Multimodal transformer graph convolution attention isomorphism network (MTCGAIN): a novel deep network for detection of insomnia disorder.

Background: In clinic, the subjectivity of diagnosing insomnia disorder (ID) often leads to misdiagnosis or missed diagnosis, as ID may have the same symptoms as those of other health problems. Methods: A novel deep network, the multimodal transformer graph convolution attention isomorphism network (MTGCAIN) is proposed in this study. In this network, graph convolution attention (GCA) is first employed to extract the graph features of brain connectivity and achieve good spatial interpretability. Second, the MTGCAIN comprehensively utilizes multiple brain network atlases and a multimodal transformer (MT) to facilitate coded information exchange between the atlases. In this way, MTGCAIN can be used to more effectively identify biomarkers and arrive at accurate diagnoses. Results: The experimental results demonstrated that more accurate and objective diagnosis of ID can be achieved using the MTGCAIN. According to fivefold cross-validation, the accuracy reached 81.29% and the area under the receiver operating characteristic curve (AUC) reached 0.8760. A total of nine brain regions were detected as abnormal, namely right supplementary motor area (SMA.R), right temporal pole: superior temporal gyrus (TPOsup.R), left temporal pole: superior temporal gyrus (TPOsup.L), right superior frontal gyrus, dorsolateral (SFGdor.R), right middle temporal gyrus (MTG.R), left middle temporal gyrus (MTG.L), right inferior temporal gyrus (ITG.R), right median cingulate and paracingulate gyri (DCG.R), left median cingulate and paracingulate gyri (DCG.L). Conclusions: The brain regions in the default mode network (DMN) of patients with ID show significant impairment (occupies four-ninths). In addition, the functional connectivity (FC) between the right middle occipital gyrus and inferior temporal gyrus (ITG) has an obvious correlation with comorbid anxiety (P=0.008) and depression (P=0.005) among patients with ID.

The Expression of P35 Plays a Key Role in the Difference in Apoptosis Induced by AcMNPV Infection in Different Spodoptera exigua Cell Lines.

Baculovirus infection induces apoptosis in host cells, and apoptosis significantly affects virus production. Autographa californica multiple nucleopolyhedrovirus (AcMNPV) can regulate apoptosis, but the regulatory mechanism is unclear. Here, we found that AcMNPV infection induced different apoptosis responses in different Spodoptera exigua cell lines. In the early stages of viral infection (1-6 h), Se-1 cells underwent severe apoptosis, while Se-3 cells underwent very slight apoptosis. In the late stages of viral infection (12-72 h), Se-1 cells continued to undergo apoptosis and formed a large number of apoptotic bodies, while the apoptosis of Se-3 cells was inhibited and no apoptotic bodies were formed. To determine the reasons for the apoptosis differences in the two cell lines, we measured the expression of the six S. exigua cysteine-dependent aspartate specific protease genes (SeCaspase-1 to -6) and the three AcMNPV antiapoptotic protein genes (iap1, iap2 and p35) during viral infection. We found that SeCaspase-1 to -6 were all activated in Se-1 cells and inhibited in Se-3 cells, whereas iap1, iap2 and p35 were all inhibited in Se-1 cells and normally expressed in Se-3 cells. And p35 was expressed earlier than iap1 and iap2 in Se-3 cells. Otherwise, Se-1 and Se-3 cells would all be apoptotic when infected with the recombinant p35 knockout AcMNPV, whereas only Se-1 cells were apoptotic, but Se-3 cells were not apoptotic when infected with the recombinant p35 repair AcMNPV. Combined with the fact that the expression of P35 protein is inhibited in Se-1 cells but normally expressed in Se-3 cells during the infection of recombinant p35 repair AcMNPV, we proposed that the different expression of P35 is an important reason for the apoptosis differences between the two cell lines. We also found that some genes associated with apoptosis can probably regulate the expression of P35. However, the major upstream regulators of P35 and their mechanisms are still unclear and will be studied in the future.

