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1.
Sci Rep ; 12(1): 4289, 2022 03 11.
Artículo en Inglés | MEDLINE | ID: mdl-35277570

RESUMEN

During the Last Glacial Maximum, a small band of Siberians entered the Beringian corridor, where they persisted, isolated from gene flow, for several thousand years before expansion into the Americas. The ecological features of the Beringian environment, coupled with an extended period of isolation at small population size, would have provided evolutionary opportunity for novel genetic variation to arise as both rare standing variants and new mutations were driven to high frequency through both neutral and directed processes. Here we perform a full genome investigation of Native American populations in the Thousand Genomes Project Phase 3 to identify unique high frequency alleles that can be dated to an origin in Beringia. Our analyses demonstrate that descendant populations of Native Americans harbor 20,424 such variants, which is on a scale comparable only to Africa and the Out of Africa bottleneck. This is consistent with simulations of a serial founder effects model. Tests for selection reveal that some of these Beringian variants were likely driven to high frequency by adaptive processes, and bioinformatic analyses suggest possible phenotypic pathways that were under selection during the Beringian Isolation period. Specifically, pathways related to cardiac processes and melanocyte function appear to be enriched for selected Beringian variants.


Asunto(s)
Evolución Biológica , Flujo Génico , Alelos , Efecto Fundador , Variación Genética , Humanos , Indio Americano o Nativo de Alaska
2.
Sci Rep ; 12(1): 1059, 2022 01 20.
Artículo en Inglés | MEDLINE | ID: mdl-35058485

RESUMEN

Patterns of diversity in pathogen genomes provide a window into the spatiotemporal spread of disease. In this study, we tested the hypothesis that Schistosoma mansoni parasites form genetic clusters that coincide with the communities of their human hosts. We also looked for genetic clustering of parasites at the sub-community level. Our data consists of 14 microsatellite DNA markers, typed from pooled DNA samples from [Formula: see text] infected individuals living in three Brazilian communities. We found a one-to-one correspondence between genetic clusters found by K-means cluster analysis and communities when [Formula: see text]. These clusters are also easily identified in a neighbor-joining tree and principal coordinates plots. K-means analysis with [Formula: see text] also reveals genetic clusters of parasites at the sub-community level. These sub-clusters also appear on the neighbor-joining tree and principal coordinates plots. A surprising finding is a genetic relationship between subgroups in widely separated human communities. This connection suggests the existence of common transmission sites that have wide influence. In summary, the genetic structure of S. mansoni in Brazil juxtaposes local isolation that is occasionally broken by long-range migration. Permanent eradication of schistosomes will require both local efforts and the identification of regional infection reservoirs.


Asunto(s)
Genética de Población , Schistosoma mansoni/genética , Esquistosomiasis mansoni/parasitología , Animales , Brasil , Análisis por Conglomerados , Interacciones Huésped-Parásitos/genética , Humanos , Repeticiones de Microsatélite , Schistosoma mansoni/aislamiento & purificación , Esquistosomiasis mansoni/transmisión
3.
Int J Parasitol ; 51(12): 1007-1014, 2021 11.
Artículo en Inglés | MEDLINE | ID: mdl-34022195

RESUMEN

All Schistosoma mansoni tri- and tetranucleotide repeat microsatellites published as of December 2018 were identified. All 52 were evaluated for autosomal location, strength of amplification, scorability and behavior as single-copy loci by polyacrylamide and capillary gel electrophoresis. Of these, 27 were unique, autosomal, polymorphic, easily scored and single copy as assessed on pooled adult worm DNA from two different continental origins and adult worm clones. These microsatellites were distributed across all seven autosomal chromosomes. On laboratory strains their heterozygosity ranged from 0.22 to 0.77. Individual markers had 5-13 alleles, allelic richness of 2-10 and an effective allele number of 1.3-8.14. Those infected by Schistosoma mansoni carry many genetically distinct, sexually reproducing parasites, therefore, for an individual infection the complete allele frequency profile of their progeny consists of a pool of DNA from multiple diploid eggs. Using a set of 25 microsatellites, we calculated allele frequency profiles of eggs in fecal samples from people in two Brazilian communities separated by 6 km: Jenipapo (n = 80) and Volta do Rio (n = 38). There were no a priori characteristics that could predict the performance of markers in natural infections based on their performance with laboratory strains. Increasing marker number did not change accuracy for differentiation and diversity but did improve precision. Our data suggest that using a random set of 10-20 microsatellites appears to result in values that exhibit low standard deviations for diversity and differentiation indices. All identified microsatellites as well as PCR conditions, allele size, primer sequences and references for all tri- and tetramer microsatellites markers presented in this work are available at: https://sites.google.com/case.edu/cwru-and-fiocruz-wdrc/home.


