Assessment and analysis of the balance between economic development and ecological environment protection and its implementation strategy derived from spatial planning-Take three heterogeneous and representative provinces in China as an example.

Balancing ecological environment protection (EEP) and economic development (ED) (balance for short) is a difficult problem that must be solved in the development of modern society, particularly important for realizing UN Sustainable Development Goals. How to assess the regional balance situation and reveal the spatial and temporal heterogeneous characteristics of the balance (especially for the vast China) and its influencing factors are the primary scientific problems and realistic needs. Taking Zhejiang, Hunan and Gansu Provinces in the eastern, central and western region of China as a regional representative, an index system characterizing EEP and ED were established, which were processed by extreme difference method and entropy weight method. The coupling characteristics, stress factors and coordination type from 2010 to 2019 in the 3 provinces were assessed and analyzed by means of the coupling coordination model and the grey correlation degree model. Balance is the mission and responsibility of the spatial planning system for spatial planning is of the source, whole-region and comprehensiveness of public strategy, therefore, the balance strategies and its integration approaches are constructed in the 3 provincial spatial planning based on the assessment and analysis of balance characteristics. Research results show that: (1) the 3 provinces' coupling coordination degree is rising year by year, coordination type is more and more better indicating that the balance of EEP and ED is getting better and better, but coordination type differentiates at one level between 3 provinces at the east, central, western region of China, Zhejiang province is from nearby imbalance to primary coordination, Hunan Province is from nearby imbalance to narrow coordination, and Gansu Province is from medium imbalance to nearby imbalance. (2) The ED have same strong stress on EEP in the 3 provinces, and the constraints of EEP on ED are different, the current balance characteristics of Zhejiang, Hunan and Gansu province are the types of ecological environment pressure constraints primary coordination, ecological environment pressure constraints narrow coordination, and ecological environment condition constraints nearby imbalance. (3) The coordination types are the co-environmental pressure constraints primary coordination (Zhejiang Province), eco-environmental pressure constraints narrow coordination (Hunan Province) and eco-environmental condition constraints nearby imbalance (Gansu Province), and corresponding balanced planning strategy system are to promote ecological modernization, implement ecological industrialization and adhere to the ecological fundamentalization.

The effect of self-directed online metacognitive listening practice on Chinese EFL learners' listening ability, metacognition, and self-efficacy.

Research into metacognitive listening instruction under the Metacognitive Pedagogical Cycle (MPC) has been growing in recent decades, but its effects on L2 listening comprehension, metacognitive awareness, and self-efficacy remain inconclusive. In this mixed-method study, we developed a self-directed online listening practice based on the MPC and investigated its effects on 89 Chinese intermediate EFL learners over 14 weeks. Learners were assigned to either an experimental group, which used the online metacognitive listening practice, or a control group, which used the traditional listening practice without stressing metacognitive awareness. Multiple data sources (listening tests, questionnaires, reflective notes, and interviews) were used to assess learners' listening comprehension, metacognitive awareness, and listening self-efficacy. Results showed that online metacognitive listening practice significantly improved the learners' listening comprehension, but there was little evidence that it increased metacognitive awareness or listening self-efficacy. This study suggests that deploying online listening practice under MPC is a more effective way to improve L2 learners' listening comprehension than traditional listening practice. However, the task-setting of MPC and the task-dependence of self-efficacy may constrain the development of some factors of metacognitive awareness and self-efficacy.

English Teachers' Conceptualizations of Key Competencies in English Language Teaching and Challenges to Their Implementation.

Limited empirical research on the key competencies of front-line English teachers, particularly primary and middle school English teachers in rural regions, exists in the current literature. This research focuses on front-line instructors and examines their mastery of the key competencies in English language teaching. Through in-depth interviews, this paper examined eight rural junior middle school English teachers on their understanding of developing students' key competencies in English language teaching, as well as the obstacles and challenges they experienced in curriculum implementation. The study found that although front-line teachers have a positive attitude toward the key competencies, there is still a certain gap between their comprehension of key competencies and policy requirements and practical demands. In order to implement core qualities and effectively promote curriculum reform, we need to strengthen teacher development training for front-line English teachers, especially for primary and secondary school English teachers in rural areas, to improve their understanding and professionalization of the new round of curriculum reform.

Propoxyphene Mediates Oxyhemoglobin-Induced Injury in Rat Cortical Neurons Through Up-Regulation of Active-ß-Catenin.

Wnt/ß-catenin signaling is involved in various biological processes, including the development of the central nervous system. The dysfunction of mitochondria has been shown to participate in the progress of subarachnoid hemorrhage (SAH). Traumatic subarachnoid hemorrhage (tSAH) is a serious complication in acute craniocerebral trauma. Opioids can activate the canonical Wnt/ß-catenin signaling pathway. c-Myc, a downstream protein of Wnt/ß-catenin signaling, contributes to the fusion of mitochondria. Here, we investigated the protective roles of Propoxyphene (Pro) against Oxyhemoglobin (OxyHb)-induced primary cultured neuron apoptosis. The data indicated that Pro rescued active-ß-catenin from OxyHb-induced decline. Furthermore, Pro attenuated OxyHb-induced apoptosis and fission of mitochondria in primary cortical neurons. However, the protective effects were abrogated under active-ß-catenin-deficient conditions. Together, the data presented here showed that Pro, a weak opioid analgesic drug, attenuates OxyHb-induced mitochondria-dependent apoptosis in an active-ß-catenin-c-Myc-dependent manner.