Training in cognitive reappraisal normalizes whole-brain indices of emotion regulation in borderline personality disorder.

BACKGROUND: Borderline personality disorder is the prototypical disorder of emotion dysregulation. We have previously shown that borderline personality disorder patients are impaired in their capacity to engage cognitive reappraisal, a frequently-employed adaptive emotion regulation strategy. METHODS: Here we report on the efficacy of longitudinal training in cognitive reappraisal to enhance emotion regulation in borderline patients. Specifically, the training targeted psychological distancing, a reappraisal tactic whereby negative stimuli are viewed dispassionately as though experienced by an objective, impartial observer. At each of 5 sessions over 2 weeks, 22 borderline (14 Female) and 22 healthy control (13 Female) participants received training in psychological distancing and then completed a widely-used picture-based reappraisal task. Self-reported negative affect ratings and functional magnetic resonance imaging (fMRI) data were acquired at the first and fifth sessions. In addition to behavioral analyses, we performed whole-brain pattern expression analyses using independently-defined patterns for negative affect and cognitive reappraisal implementation for each session. RESULTS: Borderline patients showed a decrease in negative affect pattern expression following reappraisal training, reflecting a normalization in neural activity. They did not, however, show significant change in behavioral self-reports. CONCLUSIONS: To our knowledge, this study represents the first longitudinal fMRI examination of task-based cognitive reappraisal training. Using a brief, proof-of-concept design, the results suggest a potential role for reappraisal training in the treatment of borderline patients.

Social support and adaptive emotion regulation: Links between social network measures, emotion regulation strategy use, and health.

Social support, as perceived and experienced within one's social network, has been associated with greater well-being and favorable health outcomes. The transition to college marks a critical time in which social support not only strengthens interpersonal bonds, but also may help an individual discover and utilize various coping strategies to lower risks associated with negative emotions, which may result in better health and well-being. In the present study, we collected data from a large sample of undergraduate students (N = 376) and conducted preregistered analyses to examine links between students' perceived social support in residential college communities, patterns of emotion regulation strategy use, and multiple indicators of health and well-being. Overall, we found partial support for our hypotheses, with some associations between social support and patterns of emotion regulation strategy use, as well as associations between strategy use and health indicators. All results held when adjusting for participants' age and gender. Taken together, the present findings revealed reliable links between social network indicators, emotion regulation strategy use, and health. Future research can extend these findings by observing how these relationships unfold over time, to better understand how people manage their emotions by drawing on their personal networks. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Perceived stress moderates emotion regulation success in real-world contexts: an ecologically-valid multilevel investigation.

BACKGROUND: Emotion regulation plays a crucial role in well-being in everyday life. Effective emotion regulation depends upon adaptively matching a given strategy to a given situation. Recent research has begun to explore these interactions in the context of daily reports of perceived stress, affect, and emotion regulation strategy usage. To further understand these differences in strategy efficacy in an ecologically valid context, we examined responses to real world stressors in a young adult sample. METHODS: We surveyed a range of emotion regulation strategies, including two forms of cognitive reappraisal (i.e., reinterpretation, which involves cognitively reframing one's emotional responses, and psychological distancing, which involves adopting an objective, impartial perspective). Participants reported strategy usage, momentary perceived stress, and affect in response to multiple ecological momentary assessments over a period of 7 days. RESULTS: Analyses of links between strategy usage and affect revealed that rumination was significantly negatively associated with more positive affect ratings. Further, a significant interaction between momentary perceived stress and reinterpretation usage was observed on affect, such that reinterpretation was more adaptive during situations perceived as less stressful. CONCLUSION: These results provide further insight into the importance of situational context in determining the effectiveness of particular emotion regulation strategies.

Unpacking reappraisal: a systematic review of fMRI studies of distancing and reinterpretation.