Asunto(s)
Variación Genética , Schistosoma mansoni , Animales , Frecuencia de los Genes , Genética de Población , Humanos , Repeticiones de Microsatélite , Schistosoma mansoni/genética
4.
Am J Phys Anthropol ; 165(2): 256-268, 2018 02.
Artículo en Inglés | MEDLINE | ID: mdl-29082507

RESUMEN

OBJECTIVE: We present a model that partitions Nei's minimum genetic distance between admixed populations into components of admixture and genetic drift. We applied this model to 17 admixed populations in the Americas to examine how admixture and drift have contributed to the patterns of genetic diversity. MATERIALS AND METHODS: We analyzed 618 short tandem repeat loci in 949 individuals from 49 population samples. Thirty-two samples serve as proxies for continental ancestors. Seventeen samples represent admixed populations: (4) African-American and (13) Latin American. We partition genetic distance, and then calculate fixation indices and principal coordinates to interpret our results. A computer simulation confirms that our method correctly estimates drift and admixture components of genetic distance when the assumptions of the model are met. RESULTS: The partition of genetic distance shows that both admixture and genetic drift contribute to patterns of genetic diversity. The admixture component of genetic distance provides evidence for two distinct axes of continental ancestry. However, the genetic distances show that ancestry contributes to only one axis of genetic differentiation. The genetic distances among the 13 Latin American populations in this analysis show contributions from both differences in ancestry and differences in genetic drift. By contrast, the genetic distances among the four African American populations in this analysis owe mostly to genetic drift because these groups have similar fractions of European and African ancestry. CONCLUSION: The genetic structure of admixed populations in the Americas reflects more than admixture. We show that the history of serial founder effects constrains the impact of admixture on allele frequencies to a single dimension. Genetic drift in the admixed populations imposed a new level of genetic structure onto that created by admixture.


Asunto(s)
Negro o Afroamericano/genética , Flujo Genético , Variación Genética/genética , Hispánicos o Latinos/genética , Simulación por Computador , Frecuencia de los Genes/genética , Genética de Población , Humanos , Repeticiones de Microsatélite/genética
5.
Am J Phys Anthropol ; 160(4): 561-9, 2016 08.
Artículo en Inglés | MEDLINE | ID: mdl-26619959

RESUMEN

OBJECTIVES: Studies of the apportionment of human genetic diversity have found that local populations harbor nearly as much diversity as the species as a whole. These studies have been a valuable cornerstone in rejecting race as a biological framework in anthropology. The current study presents new analyses that use updated statistical methods based on bifurcating trees to assess the structure of human genetic diversity and its implications for the existence of canonical biological races. MATERIALS AND METHODS: We examine patterns of both goodness-of-fit and lack-of-fit of two bifurcating trees to patterns of diversity determined from autosomal short tandem repeat genotypes in 1,037 people representing 52 populations with worldwide distribution. RESULTS: From goodness-of-fit, we infer a root for the tree within Africa, and we recapitulate a pattern of decreasing genetic diversity with increasing geographic distance from Africa. From lack-of-fit, we present tentative evidence for admixture events with archaic hominins. We do not find evidence that long-range migration or local gene flow have contributed appreciably to the lack of fit at a global scale. CONCLUSION: This is the first study to find a root for a tree of human populations without comparison to a nonhuman out-group, and it is one of the first studies to identify a signature of admixture with archaic hominins without reference to ancient DNA. Our findings complement previous studies of the apportionment of human diversity and provide a more solid evolutionary foundation for the rejection of biological race. Am J Phys Anthropol 160:561-569, 2016. © 2015 Wiley Periodicals, Inc.


