RESUMEN
BACKGROUND: Our understanding of swallowing disorders after laryngectomy remains limited. A literature search found that documentation of swallowing function in the laryngectomee population is lacking. Furthermore, no consensus exists regarding a suitable evaluation tool to assess swallowing function. While conventional questionnaires are time consuming, cost and time constraints make regular objective swallowing investigations impractical. OBJECTIVES: To develop a 2-question simplified dysphagia score (SDS) screening tool for routine documentation of swallowing function at post-laryngectomy follow-up visits, and to test this new tool against an established dysphagia measuring tool for laryngectomees. We also sought to identify risk factors for poor swallowing outcomes. METHODS: Cross-sectional surveys were used to compare results obtained from the validated swallowing outcomes after laryngectomy (SOAL) questionnaire and our novel SDS tool. The components of the SDS were guided by the experience and expertise of surgeons and speech therapists, as well as insights from patients and their families. Sixty laryngectomy patients (females, n=7; males, n=53) were enrolled in the study. All patients were >18 years of age. Each participant was asked to complete the SDS and the SOAL questionnaires. The results of each tool were compared using non-parametric tests, with multiple pairwise comparisons using Bonferroni tests. RESULTS: Both sets of results showed a linear relationship using the Kruskal-Wallis non-parametric analysis of variance (ANOVA) test. The SDS had a specificity of 96% (95% confidence interval (CI) 76 - 100%), a sensitivity of 81% (CI 64 - 91%), a positive predictive value of 97% (CI 81 - 100%) and a negative predictive value of 76% (CI 56 - 89%) against the SOAL scores. The SDS results yielded 7 false-negative and 1 false-positive result for dysphagia compared with the SOAL questionnaire. Outcomes of the secondary objectives did not reach statistical significance. CONCLUSIONS: The SDS is a 2-question, practical grading system that shows a statistically significant correlation with the recognised SOAL questionnaire, making it a useful alternative for everyday use, which provides outcome scores of direct practical value to patient and clinician. Prospective use of the SDS and higher patient numbers may allow a better understanding of dysphagia, its causes and risk factors.
Asunto(s)
Trastornos de Deglución/diagnóstico , Laringectomía , Tamizaje Masivo/métodos , Complicaciones Posoperatorias/diagnóstico , Adulto , Estudios Transversales , Femenino , Humanos , Masculino , Encuestas y CuestionariosRESUMEN
OBJECTIVE: To assess the effect on hearing of non-functioning ventilation tubes due to blockage during the first six months post-operatively, using UK national guidelines. METHOD: A prospective, observational study was conducted on 37 children who underwent bilateral ventilation tube insertion. Air and bone conduction thresholds were measured before and following surgery, and at one, three and six months post-operatively. Tube non-function was assessed by tympanometry supported by otoscopy. RESULTS: Post-operatively, an average of 21 per cent of ventilation tubes were non-functioning. Ears with non-functioning tubes had significantly (p = 0.0001) poorer mean air conduction thresholds than functioning tubes, with a magnitude of 6 dB HL. Ears with otorrhoea were most affected (15 per cent). At any one visit, the air-bone gap was closed to 10 dB or less in 76 per cent of ears. Non-functioning tubes reduced this to 56 per cent. Compared with tympanometry, otoscopy underdiagnosed tube non-function due to blockage by 22 per cent. CONCLUSION: Non-functioning of ventilation tubes occurs frequently and can be missed on otoscopy. Although it is associated with poorer air conduction thresholds, the magnitude of this difference is unlikely to warrant further intervention unless there is otorrhoea or recurrence of bilateral hearing impairment.
