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Macromol Biosci ; 21(6): e2000424, 2021 06.
Artículo en Inglés | MEDLINE | ID: mdl-33811465

RESUMEN

How to precisely detect and effectively cure cancer which is defined as precise nanomedicine has drawn great attention worldwide. Polymeric nanoreactors which can in situ catalyze inert species into activated ones, can greatly increase imaging quality and enhance therapeutic effects along with decreased background interference and reduced serious side effects. After a brief introduction, the design and preparation of polymeric nanoreactors are discussed from the following aspects, that is, solvent-switch, pH-tuning, film rehydration, hard template, electrostatic interaction, and polymerization-induced self-assembly (PISA). Subsequently, the biomedical applications of these nanoreactors in the fields of cancer imaging, cancer therapy, and cancer theranostics are highlighted. The last but not least, conclusions and future perspectives about polymeric nanoreactors are given. It is believed that polymeric nanoreactors can bring a great opportunity for future fabrication and clinical translation of precise nanomedicine.


Asunto(s)
Portadores de Fármacos , Nanoestructuras/química , Neoplasias/terapia , Polímeros/síntesis química , Medicina de Precisión/métodos , Nanomedicina Teranóstica/métodos , Células A549 , Animales , Reactores Biológicos , Humanos , Concentración de Iones de Hidrógeno , Membranas Artificiales , Ratones , Nanoestructuras/administración & dosificación , Nanoestructuras/ultraestructura , Neoplasias/metabolismo , Neoplasias/patología , Polímeros/farmacocinética , Medicina de Precisión/instrumentación , Solventes/química , Electricidad Estática , Tensoactivos/química , Tensoactivos/farmacocinética , Nanomedicina Teranóstica/instrumentación , Ensayos Antitumor por Modelo de Xenoinjerto
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