Asunto(s)
Antropología Física/métodos , Variación Genética/genética , Genética de Población , Modelos Estadísticos , Flujo Génico/genética , Humanos , Repeticiones de Microsatélite , Grupos Raciales/genética , Grupos Raciales/estadística & datos numéricos
6.
Nucleic Acids Res ; 41(Database issue): D56-63, 2013 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-23193274

RESUMEN

The Encyclopedia of DNA Elements (ENCODE), http://encodeproject.org, has completed its fifth year of scientific collaboration to create a comprehensive catalog of functional elements in the human genome, and its third year of investigations in the mouse genome. Since the last report in this journal, the ENCODE human data repertoire has grown by 898 new experiments (totaling 2886), accompanied by a major integrative analysis. In the mouse genome, results from 404 new experiments became available this year, increasing the total to 583, collected during the course of the project. The University of California, Santa Cruz, makes this data available on the public Genome Browser http://genome.ucsc.edu for visual browsing and data mining. Download of raw and processed data files are all supported. The ENCODE portal provides specialized tools and information about the ENCODE data sets.


Asunto(s)
Bases de Datos Genéticas , Genoma Humano , Genómica , Animales , Humanos , Internet , Ratones , Programas Informáticos
7.
Nucleic Acids Res ; 40(Database issue): D912-7, 2012 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-22075998

RESUMEN

The Encyclopedia of DNA Elements (ENCODE) Consortium is entering its 5th year of production-level effort generating high-quality whole-genome functional annotations of the human genome. The past year has brought the ENCODE compendium of functional elements to critical mass, with a diverse set of 27 biochemical assays now covering 200 distinct human cell types. Within the mouse genome, which has been under study by ENCODE groups for the past 2 years, 37 cell types have been assayed. Over 2000 individual experiments have been completed and submitted to the Data Coordination Center for public use. UCSC makes this data available on the quality-reviewed public Genome Browser (http://genome.ucsc.edu) and on an early-access Preview Browser (http://genome-preview.ucsc.edu). Visual browsing, data mining and download of raw and processed data files are all supported. An ENCODE portal (http://encodeproject.org) provides specialized tools and information about the ENCODE data sets.


Asunto(s)
Bases de Datos de Ácidos Nucleicos , Genoma Humano , Genoma , Ratones/genética , Animales , Humanos , Internet , Anotación de Secuencia Molecular , Programas Informáticos
9.
Ann Hum Genet ; 75(4): 508-15, 2011 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-21668907

RESUMEN

To test for and characterize heterogeneity in ancestral contributions to individuals among a population of Mexican American (MA) and non-Hispanic white (NHW) stroke/transient ischemic attack (TIA) cases, data from a community-based stroke surveillance study in south Texas were used. Strokes/TIA cases were identified (2004-2006) with a random sample asked to provide blood. Race-ethnicity was self-reported. Thirty-three ancestry informative markers were genotyped and individual genetic admixture estimated using maximum likelihood methods. Three hypotheses were tested for each MA using likelihood ratio tests: (1) H(0) : µi = 0 (100% Native American), (2) H(0) : µi = 1.00 (100% European), (3) H(0) : µi = 0.59 (average European). Among 154 self-identified MAs, estimated European ancestry varied from 0.26 to 0.98, with an average of 0.59 (SE = 0.014). We rejected hypothesis 1 for every MA and rejected hypothesis 2 for all but two MAs. We rejected hypothesis 3 for 40 MAs (20 < 59%, 20 > 59%). Among 84 self-identified NHWs, the estimated fraction of European ancestry ranged from 0.83 to 1.0, with an average of 0.97 (SE = 0.014). Self-identified MAs, and to a lesser extent NHWs, from an established bi-ethnic community were heterogeneous with respect to genetic admixture. Researchers should not use simple race-ethnic categories as proxies for homogeneous genetic populations when conducting gene mapping and disease association studies in multi-ethnic populations.


Asunto(s)
Ataque Isquémico Transitorio/etnología , Ataque Isquémico Transitorio/genética , Americanos Mexicanos/genética , Accidente Cerebrovascular/etnología , Accidente Cerebrovascular/genética , Población Blanca , Anciano , Femenino , Frecuencia de los Genes , Marcadores Genéticos , Humanos , Indígenas Norteamericanos , Masculino , Persona de Mediana Edad , Polimorfismo de Nucleótido Simple , Factores de Riesgo
10.
Am J Hum Genet ; 86(5): 661-73, 2010 May 14.
Artículo en Inglés | MEDLINE | ID: mdl-20466090