Asunto(s)
Enfermedades del Oído/cirugía , Pérdida Auditiva Bilateral/cirugía , Audición/fisiología , Ventilación del Oído Medio/métodos , Otitis Media con Derrame/cirugía , Pruebas de Impedancia Acústica/métodos , Adolescente , Umbral Auditivo/fisiología , Conducción Ósea/fisiología , Niño , Preescolar , Femenino , Pérdida Auditiva Bilateral/etiología , Humanos , Masculino , Ventilación del Oído Medio/estadística & datos numéricos , Otitis Media con Derrame/complicaciones , Otoscopía/métodos , Periodo Posoperatorio , Estudios Prospectivos , RecurrenciaRESUMEN
BACKGROUND: Wegener's granulomatosis is generally a chronic, indolent, inflammatory condition, treated with cytotoxics (cyclophosphamide) and corticosteroids. OBJECTIVE: This paper reports an unusual case of acute fulminant Wegener's granulomatosis that failed to respond to conventional treatment, but showed a dramatic response to rituximab, which is a relatively new form of treatment for resistant cases. METHOD: As well as describing the case (with photographic illustrations), the current paper provides a review of the literature, focusing on acute Wegener's granulomatosis and frequency of resistance to 'conventional' forms of treatment. There is also an evaluation of the evidence for the effectiveness of rituximab in resistant Wegener's granulomatosis. RESULTS: The patient responded remarkably well to rituximab and had no disease recurrence at 24 months' follow up. CONCLUSION: Clinicians should be aware of the acute fulminant form of Wegener's granulomatosis, as a delay in diagnosis and treatment may have fatal consequences. The paper also highlights the dramatic response to rituximab experienced by the patient.
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Anticuerpos Monoclonales de Origen Murino/uso terapéutico , Granulomatosis con Poliangitis/diagnóstico , Granulomatosis con Poliangitis/tratamiento farmacológico , Factores Inmunológicos/uso terapéutico , Enfermedad Aguda , Adulto , Ciclofosfamida/efectos adversos , Ciclofosfamida/uso terapéutico , Diagnóstico Diferencial , Humanos , Inmunosupresores/efectos adversos , Inmunosupresores/uso terapéutico , Masculino , RituximabRESUMEN
OBJECTIVE: Primary: to compare one-off administration of boric acid powder with courses of 1% acetic acid and ciprofloxacin eardrops in treating active chronic otitis media. Secondary: to evaluate the effectiveness of Quadriderm® cream in resistant active chronic otitis media; and to document side effects of these treatments, especially hearing loss. STUDY DESIGN: Randomised controlled trial. SETTING: Outpatient department of a tertiary ENT unit. PARTICIPANTS: Hundred and fifty-nine patients over 6 years old with active chronic mucosal (without cholesteatoma) otitis media randomised to receive one of the three primary agents. METHOD: All techniques employed were suitable for primary healthcare givers as well as specialists. After confirming eligibility, patients were randomly allocated to treatment. All ears underwent toilet with irrigation using clean water, a syringe and ambient light, with or without dry mopping, until the perforation was visible. The randomised solution was flushed through the middle ear and eustachian tube using a 'tragal pump' technique: saline was used as the solution for flushing in the boric acid powder arm. Patients allocated topical ear medication were given a bottle of eardrops to administer (six drops twice daily, 'pumped in') until finished. Those allocated boric acid powder had the external ear canals filled as a one-off treatment. Patients were followed up monthly thereafter. OUTCOME MEASURES: Primary: Dry (inactive) middle ears as assessed by the doctor. Secondary: Patient assessment of success; microbiologic culture and sensitivity; audiologic changes because of treatment; complications of treatment; costs of therapies. RESULTS: Ciprofloxacin eardrops and boric acid powder were statistically superior to 1% acetic acid eardrops in rendering active chronic otitis media inactive (73% dry ears for ciprofloxacin; 67% for boric acid powder; and 24% for acetic acid). There was no difference between the success rates of ciprofloxacin eardrops and boric acid powder. Quadriderm cream was effective in 85% of patients failing first-line therapy. No agent caused significant complications and specifically no hearing loss. CONCLUSIONS: This study showed a single application of boric acid powder following external auditory canal irrigation until the perforation was visible to be as effective as the current best practice of topical quinolone eardrops in active chronic otitis media. Boric acid powder is inexpensive and does not require patient compliance. Boric acid powder is a viable, less costly alternative to topical antibiotic/steroid ear drops in the developing world for active chronic otitis media. Acetic acid eardrops 1% are ineffective. Quadriderm cream, given as a one-off therapy, also appears to be effective.
