RESUMEN
In the structure of the title co-crystal, C3H3N3O2·C5H8N2, the components are linked by a set of directional O-Hâ¯N, N-Hâ¯O, N-Hâ¯N and C-Hâ¯O hydrogen bonds to yield a two-dimensional mono-periodic arrangement. The structure propagates in the third dimension by extensive π-π stacking inter-actions of nearly parallel mol-ecules of the two components, following an alternating sequence. The primary structure-defining inter-action is very strong oxime-OH donor to pyrazole-N acceptor hydrogen bond [Oâ¯N = 2.587â (2)â Å], while the significance of weaker hydrogen bonds and π-π stacking inter-actions is comparable. The distinct structural roles of different kinds of inter-actions agree with the results of a Hirshfeld surface analysis and calculated inter-action energies. The title compound provides insights into co-crystals of active agrochemical mol-ecules and features the rational integration in one structure of a fungicide, C3H3N3O2, and a second active component, C5H8N2, known for alleviation the toxic effects of fungicides on plants. The material appears to be well suited for practical uses, being non-volatile, air-stable, water-soluble, but neither hygroscopic nor efflorescent.
RESUMEN
Dilatation of the main pancreatic duct (MPD) Ë50 mm is a rare phenomenon. We present the case of successful surgical treatment a 63-year-old female patient who presented epigastric pain and weight loss of 10 kg in 6 months. Based on preoperative examination, the dilatation of MPD was 75 mm. The preliminary diagnosis was main duct intraductal papillary mucinous neoplasm. Extended pylorus-preserving pancreatoduodenectomy with resection of the body of the pancreas was performed. According to the results of pathological and immunohistochemical studies, performed by independent experts, the final diagnosis of congenital anomaly of the ductal system and neuroendocrine tumor of the accessory pancreatic duct was made.