In recent decades, a substantial volume of work has examined the neural mechanisms of cognitive reappraisal. Distancing and reinterpretation are two frequently used tactics through which reappraisal can be implemented. Theoretical frameworks and prior evidence have suggested that the specific tactic through which one employs reappraisal entails differential neural and psychological mechanisms. Thus, we were motivated to assess the neural mechanisms of this distinction by examining the overlap and differentiation exhibited by the neural correlates of distancing (specifically via objective appraisal) and reinterpretation. We analyzed 32 published functional magnetic resonance imaging (fMRI) studies in healthy adults using multilevel kernel density analysis. Results showed that distancing relative to reinterpretation uniquely recruited right bilateral dorsolateral PFC (DLPFC) and left posterior parietal cortex, previously associated with mentalizing, selective attention and working memory. Reinterpretation relative to distancing uniquely recruited left bilateral ventrolateral PFC (VLPFC), previously associated with response selection and inhibition. Further, distancing relative to reinterpretation was associated with greater prevalence of bilateral amygdala attenuation during reappraisal. Finally, a behavioral meta-analysis showed efficacy for both reappraisal tactics. These results are consistent with prior theoretical models for the functional neural architecture of reappraisal via distancing and reinterpretation and suggest potential future applications in region-of-interest specification and neural network analysis in studies focusing on specific reappraisal tactics.

Brief training in regulation of craving reduces cigarette smoking.

INTRODUCTION: Craving is an important contributing factor in cigarette smoking and has been added as a diagnostic criterion for addiction in the DSM-5. Cognitive-behavioral therapy and other treatments that incorporate craving regulation strategies reduce smoking and the likelihood of relapse. Although this finding suggests that the regulation of craving is an important mechanism underlying smoking cessation, whether targeted interventions that train smokers to regulate craving can directly impact real-world smoking behaviors is unclear. METHOD: Across two pilot studies (N = 33; N = 60), we tested whether a brief, computer-delivered training session in the cognitive regulation of craving altered subsequent smoking behaviors in daily life. The study first randomly assigned participants to either a no training (control) group, or one of two Regulation of Craving Training (ROC-T) conditions. Next, all participants came into the lab and those assigned to ROC-T conditions were trained to implement a cognitive strategy to regulate their craving, by either focusing on the negative consequences of smoking, or by distracting themselves. Then, these participants underwent ROC-T during which they practiced using the strategy to regulate their craving during cue exposure. The study subsequently assessed participants' smoking via daily diaries for 3-6 days, and via self-report up to 1-month follow-up. RESULTS: Across both studies, ROC-T conditions were associated with significant reductions in average cigarettes smoked per day, with effects persisting through follow-up. CONCLUSION: These results confirm that the regulation of craving is an important mechanism of smoking cessation, and can be targeted via easily administered training procedures, such as ROC-T.

Regulating Self-Image on Instagram: Links Between Social Anxiety, Instagram Contingent Self-Worth, and Content Control Behaviors.

Social media platforms have provided human beings with unprecedented ways to virtually connect with one another, creating a novel and complex arena for psychological research. Indeed, a growing body of research has uncovered links between social media use and various aspects of health and wellbeing. However, relatively little work has examined factors that characterize how people experience and regulate their online selves on particular platforms. In the present study, we recruited a large sample of active Instagram users (N = 247; ages 18-58) to complete a questionnaire battery that included measures of participants' social anxiety, their sense of self-worth tied to Instagram use, and specific content control behaviors on the Instagram platform (e.g., editing captions, disabling comments, etc.). Results indicated that participants with higher levels of social anxiety tended to have greater Instagram contingent self-worth, and this was then associated with some content control behaviors, including editing captions and photos and videos when sharing posts. These findings suggest that those who are more socially anxious interact with Instagram differently, and this may arise from self-worth that is wedded to their experiences on the platform. Overall, this work adds to a growing body of research highlighting the benefits and risks of social media use on psychological health.

Novel computational algorithms to index lexical markers of psychological distancing and their relationship to emotion regulation efficacy over time.

