Humidity Adaptive Antifreeze Hydrogel Sensor for Intelligent Control and Human-Computer Interaction.

Conductive hydrogels have emerged as ideal candidate materials for strain sensors due to their signal transduction capability and tissue-like flexibility, resembling human tissues. However, due to the presence of water molecules, hydrogels can experience dehydration and low-temperature freezing, which greatly limits the application scope as sensors. In this study, an ionic co-hybrid hydrogel called PBLL is proposed, which utilizes the amphoteric ion betaine hydrochloride (BH) in conjunction with hydrated lithium chloride (LiCl) thereby achieving the function of humidity adaptive. PBLL hydrogel retains water at low humidity (<50%) and absorbs water from air at high humidity (>50%) over the 17 days of testing. Remarkably, the PBLL hydrogel also exhibits strong anti-freezing properties (-80 °C), high conductivity (8.18 S m-1 at room temperature, 1.9 S m-1 at -80 °C), high gauge factor (GF approaching 5.1). Additionally, PBLL hydrogels exhibit strong inhibitory effects against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), as well as biocompatibility. By synergistically integrating PBLL hydrogel with wireless transmission and Internet of Things (IoT) technologies, this study has accomplished real-time human-computer interaction systems for sports training and rehabilitation evaluation. PBLL hydrogel exhibits significant potential in the fields of medical rehabilitation, artificial intelligence (AI), and the Internet of Things (IoT).

Advances in microfluidic technology for sperm screening and in vitro fertilization.

About 18% of reproductive-age adults worldwide are affected by infertility. In vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are widely used assisted reproductive technologies (ARTs) aimed at improving clinical outcomes. Efficient and noninvasive selection and isolation of highly motile sperm with intact DNA are essential for the success of IVF and ICSI and can potentially impact the therapeutic efficacy and the health of the offspring. Compared to traditional methods, microfluidic technology offers significant advantages such as low sample consumption, high efficiency, minimal damage, high integration, similar microenvironment, and high automation, providing a new platform for ARTs. Here, we review the current situation of microfluidic technology in the field of sperm motility screening and evaluation and IVF research. First, we focus on the working principle, structural design, and screening results of sperm selection microfluidic platforms. We then highlight how the multiple steps of the IVF process can be facilitated and integrated into a microfluidic chip, including oocyte capture, sperm collection and isolation, sperm sorting, fertilization, and embryo culture. Ultimately, we summarize how microfluidics can complement and optimize current sperm sorting and IVF protocols, and challenges and possible solutions are discussed.