Placas purpúricas retiformes / Retiform Purpura in Plaques

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Incontinentia pigmenti and bipolar aphthosis: an unusual combination.

Incontinentia pigmenti (IP) is an uncommon X-linked dominant multisystem disorder, lethal in the majority of affected males in utero and variably expressed in females. The cutaneous manifestations are diagnostic and classically occur in four stages: vesicular, verrucous, hyperpigmented, and atrophic. The skin lesions are typically spread along the lines of Blaschko, and they are usually present at birth. It may be variably accompanied by dental, ocular, neurologic, bones and joints, and development anomalies. The genes IP has been mapped to Xq28. Mutations in the NEMO/IKKγ gene, located at Xq28, have been found to cause expression of the disease. Behçets disease is a multisystem disorder consisting of recurrent oral aphtae, genital ulcers, pustular skin eruption, and uveitis. Occasionally there are other articular, neurological, intestinal, or vascular abnormalities. This disease is rare in children. Here, we report a case of a 16-year-old female with the rare combination of incontinentia pigmenti and an aphthosis bipolar, and we discuss the probably relationship between these two diseases.

Eritema nodoso inducido por anillo vaginal / Vaginal ring inducing erythema nodosum

El eritema nodoso (EN) es la forma de paniculitis más común, y a su vez es considerado el prototipo de paniculitis septal. Este trastorno representauna reacción de hipersensibilidad frente a diferentes antígenos, así como múltiples enfermedades sistémicas y fármacos. Aunque en la mayoríade casos se desconoce la causa. Nuevos fármacos se añaden a la lista involucrados en la etiopatogenia del EN. Reportamos dos casos de EN en relacióncon el uso del anillo vaginal (AU)

Erythema nodosum (EN) represents the commonest form of nodular panniculitis and is the prototype of septal panniculitis. This disorder representsa hypersensitivity reaction in front of different antigens, such as several systemic diseases and drug therapies. In the majority of cases, the causeremains unknown. New drugs are being added to the list of drugs implicated in the etiopathogenesis of EN. We report two cases of EN in relationto the use of the vaginal ring (AU)

Pustulosis amicrobiana de las flexuras. Descripción de un nuevo caso y revisión de la literatura / Amicrobial Pustulosis of the Folds: Report of a New Case and Review of Literature

La pustulosis amicrobiana de las flexuras es una entidad poco frecuente, caracterizada por erupciones formadas por pústulas estériles, de curso recidivante, que afectan a los grandes pliegues cutáneos, cuero cabelludo y áreas periorificiales como el conducto auditivo externo, mayormente. Se han descrito pocos casos en la literatura, la mayoría de ellos en mujeres, y todos ellos asociados a alguna alteración inmunológica, siendo el lupus eritematoso el más frecuente. Presentamos un nuevo caso de esta enfermedad, en una mujer que como única alteración inmunológica presentaba una elevación de la IgE, revisando también los casos descritos en la literatura por el momento (AU)

Amicrobial pustulosis of the folds is a rare disorder characterized by a recurrent sterile pustular rash mainly affecting the skinfolds, scalp, and periorificial regions such as around the external auditory meatus. Few cases have been reported in the literature, most of them occurring women and all of them associated with some immunological disorder, the most common being lupus erythematosus. We present a new case of amicrobial pustulosis of the folds in a woman; the only immunologic abnormality detected was an elevation of immunoglobulin E. We have also reviewed the 35 cases reported in the literature (AU)

[Amicrobial pustulosis of the folds: report of a new case and review of literature]. / Pustulosis amicrobiana de las flexuras. Descripción de un nuevo caso y revisión de la literatura.

Amicrobial pustulosis of the folds is a rare disorder characterized by a recurrent sterile pustular rash mainly affecting the skinfolds, scalp, and periorificial regions such as around the external auditory meatus. Few cases have been reported in the literature, most of them occurring women and all of them associated with some immunological disorder, the most common being lupus erythematosus. We present a new case of amicrobial pustulosis of the folds in a woman; the only immunologic abnormality detected was an elevation of immunoglobulin E. We have also reviewed the 35 cases reported in the literature.

Nail psoriasis: a combined treatment with 8% clobetasol nail lacquer and tacalcitol ointment.

BACKGROUND: Nail involvement is a common and distressing feature in the course of psoriasis. Although much progress has been made in the treatment of the disease, the presence of psoriasis in the nail continues to pose a challenge. In recent years, vitamin D3 analogs and a new formulation containing 8% clobetasol-17-propionate in a colourless nail lacquer vehicle have produced good results for the control of nail psoriasis. OBJECTIVE: To determine the efficacy and safety of the combined treatment of 8% clobetasol-17-propionate in a lacquer vehicle and tacalcitol ointment in nail psoriasis. METHODS: Fifteen patients with both nail bed and nail matrix psoriasis were included in the study. They were treated with a colourless nail lacquer containing 8% clobetasol-17-propionate applied at bedtime at the weekend, and with tacalcitol ointment under occlusion on the remaining days, for 6 months. RESULTS: All 15 patients responded well to treatment. The therapeutic effect was very fast and directly related to the length of therapy. All nail alterations, including nail pain, were reduced, and the modified target Nail Psoriasis Severity Index fell by an average of 78% compared to baseline levels (+/-59.6, P < 0.0001). CONCLUSIONS: Combined treatment with tacalcitol ointment and 8% clobetasol-17-propionate in a nail lacquer is a safe, effective treatment for nail bed and nail matrix psoriasis.