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Eur J Med Chem ; 254: 115378, 2023 Jun 05.
Artículo en Inglés | MEDLINE | ID: mdl-37084599

RESUMEN

A series of thirty 1,2,3-triazolylsterols, inspired by azasterols with proven antiparasitic activity, were prepared by a stereocontrolled synthesis. Ten of these compounds constitute chimeras/hybrids of 22,26-azasterol (AZA) and 1,2,3-triazolyl azasterols. The entire library was assayed against the kinetoplastid parasites Leishmania donovani, Trypanosoma cruzi, and Trypanosoma brucei, the causatives agents for visceral leishmaniasis, Chagas disease, and sleeping sickness, respectively. Most of the compounds were active at submicromolar/nanomolar concentrations with high selectivity index, when compared to their cytotoxicity against mammalian cells. Analysis of in silico physicochemical properties were conducted to rationalize the activities against the neglected tropical disease pathogens. The analogs with selective activity against L. donovani (E4, IC50 0.78 µM), T brucei (E1, IC50 0.12 µM) and T. cruzi (B1- IC50 0.33 µM), and the analogs with broad-spectrum antiparasitic activities against the three kinetoplastid parasites (B1 and B3), may be promising leads for further development as selective or broad-spectrum antiparasitic drugs.


Asunto(s)
Enfermedad de Chagas , Parásitos , Trypanosoma cruzi , Tripanosomiasis Africana , Animales , Esteroles/farmacología , Esteroles/química , Tripanosomiasis Africana/tratamiento farmacológico , Antiparasitarios/química , Enfermedad de Chagas/tratamiento farmacológico , Mamíferos
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