The degree to which one employs an objective or spatially/temporally distant perspective via language, i.e., linguistic distancing, has previously been shown to be positively associated with well-being. We sought to further elucidate relationships among language and emotion over time as a function of the implementation of sub-tactics of psychological distancing. In Study 1, we developed novel deep machine learning algorithms to identify the degree to which linguistic patterns reflect two types of psychological distancing, namely objective (OBJ) and spatial/temporal (FAR) distancing. In Study 2, in an expressive writing-based longitudinal emotion regulation training task, participants transcribed their thoughts while viewing negative or neutral stimuli over 5 sessions in one of three ways: by implementing objective language (Objective group), by implementing spatially/temporally distant language (Far group), or by responding naturally. We found that the OBJ and FAR algorithms significantly predicted changes in task-based self-reported negative affect in the Objective group and found no significant associations in the Far group. The relationship between the algorithm scores and self-reported negative affect was stronger in the Objective group compared to the Far group. These findings describe sensitive linguistic distancing algorithms that are capable of tracking changes in self-reported negative affect. These results may be useful in developing novel, unobtrusive emotion regulation assessments and interventions that utilize natural language processing.

Neural Indicators Of Food Cue Reactivity, Regulation, And Valuation And Their Associations With Body Composition And Daily Eating Behavior.

Exposure to food cues activates the brain's reward system and undermines efforts to regulate impulses to eat. During explicit regulation, lateral prefrontal cortex activates and modulates activity in reward regions and decreases food cravings. However, it is unclear the extent to which between-person differences in recruitment of regions associated with reward processing, subjective valuation, and regulation during food cue exposure-absent instructions to regulate-predict body composition and daily eating behaviors. In this preregistered study, we pooled data from five fMRI samples (N = 262) to examine whether regions associated with reward, valuation, and regulation, as well as whole-brain pattern expression indexing these processes, were recruited during food cue exposure and associated with body composition and real-world eating behavior. Regression models for a single a priori analytic path indicated that univariate and multivariate measures of reward and valuation were associated with individual differences in BMI and enactment of daily food cravings. Specification curve analyses further revealed reliable associations between univariate and multivariate neural indicators of reactivity, regulation, and valuation, and all outcomes. These findings highlight the utility of these methods to elucidate brain-behavior associations and suggest that multiple processes are implicated in proximal and distal markers of eating behavior.

Media multitasking is associated with higher risk for obesity and increased responsiveness to rewarding food stimuli.

Obesity among children and adolescents has dramatically increased over the past two to three decades and is now a major public health issue. During this same period, youth exposure to media devices also became increasingly prevalent. Here, we present the novel hypothesis that media multitasking (MMT)-the simultaneous use of and switching between unrelated forms of digital media-is associated with an imbalance between regulatory processes and reward-related responses to appetitive food stimuli, resulting in a greater sensitivity to external food cues among high media multitaskers. This, in turn, may contribute to overeating and weight gain over time. To test this hypothesis, we conducted two studies examining research participants who grew up during the recent period of escalating multitasking and obesity-and among whom 37% are overweight or obese. In Study 1, participants' propensity to engage in MMT behaviors was associated with a higher risk for obesity (as indicated by higher body mass index and body fat percentage). Next, in Study 2, a subset of participants from Study 1 were exposed to appetitive food cues while undergoing functional neuroimaging and then, using passive mobile sensing, the time participants spent in various food points-of-sale over an academic term was inferred from GPS coordinates of their mobile device. Study 2 revealed that MMT was associated with an altered pattern of brain activity in response to appetizing food cues, specifically an imbalance favoring reward-related activity in ventral striatum and orbitofrontal cortex-relative to recruitment of the frontoparietal control network. This relationship was further tested in a mediation model, whereby increased MMT, via a brain imbalance favoring reward over control, was associated with greater time spent in campus eateries. Taken together, findings from both studies suggest the possibility that media multitasking may be implicated in the recent obesity epidemic.

Emotion Regulation and Immune Functioning During Grief: Testing the Role of Expressive Suppression and Cognitive Reappraisal in Inflammation Among Recently Bereaved Spouses.