Boosting the Hydrogen Evolution Reaction Performance of P-Doped PtTe2 Nanocages via Spontaneous Defects Formation.

PtTe2 , a member of the noble metal dichalcogenides (NMDs), has aroused great interest in exploring its behavior in the hydrogen evolution reaction (HER) due to the unique type-II topological semimetallic nature. In this work, a simple template-free hydrothermal method to obtain the phosphorus-doped (P-doped) PtTe2 nanocages with abundant amorphous and crystalline interface (A/C-P-PtTe2 ) is developed. Revealed by density functional theory calculations, the atomic Te vacancies can spontaneously form on the basal planes of PtTe2 by the P doping, which results in the unsaturated Pt atoms exposed as the active sites in the amorphous layer for HER. Owing to the defective structure, the A/C-P-PtTe2 catalysts have the fast Tafel step determined kinetics in HER, which contributes to an ultralow overpotential (η = 28 mV at 10 mA cm-2 ) and a small Tafel slope of 37 mV dec-1 . More importantly, benefiting from the inner stable crystalline P-PtTe2 nanosheets, limited decay of the performance is observed after chronopotentiometry test. This work reveals the important role of the inherent relationship between structure and activity in PtTe2 for HER, which may bring another enlightenment for the design of efficient catalysts based on NMDs in the near future.

Toward the High-Performance Lithium Primary Batteries by Chemically Modified Fluorinate Carbon with δ-MnO2.

Li/CFx battery is one of the most promising lithium primary batteries (LPBs) which yields the highest energy density but with poor rate capability. This Achilles'' heel hinders the large-scale applications of Li/CFx batteries. This work first reports a facile chemical modification method of CFx with δ-MnO2 . Having benefited from the chemical bonding, the electrochemical performance at high-rate discharge is remarkably enhanced without compromising the specific capacity. The coin cells exhibit an energy density of 1.94 × 103  Wh kg-1 at 0.2 C, which is approaching the theoretical energy density of commercial fluorinated graphite (2.07 × 103  Wh kg-1 ). A power density of 5.49 × 104  W kg-1 at 40 C associated with an energy density of 4.39 × 102  Wh kg-1 , which is among the highest value of Li/CFx batteries, are obtained. Besides, the punch batteries achieve an ultrahigh power density of 4.39 × 104  W kg-1 with an energy density of 7.60 × 102  Wh kg-1 at 30 C. The intrinsic reasons for this outstanding electrochemical performance, which are known as the fast Li+ diffusion kinetics guided by thin δ-MnO2 flakes and the low formation energy barrier caused by chemical bonding, are explored by the galvanostatic intermittent titration technique (GITT) and theoretical calculations.

Development of Spodoptera exigua Population: Does the Nutritional Status Matter?

Spodoptera exigua (Hübner) is a common agricultural pest that can harm hundreds of crops. Nutrition conditions can significantly affect the development of insects, especially carbohydrates (C) and proteins (P), which are the two most critical nutrients. To study the development of the S. exigua population under different carbohydrate and protein nutrition conditions, we constructed a life table of both sexes of an S. exigua population under three artificial diets: high nitrogen (P:C = 7:1), medium nitrogen, medium sugar (P:C = 1:1), and high sugar (P:C = 1:7). The results showed that the generation time of S. exigua was 26.38 ± 0.54 d under the medium nitrogen-medium sugar diet, which was the shortest among the three nutrition conditions. The intrinsic rate of increase (0.18 ± 0.01), finite rate of increase (1.20 ± 0.01), fecundity (605.42 ± 36.33 eggs/female), and predicted population at 100 days (8,840,000) were significantly higher under the medium nitrogen-medium sugar condition. There was no significant difference in the net reproductive rate among the three conditions. These results suggested that an appropriate protein:carbohydrate ratio is beneficial to the rapid development of S. exigua on farmland. These findings are important for scientifically predicting the population dynamics of S. exigua from the perspective of nutritional ecology, understanding its catastrophic mechanism, and constructing a prevention and control system.