RESUMEN

Increasing public interest in direct-to-consumer (DTC) genetic ancestry testing has been accompanied by growing concern about issues ranging from the personal and societal implications of the testing to the scientific validity of ancestry inference. The very concept of "ancestry" is subject to misunderstanding in both the general and scientific communities. What do we mean by ancestry? How exactly is ancestry measured? How far back can such ancestry be defined and by which genetic tools? How do we validate inferences about ancestry in genetic research? What are the data that demonstrate our ability to do this correctly? What can we say and what can we not say from our research findings and the test results that we generate? This white paper from the American Society of Human Genetics (ASHG) Ancestry and Ancestry Testing Task Force builds upon the 2008 ASHG Ancestry Testing Summary Statement in providing a more in-depth analysis of key scientific and non-scientific aspects of genetic ancestry inference in academia and industry. It culminates with recommendations for advancing the current debate and facilitating the development of scientifically based, ethically sound, and socially attentive guidelines concerning the use of these continually evolving technologies.


Asunto(s)
Genes , Investigación Genética/ética , Pacientes/psicología , Población Blanca/genética , Pruebas Genéticas/normas , Humanos
11.
Genome Res ; 19(5): 703-10, 2009 May.
Artículo en Inglés | MEDLINE | ID: mdl-19411595

RESUMEN

There is widespread interest in characterizing the organization of human genetic variation around the world from a population perspective. Related to this are attempts to describe the pattern of genetic variation in the human species generally, including "recreational" genomics, the genome-based estimation of the ancestry of individuals. These approaches rest on subtle concepts of variation, time, and ancestry that are perhaps not widely appreciated. They share the idea that there are, or were, discrete panmictic human populations such that every person is either a member of such a population or is an admixed descendant of them. Ancestry fraction estimation is biased by assumptions about past and present human population structure, as when we trace ancestry to hypothetical unmixed ancestral populations, or assign an individual's ancestry to continental populations that are indistinguishable from classical "races." Attempts to identify even individuals' local subpopulations are less precise than most (geneticists included) expect, because that is usually based on a small portion of a person's ancestry, relative to the much larger pool of comparably related ancestors. It is easier to show that two people have some relationship than to show who or where the actual ancestor was. There is an important distinction between individuals' demographic ancestry and the ancestry of their genes. Despite superficial appearances, these interpretations of genetic data are often based on typological rather than Darwinian thinking, raising important issues about the questions that are actually being asked.


Asunto(s)
Variación Genética , Genética de Población , Evolución Biológica , Etnicidad/genética , Especiación Genética , Genoma Humano , Humanos , Desequilibrio de Ligamiento , Polimorfismo de Nucleótido Simple
12.
Brain Cogn ; 70(1): 145-53, 2009 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-19243871

RESUMEN

Relationships between parent and child executive functioning were examined, controlling for the critical potential confound of IQ, in a family study involving 434 children (130 girls and 304 boys) and 376 parents from 204 community recruited families at high risk for the development of substance use disorder. Structural equation modeling found evidence of separate executive functioning and intelligence (IQ) latent variables. Mother's and father's executive functioning were associated with child's executive functioning (beta = 0.34 for father-child and 0.51 for mother-child), independently of parental IQ, which as expected was associated with child's IQ (beta = 0.52 for father-child and 0.54 for mother-child). Familial correlations also showed a significant relationship of executive functioning between parents and offspring. These findings clarify that key elements of the executive functioning construct are reliably differentiable from IQ, and are transmitted in families. This work supports the utility of the construct of executive function in further study of the mechanisms and etiology of externalizing psychopathologies.


Asunto(s)
Cognición , Inteligencia , Procesos Mentales , Relaciones Padres-Hijo , Adolescente , Adulto , Alcoholismo , Niño , Femenino , Predisposición Genética a la Enfermedad , Humanos , Pruebas de Inteligencia , Funciones de Verosimilitud , Masculino , Modelos Psicológicos , Pruebas Neuropsicológicas , Análisis de Regresión , Factores de Riesgo
13.
Am J Phys Anthropol ; 139(1): 35-46, 2009 May.
Artículo en Inglés | MEDLINE | ID: mdl-19226641

