RESUMEN
Systemic administration of antihistamine drug dimebon improves active avoidance conditioning in rats with chronic partial deprivation of cerebral cholinergic functions caused by intracerebroventricular injections of AF64A. The effects of dimebon on learning are similar to those of tacrine used in the treatment of Alzheimer's disease.
Asunto(s)
Enfermedad de Alzheimer/tratamiento farmacológico , Colina/análogos & derivados , Modelos Animales de Enfermedad , Antagonistas de los Receptores Histamínicos H1/farmacología , Indoles/farmacología , Enfermedad de Alzheimer/inducido químicamente , Enfermedad de Alzheimer/psicología , Animales , Reacción de Prevención/efectos de los fármacos , Aziridinas/farmacología , Colina/farmacología , Inhibidores de la Colinesterasa/farmacología , Inyecciones Intraventriculares , Masculino , Bloqueantes Neuromusculares/farmacología , Ratas , Ratas Wistar , Tacrina/farmacologíaRESUMEN
It was shown for the first time that estrogens 17 beta- and 17 alpha-estradiols compensate impaired cognitive functions in rats with partial chronic deprivation of cholinergic functions in the central nervous system induced by intracerebral administration of selective cholinergic neurotoxin AF64A. 17 beta-Estradiol produced strong dose-dependent changes in the weights of hormone-sensitive endocrine glands, while 17 alpha-estradiol did not affect the weight of the gonads and slightly influenced (in high concentration) the weights of the adrenal glands and thymus. The positive effects of exogenous 17 beta- and 17 alpha-estradiols on cognitive functions are due to their antioxidant properties, rather than due to specific action on hormone-sensitive endocrine glands.