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Ácido Acético/administración & dosificación , Ácidos Bóricos/administración & dosificación , Ciprofloxacina/administración & dosificación , Otitis Media/tratamiento farmacológico , Administración Tópica , Adulto , Análisis de Varianza , Antiinfecciosos/administración & dosificación , Audiometría , Valerato de Betametasona , Distribución de Chi-Cuadrado , Enfermedad Crónica , Clioquinol , Farmacorresistencia Bacteriana , Femenino , Gentamicinas , Pérdida Auditiva/epidemiología , Humanos , Masculino , Otitis Media/microbiología , Estudios Prospectivos , Tolnaftato , Resultado del TratamientoRESUMEN
AIM: To investigate the incidence of metastasis to the submandibular gland in patients with head and neck squamous cell carcinoma. METHODS: We retrospectively evaluated histological reports of neck dissections for upper respiratory tract carcinoma (performed 2002-2009), recording: primary tumour site, tumour-node-metastasis stage, level Ib involvement, previous radiotherapy, perineural invasion, lymphovascular invasion, extracapsular spread, and the presence of malignant disease in the submandibular gland. RESULTS: We evaluated 107 cases. The most common primary site was the oral cavity (49 per cent) followed by the supraglottis (21 per cent), glottis (14 per cent), oropharynx (9 per cent) and hypopharynx (6 per cent). Forty-eight per cent of patients had advanced local disease, with 21 per cent at tumour stage 3 and 27 per cent at tumour stage 4. Fifty-six per cent had cervical lymph node metastasis, and 8 per cent received pre-operative radiotherapy. Forty-eight per cent had perineural invasion, 46 per cent lymphovascular spread, 27 per cent extracapsular spread and 8 per cent level Ib metastasis. Only one patient had submandibular gland involvement, due to direct spread (a case with prior radiotherapy and macroscopic submandibular gland involvement evident peri-operatively). CONCLUSION: Submandibular gland metastasis from head and neck primary squamous cell carcinoma is extremely rare. Preservation of the ipsilateral submandibular gland during neck dissection is oncologically safe, except in patients with prior surgery or radiotherapy, or a primary tumour in close relation to the gland.
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Carcinoma/cirugía , Neoplasias de Cabeza y Cuello/cirugía , Disección del Cuello/métodos , Neoplasias de Células Escamosas/cirugía , Neoplasias de la Glándula Submandibular/secundario , Glándula Submandibular/cirugía , Carcinoma/epidemiología , Carcinoma/patología , Carcinoma de Células Escamosas , Neoplasias de Cabeza y Cuello/epidemiología , Neoplasias de Cabeza y Cuello/patología , Humanos , Metástasis Linfática , Invasividad Neoplásica , Estadificación de Neoplasias , Neoplasias de Células Escamosas/epidemiología , Neoplasias de Células Escamosas/patología , Estudios Retrospectivos , Saliva , Carcinoma de Células Escamosas de Cabeza y Cuello , Glándula Submandibular/patología , Neoplasias de la Glándula Submandibular/epidemiología , Neoplasias de la Glándula Submandibular/cirugía , Resultado del Tratamiento , Xerostomía/etiología , Xerostomía/prevención & controlRESUMEN
We present a case report and review the world literature concerning otosyphilis, particularly with reference to the HIV positive patient. Our patient received two separate courses of treatment for otosyphilis. A course of intramuscular penicillin and oral prednisone resulted in no improvement in his hearing thresholds. A subsequent course of intravenous penicillin and oral prednisone resulted in an improvement of 79 db in his three frequency pure tone average. Otosyphilis is one of the rare causes of treatable sensorineural hearing loss. HIV has been shown to increase the severity and the progression of luetic ear disease. This case reveals that the optimal treatment remains a 10 day course of intravenous penicillin and oral prednisone.