RESUMEN

Several recent studies have argued that human genetic variation conforms to a model of isolation by distance, whereas others see a predominant role for long-range migrations and bottlenecks. It is unclear whether either of these views fully describes the global pattern of human genetic variation. In this article, we use a coalescent-based simulation approach to compare the pattern of neutral genetic variation predicted by these views to the observed pattern estimated from neutral autosomal microsatellites assayed in 1,032 individuals from 53 globally-distributed populations. We find that neither view predicts every aspect of the observed pattern of variation on its own, but that a combination of the two does. Specifically, we demonstrate that the observed pattern of global gene identity variation is consistent with a history of serial population fissions, bottlenecks and long-range migrations associated with the peopling of major geographic regions, and gene flow between local populations. This history has produced a nested pattern of genetic structure that is inconsistent with the existence of independently evolving biological races. We consider the implications of our findings for methods that apportion variation into within- and between-group components and for medical genetics.


Asunto(s)
Emigración e Inmigración , Efecto Fundador , Genes/genética , Variación Genética , Genética de Población , Modelos Genéticos , Grupos Raciales/genética , Simulación por Computador , Humanos , Repeticiones de Microsatélite/genética
14.
Am J Phys Anthropol ; 139(1): 23-34, 2009 May.
Artículo en Inglés | MEDLINE | ID: mdl-19226648

RESUMEN

Interest in genetic diversity within and between human populations as a way to answer questions about race has intensified in light of recent advances in genome technology. The purpose of this article is to apply a method of generalized hierarchical modeling to two DNA data sets. The first data set consists of a small sample of individuals (n = 32 total, from eight populations) who have been fully resequenced for 63 loci that encode a total of 38,534 base pairs. The second data set consists of a large sample of individuals (n = 928 total, from 46 populations) who have been genotyped at 580 loci that encode short tandem repeats. The results are clear and somewhat surprising. We see that populations differ in the amount of diversity that they harbor. The pattern of DNA diversity is one of nested subsets, such that the diversity in non-Sub-Saharan African populations is essentially a subset of the diversity found in Sub-Saharan African populations. The actual pattern of DNA diversity creates some unsettling problems for using race as meaningful genetic categories. For example, the pattern of DNA diversity implies that some populations belong to more than one race (e.g., Europeans), whereas other populations do not belong to any race at all (e.g., Sub-Saharan Africans). As Frank Livingstone noted long ago, the Linnean classification system cannot accommodate this pattern because within the system a population cannot belong to more than one named group within a taxonomic level.


Asunto(s)
ADN/genética , Variación Genética , Genética de Población , Modelos Genéticos , Grupos Raciales/clasificación , Grupos Raciales/genética , Secuencia de Bases , Etnicidad/genética , Humanos , Datos de Secuencia Molecular , Análisis de Secuencia de ADN
17.
Neuroepidemiology ; 31(1): 33-8, 2008.
Artículo en Inglés | MEDLINE | ID: mdl-18535398

RESUMEN

BACKGROUND: Mexican Americans (MAs) have an increased risk of stroke compared with non-Hispanic whites (NHWs), especially at younger ages. Little is known regarding patterns of familial aggregation of stroke and whether familial risk assessment might prove a potentially useful tool in assessing stroke risk in this population. This study's objective was to estimate the sibling recurrence risk ratio (lambda(s)) for stroke and to compare this ratio between MAs and NHWs. METHODS: Stroke and transient ischemic attack (TIA) cases (n = 181) between the ages of 45 and 64 years were identified by a population-based stroke study in a biethnic Texas community. lambda(s) was calculated overall and by ethnicity. RESULTS: Siblings of ischemic stroke/TIA cases had a doubling in stroke risk compared to what would be expected based on national stroke prevalence estimates (lambda(s) = 1.92; 95% CI: 1.39-2.61). lambda(s) was 2.0 (95% CI: 1.39-2.81) among MA stroke/TIA cases and 1.66 (95% CI: 0.82-3.10) among NHW stroke/TIA cases. CONCLUSION: The sibling recurrence risk for stroke was elevated in MA stroke/TIA cases suggesting that further ischemic stroke genetic studies across ethnicities may be warranted. In addition, a positive family history could prove a useful factor in the clinical setting for identifying MAs at increased stroke risk.