OBJECTIVE: Losing a spouse is a distressing life event that can negatively affect both mental and physical health. Stress-induced health consequences often include increased risk of cardiovascular disease and altered immune system functioning marked by increased inflammation. Here, we sought to identify individual difference factors that covary with problematic inflammatory outcomes. METHOD: We measured recently bereaved spouses' (n = 99) propensity to use emotion regulation strategies and peripheral inflammation, as measured by levels of proinflammatory cytokines after ex vivo stimulation of peripheral leukocytes with T-cell agonists. Specifically, we measured participants' use of cognitive reappraisal, an adaptive emotion regulation strategy in many contexts, and expressive suppression, a less adaptive emotion regulation strategy that involves actively inhibiting emotions after already experiencing them. RESULTS: Bereaved spouses who self-reported frequently using expressive suppression as an emotion regulation strategy tended to have a more pronounced inflammatory response, as indexed by higher levels of a composite cytokine index consisting of interleukin (IL) 17A, IL-2, IL-6, tumor necrosis factor α, and interferon-γ (b = 0.042), as well as tumor necrosis factor α (b = 0.083) and interferon-γ (b = 0.098) when analyzed individually. Notably, these associations were observed in both unadjusted and adjusted models, with the latter including known covariates of inflammation and other potential confounding variables. CONCLUSIONS: These findings suggest that bereaved spouses' use of emotion regulation strategies is associated with altered immune functioning, and such a link may be an important biological pathway by which interventions targeting affect may improve immune system-related health outcomes.

Media Multitasking Is Associated With Higher Body Mass Index in Pre-adolescent Children.

Obesity rates among children have climbed dramatically in the past two decades, a time period in which children also experienced greater exposure to portable media devices and smartphones. In the present study, we provide evidence of a potential link between media multitasking - using and switching between unrelated forms of digital media - and risk for obesity, as indexed by body mass index (BMI). Specifically, we recruited 179 pre-adolescent children (aged 9-11 years, 88 females) to participate in a study in which we assessed their media multitasking (MMT) tendencies, as well as BMI. Controlling for the influence of a known genetic risk factor for obesity and other covariates, including physical activity, we found a positive association between the frequency of children's MMT behaviors and age- and sex-standardized BMI z-scores, b = 1.07, p = 0.011. These findings are consistent with other recent work showing similar patterns of covariation between MMT and risk for obesity in young adults. The present work can also inform future work in this realm, such as the design of longitudinal studies that prospectively measure children's MMT behaviors and body composition to begin to identify directionality in the association.

Fusing Mobile Phone Sensing and Brain Imaging to Assess Depression in College Students.

As smartphone usage has become increasingly prevalent in our society, so have rates of depression, particularly among young adults. Individual differences in smartphone usage patterns have been shown to reflect individual differences in underlying affective processes such as depression (Wang et al., 2018). In the current study, a positive relationship was identified between smartphone screen time (e.g., phone unlock duration) and resting-state functional connectivity (RSFC) between the subgenual cingulate cortex (sgCC), a brain region implicated in depression and antidepressant treatment response, and regions of the ventromedial/orbitofrontal cortex (OFC), such that increased phone usage was related to stronger connectivity between these regions. This cluster was subsequently used to constrain subsequent analyses looking at individual differences in depressive symptoms in the same cohort and observed partial replication in a separate cohort. Similar analyses were subsequently performed on metrics of circadian rhythm consistency showing a negative relationship between connectivity of the sgCC and OFC. The data and analyses presented here provide relatively simplistic preliminary analyses which replicate and provide an initial step in combining functional brain activity and smartphone usage patterns to better understand issues related to mental health. Smartphones are a prevalent part of modern life and the usage of mobile sensing data from smartphones promises to be an important tool for mental health diagnostics and neuroscience research.

Recruitment of cognitive control regions during effortful self-control is associated with altered brain activity in control and reward systems in dieters during subsequent exposure to food commercials.