Asunto(s)
Diatermia/instrumentación , Epistaxis/terapia , Adulto , Anciano , Diatermia/métodos , Endoscopía , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pacientes Ambulatorios , Estudios Prospectivos , SudáfricaRESUMEN
OBJECTIVES: To determine whether the way in which temporalis fascia is treated during myringoplasty affects the rate of successful perforation closure. DESIGN: A randomised controlled trial. SETTING: A tertiary ENT Department within the Tygerberg Academic Hospital. PARTICIPANTS: One hundred and fifty patients with perforations between 30% and 70% of the surface area of the eardrum undergoing elective myringoplasty were randomised into three groups by the way in which the temporalis fascia used was treated prior to insertion: fresh fascia; dried fascia; and fascia which was dried and then rehydrated. MAIN OUTCOME MEASURES: The outcome measure was intactness of the tympanic membrane 6 weeks after surgery. Preoperative and follow-up audiometry was obtained, but was not evaluated as an outcome measure. RESULTS: Successful closure of the perforation was achieved in 89% in the dried fascia group (42 of 47 patients), 84% in the fresh fascia group (37 of 44 patients), and 85% in the dried and rehydrated group (39 of 46 patients). The study showed no statistically significant difference between the three groups (P = 0.728). The study would have to had more than 800 patients in each group to have the power to show a 5% difference in take rates. CONCLUSIONS: While the dessication of temporalis fascia prior to use in myringoplasy results in degeneration of cellular and stromal elements histologically, this does not affect the successful closure of perforations. Clinicians should feel free to prepare the fascia in whichever way they find easiest to work with.
Asunto(s)
Desecación , Fascia/trasplante , Fluidoterapia , Miringoplastia/métodos , Perforación de la Membrana Timpánica/cirugía , Humanos , Músculo Temporal , Resultado del TratamientoRESUMEN
OBJECTIVES: To investigate missed appointments in a South African tertiary hospital. STUDY DESIGN: Prospective, descriptive series with controls. SETTING: The ENT/Oncology clinic at Tygerberg Academic Hospital, South Africa. SUBJECT: 305 patients with a head and neck malignancy who had follow-up appointments over 4 consecutive months between June and September 2006. A control group of 31 patients who attended the clinic was recruited in September 2006. METHOD: Analysis of the clinic attendance statistics to identify patients who missed follow-up appointments followed by a file review and interview of these patients. The results were compared with a control group. OUTCOME MEASURES: 1) Incidence rate of failure to attend follow-up. 2) Causative factors. RESULTS: 51 (17%) booked patients missed their appointments. Non-attenders were most likely to miss their follow-up between 6 and 12 months (17/31) after treatment. No correlations were found between diagnosis, disease stage and missed appointments. Reasons include: transport (19 responses), ill-health (6) and financial constraints (5). State transport was unavailable to almost two-thirds of the responders who cited transport as a problem. CONCLUSIONS: The 17% missed appointment rate is largely due to transport constraints. The commonest time for patients to miss appointments is the 6-12 month follow-up period. The authors seek to identify patients at risk of missed appointments and suggest interventions to decrease this incidence.
