Differential effects of selective vagotomy and tropisetron in aminoprivic feeding.

Both total subdiaphragmatic vagotomy (TVAGX) and serotonin(3) receptor blockade with tropisetron or ondansetron attenuate amino acid-imbalanced diet (Imb) anorexia. Total vagotomy is less effective than tropisetron in reducing Imb-induced anorexia and also blunts the tropisetron effect. With the use of electrocautery at the subdiaphragmatic level of the vagus, we severed the ventral and dorsal trunks as well as the hepatic, ventral gastric, dorsal gastric, celiac, and accessory celiac branches separately or in combination to determine which vagal branches or associated structures may be involved in these responses. Rats were prefed a low-protein diet. On the first experimental day, tropisetron or saline was given intraperitoneally 1 h before presentation of Imb. Cuts including the ventral branch, i.e., TVAGX, ventral vagotomy (above the hepatic branch), and hepatic + gastric vagotomies (but not hepatic branch cuts alone) caused the highest (P < 0.05) Imb intake on day 1 with or without tropisetron. The responses to tropisetron were not affected significantly. On days 2-8, groups having vagotomies that included the hepatic branch recovered faster than sham-treated animals. Because the hepatic and gastric branches together account for most of the vagal innervation to the proximal duodenum, this area may be important in the initial responses, whereas structures served by the hepatic branch alone apparently act in the later adaptation to Imb.

Countertorque testing and histomorphometric analysis of various implant surfaces in canines: a pilot study.

As surface roughness may play a role in the mechanical attachment of an implant surface to bone, various implant surfaces have been prepared and analyzed by removal torque (countertorque) or push-out tests in a variety of animal model systems. Rougher surfaces generally have displayed higher mechanical testing values, indicating a stronger implant-bone interface. This pilot study was undertaken to test the countertorque values for integrated threaded implants with surfaces prepared by machining, blasting, and acid-etching, to compare the various implant surface types histomorphometrically for percentage of bone-implant contact under loaded and unloaded conditions, and to determine the degree of correlation between countertorque values and bone-implant contact with varying degrees of surface roughness. The results of this animal investigation suggest that the strength of the bone-implant interface, as determined by countertorque testing, is influenced by different surface characteristics. Acid-etched surfaces resisted countertorque forces more successfully as compared with blasted or machined surfaces. Histologic evaluation of bone contact with the various implant surfaces did not demonstrate a definite advantage for rougher surfaces in regard to percentage of bone contact at the light microscopic level.

Emprego de indometacina na sindrome de Bartter. / Use of indomethacin in Bartter's syndrome

Os autores apresentam um caso de paciente portador de sindrome de Bartter e analisam os efeitos da indometacina sobre a excrecao urinaria de sodio, potassio, cloro e aldosterona. A administracao de indometacina promoveu reducao na excrecao urinaria de potassio e aldosterona e do volume urinario. A excrecao de cloro, no entanto, nao apresentou variacoes significantes.Este fato sugere que o defeito primario desta sindrome possa independer da hiperproducao de prostaglandinas