Asunto(s)
Etnicidad/etnología , Americanos Mexicanos/etnología , Características de la Residencia , Hermanos/etnología , Accidente Cerebrovascular/etnología , Etnicidad/genética , Femenino , Humanos , Masculino , Persona de Mediana Edad , Proyectos Piloto , Vigilancia de la Población/métodos , Factores de Riesgo , Accidente Cerebrovascular/genética , Población Blanca
18.
Mol Biol Evol ; 25(3): 478-86, 2008 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-18222947

RESUMEN

Genetic diversity in Native South Americans forms a complex pattern at both the continental and local levels. In comparing the West to the East, there is more variation within groups and smaller genetic distances between groups. From this pattern, researchers have proposed that there is more variation in the West and that a larger, more genetically diverse, founding population entered the West than the East. Here, we question this characterization of South American genetic variation and its interpretation. Our concern arises because others have inferred regional variation from the mean variation within local populations without taking into account the variation among local populations within the same region. This failure produces a biased view of the actual variation in the East. In this study, we analyze the mitochondrial DNA sequence between positions 16040 and 16322 of the Cambridge reference sequence. Our sample represents a total of 886 people from 27 indigenous populations from South (22), Central (3), and North America (2). The basic unit of our analyses is nucleotide identity by descent, which is easily modeled and proportional to nucleotide diversity. We use a forward modeling strategy to fit a series of nested models to identity by descent within and between all pairs of local populations. This method provides estimates of identity by descent at different levels of population hierarchy without assuming homogeneity within populations, regions, or continents. Our main discovery is that Eastern South America harbors more genetic variation than has been recognized. We find no evidence that there is increased identity by descent in the East relative to the total for South America. By contrast, we discovered that populations in the Western region, as a group, harbor more identity by descent than has been previously recognized, despite the fact that average identity by descent within groups is lower. In this light, there is no need to postulate separate founding populations for the East and the West because the variability in the East could serve as a source for the Western gene pools.


Asunto(s)
ADN Mitocondrial/genética , Variación Genética , Indígenas Sudamericanos/genética , Filogenia , Genética de Población , Humanos , Modelos Genéticos , América del Sur
19.
Am J Med Genet B Neuropsychiatr Genet ; 147B(1): 86-93, 2008 Jan 05.
Artículo en Inglés | MEDLINE | ID: mdl-17722024

RESUMEN

Recent efforts have focused on the challenges of finding alleles that contribute to health-related phenotypes in genome-wide association studies. However, in candidate gene studies, where the genomic region of interest is small and recombination is limited, factors that affect the ability to detect disease-susceptibility alleles remain poorly understood. In particular, it is unclear how varying the number of markers on a haplotype, the type of marker (e.g., single nucleotide polymorphism (SNP), short tandem repeat (STR)), including the causative site (cs) as a genetic marker, or population demographics influences the power to detect a candidate gene. We evaluated the power of association tests using coalescent-modeled computer simulations. Results show that an effective number of markers on a haplotype is dependent on whether the cs is included as a marker. When the analyses include the cs, highest power is achieved with a single-marker association test. However, when the cs is excluded from analyses, the addition of more nonfunctional SNPs on the haplotype increases power to a certain point under most scenarios. We find a rapidly expanding population always has lower power compared to a population of constant size; although utilizing markers with a frequency of at least 5% improves the chance of detecting an association. Comparing the mutational properties of a nonfunctional SNP versus an STR, multi-allelic STRs provide more or comparable power than a bi-allelic SNP unless SNP frequencies are constrained to 10% or more. Similarly, including an STR with SNPs on a haplotype improves power unless SNP frequencies are 5% or more.


Asunto(s)
Predisposición Genética a la Enfermedad , Repeticiones de Microsatélite , Polimorfismo de Nucleótido Simple , Simulación por Computador , Ligamiento Genético , Marcadores Genéticos , Haplotipos , Humanos , Desequilibrio de Ligamiento , Fenotipo
20.
Nicotine Tob Res ; 9(8): 883-901, 2007 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-17654301

RESUMEN

A conference on the conduct of genomic research on complex behaviors was convened at the University of Michigan to demystify genetic research by describing the tools and methodologies for identifying genes and to assess the feasibility of conducting genomic research on smoking, a complex behavior with major public health import. These proceedings are excerpts based on the presentations at the conference.


Asunto(s)
Investigación Genética , Modelos Genéticos , Fumar/genética , Tabaquismo/genética , Predisposición Genética a la Enfermedad , Conductas Relacionadas con la Salud , Humanos , Agencias Internacionales , Cooperación Internacional , Fenotipo , Cese del Hábito de Fumar/métodos
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