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Citas y Horarios , Neoplasias de Cabeza y Cuello , Cooperación del Paciente/estadística & datos numéricos , Pacientes Desistentes del Tratamiento/psicología , Estudios de Casos y Controles , Humanos , Incidencia , Servicio Ambulatorio en Hospital , Aceptación de la Atención de Salud , Pacientes Desistentes del Tratamiento/estadística & datos numéricos , Estudios Prospectivos , SudáfricaRESUMEN
Objectives: To investigate missed appointments in a South African tertiary hospital. Study Design: Prospective; descriptive series with controls. Setting: T he ENT/Oncology clinic at Tygerberg Academic Hospital; South Africa. Subjects: 305 patients with a head and neck malignancy who had follow-up appointments over 4 consecutive months between June and September 2006. A control group of 31 patients who attended the clinic was recruited in September 2006. Method: Analysis of the clinic attendance statistics to identify patients who missed follow-up appointments followed by a file review and interview of these patients. The results were compared with a control group. Outcome measures: 1) Incidence rate of failure to attend follow-up. 2) Causative factors Results: 51 (17) booked patients missed their appointments. Non-attenders were most likely to miss their follow-up between 6 and 12 months (17/31) after treatment. No correlations were found between diagnosis; disease stage and missed appointments. Reasons include: transport (19 responses); ill-health (6) and financial constraints (5). State transport was unavailable to almost twothirds of the responders who cited transport as a problem. Conclusions: The 17 missed appointment rate is largely due to transport constraints. The commonest time for patients to miss appointments is the 6-12 month follow-up period. The authors seek to identify patients at risk of missed appointments and suggest interventions to decrease this incidence
Asunto(s)
Citas y Horarios , Estudios de Casos y Controles , Estudios de Seguimiento , Neoplasias , Pacientes AmbulatoriosRESUMEN
OBJECTIVE: The aim of this study was to determine an accurate indicator of the need for second aspiration of peritonsillar abscesses the day after initial aspiration. SETTING: A tertiary otolaryngology care centre. PARTICIPANTS: Fifty patients aged between 11 and 49 years with suspected peritonsillar abscess. STUDY DESIGN: A prospective case series. OUTCOME MEASURES: The potential indicators investigated included volume of pus at initial aspiration and clinical indicators suggesting persistent pus (dysphagia, odynophagia and trismus). The outcome measure was the presence of pus at subsequent aspiration. RESULTS: A linear correlation was found between volume of first aspirate and presence of pus on re-aspiration (r = 0.9753). A volume of pus <3 mL on initial aspiration accurately predicted <0.5 mL pus on re-aspiration. Sixty-four per cent (32) patients had 3 mL or more pus on initial aspiration and in all there was at least 1 mL or more pus on second aspiration. Clinical indicators correlated less well, with a average coefficient on first aspiration of 0.62 and on second aspiration of 0.35. CONCLUSION: The volume of pus on initial aspiration is a very reliable indicator in assessing the need for re-aspiration of peritonsillar abscesses. If 3 mL or more of pus are aspirated on the first occasion these patients should be seen the next day and have a further aspiration. Clinical symptoms and signs are not useful indicators.
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Absceso Peritonsilar/terapia , Succión , Adolescente , Adulto , Niño , Femenino , Humanos , Masculino , Persona de Mediana Edad , Absceso Peritonsilar/diagnóstico , Pronóstico , Estudios Prospectivos , Retratamiento , Estadística como Asunto , Supuración/diagnósticoRESUMEN
Emergency tracheostomy prior to laryngectomy for laryngeal carcinoma has been associated with peristomal recurrence. Is the peristomal recurrence caused by the tracheostomy per se, or is it due to the association of tracheostomy with subglottic tumours and locally advanced tumours? This study examines the association between tracheostomy, as an independent variable, and peristomal recurrence. Forty-three patients with T3 glottic carcinomas and treated by a combination of total laryngectomy and radiotherapy were studied. The difference in peristomal recurrence between the tracheostomy and non-tracheostomy patients was not statistically significant. Nor was there a correlation between the time interval between tracheostomy and laryngectomy, and the incidence of peristomal recurrence. It is concluded that tracheostomy, as an independent variable, does not cause peristomal recurrence.