Engaging in effortful self-control can sometimes impair people's ability to resist subsequent temptations. Existing research has shown that when chronic dieters' self-regulatory capacity is challenged by prior exertion of effort, they demonstrate disinhibited eating and altered patterns of brain activity when exposed to food cues. However, the relationship between brain activity during self-control exertion and subsequent food cue exposure remains unclear. In the present study, we investigated whether individual differences in recruitment of cognitive control regions during a difficult response inhibition task are associated with a failure to regulate neural responses to rewarding food cues in a subsequent task in a cohort of 27 female dieters. During self-control exertion, participants recruited regions commonly associated with inhibitory control, including dorsolateral prefrontal cortex (DLPFC). Those dieters with higher DLPFC activity during the initial self-control task showed an altered balance of food cue elicited activity in regions associated with reward and self-control, namely: greater reward-related activity and less recruitment of the frontoparietal control network. These findings suggest that some dieters may be more susceptible to the effects of self-control exertion than others and, whether due to limited capacity or changes in motivation, these dieters subsequently fail to engage control regions that may otherwise modulate activity associated with craving and reward.

Implicit reappraisal as an emotional buffer: Reappraisal-related neural activity moderates the relationship between inattention and perceived stress during exposure to negative stimuli.

Emotion regulation often is an adaptive option in the face of elevated perceived stress. Perceived stress has been shown to have negative consequences for physical and mental health, including cognitive deficits and difficulties controlling attention. Cognitive reappraisal is an emotion regulation strategy that involves changing one's cognitive construal of an emotionally evocative stimulus to alter its emotional impact. Reappraisal can be implemented explicitly or implicitly (i.e., with or without conscious awareness). The objective of the present study was to examine whether implicit cognitive reappraisal during exposure to negative stimuli moderates the relationship between inattention and perceived stress. We found, as expected, that inattention problems are associated with increased perceived stress, but also found that one's spontaneous propensity to engage in cognitive reappraisal-as indexed by correspondence with a reliable thresholded whole-brain pattern of reappraisal implementation-moderated the relationship between inattention and perceived stress. Overall, the current study provides evidence that spontaneous reappraisal recruitment has a buffering effect on the relationship between inattention and perceived stress.

Reducing reward responsivity and daily food desires in female dieters through domain-specific training.

According to the strength model, self-regulation relies on a domain-general capacity that may be strengthened by training. From this perspective, training self-regulation in one domain may transfer to other domains. Here we used two inhibitory training paradigms, a domain-general and domain-specific stop-signal training task and compared their effects on brain reward activity as well as daily food desires in female dieters. Before and after the training, functional magnetic resonance imaging was used to assess food cue-reactivity, coupled with one week of smart-phone ecological momentary assessments to examine eating urges. Whereas the food-specific inhibitory training was successful in reducing both food cue-reactivity and food desires, the domain-general (sound-cue) training showed no transfer effects. These findings suggest that domain-specific training may be a more effective method for supporting self-regulation than domain-general approaches aimed at strengthening self-regulation across domains.

Neural mechanisms of emotion regulation and their role in endocrine and immune functioning: A review with implications for treatment of affective disorders.

In the past century, medical progress has helped increase life expectancy and improve health outcomes more generally. Despite this progress, psychiatric disorders-especially affective disorders including depressive and anxiety disorders-are quite common and have been linked to dysfunction in endocrine and immune systems. In this review, we discuss neurobiological correlates of emotion regulation strategies and their effects on mental and physical health. Some of these correlates, namely sub-regions of prefrontal cortex, also play a key regulatory role in autonomic, endocrine, and immunological processes. Given this functional overlap, we propose a novel neuro-immuno-affective framework that targets improving emotion regulation, in order to: (1) reduce negative affect associated with depressive and/or anxiety disorders; and (2) alter endocrine and immune system functioning (e.g., reduce inflammation)-via changes in activity within (and connectivity between) brain systems that support (successful) emotion regulation. We conclude by arguing that such a framework can be adapted for psychiatric treatment protocols that holistically incorporate neural and immunological biomarkers to promote mental and physical health.

Media multitasking is associated with altered processing of incidental, irrelevant cues during person perception.

