltrations, which were more frequent than expected in our series (AU)

Wolf's isotopic response: a series of 9 cases.

INTRODUCTION: The term Wolf's isotopic response refers to the appearance of a new skin disease at the site of an already healed, unrelated disease. In most cases, the initial disease is herpes zoster. Different diseases may subsequently develop on the same site. The most common isotopic responses are granulomatous and lichenoid reactions, infiltrations of hematologic diseases, skin tumors, and infections. The pathogenesis of these skin reactions is unknown. It has been suggested that viral infection may alter local skin immunity; this would favor hyperreactivity, leading to inflammatory processes, or local immunosuppression, leading to tumor infiltrations or infections. MATERIALS AND METHODS: We performed a retrospective study of 9 patients diagnosed with Wolf's isotopic response in the dermatology department of Hospital Donostia in San Sebastian, Spain. Five patients had B-cell chronic lymphocytic leukemia, 2 had a non-Hodgkin lymphoma, and 1 had ovarian carcinoma. RESULTS: The initial disease was herpes zoster in 7 cases, and chickenpox and herpes simplex in the other 2 cases. The second disease was granulomatous dermatitis in 4 cases, lichenoid dermatitis in 2 cases, infiltration by B-cell chronic lymphatic leukemia in 2 cases, and infiltration by systemic non-Hodgkin lymphoma in 1 case. In the last case, the skin lesions were the first sign of the lymphoma. CONCLUSIONS: We highlight the need to biopsy these second lesions in order to rule out tumor infiltrations, which were more frequent than expected in our series.

Malformación adenomatoidea quística pulmonar: actualización de la entidad a propósito de cinco casos / Cystic adenomatoid malformations of the lung: presentation of 5 cases and review

Presentamos una serie de cinco casos de malformación adenomatoideaquística pulmonar, recogidos en el período 1994-2006. Es una entidad poco frecuente (aproximadamente 400 casos publicados)que tiene características morfológicas de inmadurez pulmonar. Todos los pacientes estudiados fueron tratados quirúrgicamente en nuestro centro. Revisamos la evolución del proceso, los hallazgos histológicos, la clasificación actual de la entidad y los aspectos más novedosos del diagnóstico y tratamiento quirúrgico prenatal. Tres de nuestros pacientes eran varones, recién nacidos a término, y los otros dos pacientes eran niñas, de 3 y 9 años. En todos ellos los hallazgos radiológicos mostraban imágenes quísticas limitadas a un lóbulo, ocupados por aire o por líquido. Tras la lobectomía en el estudio histológico, cuatro de ellas fueron clasificadas como tipo 2 de la clasificación de Stoker y una (la paciente de más edad) como tipo 1 (AU)

We describe five cases of cystic adenomatoid malformations of the lung collected from our files from 1994 to 2006. It is an unusual malformation and has features of immaturity with less than 400cases previously published. All patients were surgically treated in our institution. We review the clinical outcome, microscopic findings, current classification schemes and prenatal surgical treatment. Our study includes 3 new-born males and two girls, 3 and 9 years old. All of them radiographically showed air or fluid filled cystic masses involving a single lobe. After lobectomy, four lung specimens were classified as Stoker type 2 lesions and the older one as type 1 (AU)

[Carcinosarcoma with chondromatous differentiation of the bladder]. / Carcinosarcoma con diferenciación condromatoide de vejiga.

We report a case of carcinosarcoma whose most striking feature was its markedly chondroid elements that initially prompted us to suspect a chondrosarcoma. The clinical features and treatment of this rare tumor type are briefly discussed.

[Adenomatoid tumor of the albuginea testis]. / Tumor adenomatoide de albugínea testicular.

We present a rare case of adenomatoid tumour situated in the testicular albuginea. We comment on its treatment, which we are of the opinion should be conservative.