RESUMEN
<b>Background and Objective:</b> The continuous use of pesticides in the ecosystem is of great concern, as some of them are highly stable and impact non-target organisms. The effect was tested of different concentrations of insecticides such as (Deltamethrin and Malathion) and natural products, Including, lemongrass oil on Fruit Fly (<i>Drosophila melanogaster</i>), to calculate the concentration at which the highest mortality occurred and death half the number of individuals after 96 hrs, as well as calculating the half-lethal time for individuals. <b>Materials and Methods:</b> This study, which evaluated the toxicity of five different concentrations (0.75, 1.00, 1.25, 1.50 and 1.75 mg L<sup>1</sup>) of Malathion, (0.05, 0.10, 0.21, 0.53 and 1.48 mg L<sup>1</sup>) of Deltamethrin and lemongrass oil (0.25, 0.50, 0.75, 1.00 and 1.50 mg L<sup>1</sup>) on the insect of <i>Drosophila melanogaster</i> after 96 hrs of treatment. <b>Results:</b> From the results of this study, the concentration (LC<sub>50 </sub>= 2.938 mg L<sup>1</sup>) of Malathion leads to kills half of the individuals, compared to Deltamethrin a higher concentration (LC<sub>50 </sub>= 4.8673 mg L<sup>1</sup>) that leads to killing half of the individuals. While lemongrass oil the concentration (LC<sub>50 </sub>= 9.7478 mg L<sup>1</sup>) leads to kills half of individuals. Also, when used Deltamethrin it takes (LT<sub>50 </sub>= 660.277) hours to kill half of the individuals compared to Malathion, which takes approximately (LT<sub>50</sub> = 321.862) hours to death half of the individuals. But lemongrass oil (LT<sub>50 </sub>= 819.745) hours to kill half of the individuals. <b>Conclusion:</b> In conclusion, the lemon plant and its components have excellent potential for being used in the control of <i>Drosophila melanogaster</i>, which had an effective role in biological control.