BACKGROUND: Media multitasking (MMT)-using and switching between unrelated forms of media-has been implicated in altered processing of extraneous stimuli, resulting in performance deficits. Here, we sought to extend our prior work to test the hypothesis that MMT might be associated with enhanced processing of incidental environmental cues during person perception. METHOD: We tested the relationship between individual differences in MMT and person perception, by experimentally manipulating the relevance of environmental cues that participants could use to make trait and personality judgements of an unfamiliar social target. Relevant environmental cues consisted of neat or messy arrangements of the target's belongings, whereas irrelevant cues consisted of similarly neat or messy arrangements of the testing room in which participants viewed a video of the target. RESULTS: In general, relevant cues affected ratings of the target's conscientiousness. Additionally, and consistent with our hypothesis, there was a significant interaction between irrelevant cue condition and MMT, such that high media multitaskers more readily incorporated irrelevant environmental cues into their evaluations of the target's conscientiousness. CONCLUSIONS: These results suggest that high media multitaskers are more responsive to irrelevant environmental cues, which in turn can lead them to form inaccurate impressions of others.

Cognitive reappraisal of low-calorie food predicts real-world craving and consumption of high- and low-calorie foods in daily life.

In an increasingly obesogenic environment, an individual's regulatory capacity to pursue nutrient-rich, low-calorie foods over palatable, energy-dense items is essential to maintaining a healthy weight and preventing the detrimental health risks of obesity. Cognitive reappraisal, the process by which one changes the meaning of a stimulus by altering its emotional impact (or in this case, its appetitive value) demonstrates promise as a regulatory strategy to decrease obesogenic food consumption, but little research has directly addressed the relationship between cognitive reappraisal of food cravings and real-world eating behaviors. Additionally, research examining self-regulation of eating has typically focused exclusively on diminishing cravings and consumption of unhealthy, high-calorie foods, rather than examining, in tandem, ways to strengthen (or, up-regulate) cravings for healthier, low-calorie alternatives. In the present study, fifty-seven college aged participants first completed a cognitive reappraisal task in the laboratory in which they practiced regulating their craving responses to high- and low-calorie food items by focusing on the long-term health consequences of repeatedly consuming the pictured foods. Next, for a week following the laboratory session, participants reported daily eating behaviors via ecological momentary assessment. Participants who reported greater up-regulatory success during the reappraisal task also reported increased craving strength for low-calorie foods as well as decreased consumption of high-calorie foods in their daily lives. Greater overall regulation success also predicted more frequent consumption of craved low-calorie foods. These findings substantiate the association between cognitive reappraisal ability and real-world appetitive behaviors, and suggest that future interventions may benefit from specifically targeting individuals' evaluations of low-calorie foods.

Minding One's Reach (To Eat): The Promise of Computer Mouse-Tracking to Study Self-Regulation of Eating.

In this review, we present the case for using computer mouse-tracking techniques to examine psychological processes that support (and hinder) self-regulation of eating. We first argue that computer mouse-tracking is suitable for studying the simultaneous engagement of-and dynamic interactions between-multiple perceptual and cognitive processes as they unfold and interact over a fine temporal scale (i.e., hundreds of milliseconds). Next, we review recent work that implemented mouse-tracking techniques by measuring mouse movements as participants chose between various food items (of varying nutritional content). Lastly, we propose next steps for future investigations to link behavioral features from mouse-tracking paradigms, corresponding neural correlates, and downstream eating behaviors.

A balance of activity in brain control and reward systems predicts self-regulatory outcomes.

Previous neuroimaging work has shown that increased reward-related activity following exposure to food cues is predictive of self-control failure. The balance model suggests that self-regulation failures result from an imbalance in reward and executive control mechanisms. However, an open question is whether the relative balance of activity in brain systems associated with executive control (vs reward) supports self-regulatory outcomes when people encounter tempting cues in daily life. Sixty-nine chronic dieters, a population known for frequent lapses in self-control, completed a food cue-reactivity task during an fMRI scanning session, followed by a weeklong sampling of daily eating behaviors via ecological momentary assessment. We related participants' food cue activity in brain systems associated with executive control and reward to real-world eating patterns. Specifically, a balance score representing the amount of activity in brain regions associated with self-regulatory control, relative to automatic reward-related activity, predicted dieters' control over their eating behavior during the following week. This balance measure may reflect individual self-control capacity and be useful for examining self-regulation success in other domains and populations.