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Zebrafish studies on the vaccine candidate to COVID-19, the Spike protein: Production of antibody and adverse reaction

Fernandes, Bianca H. Ventura; Feitosa, Natália Martins; Barbosa, Ana Paula; Bomfim, Camila Gasque; Garnique, Anali M. B.; Gomes, Francisco I. F.; Nakajima, Rafael T.; Belo, Marco A. A.; Eto, Silas Fernandes; Fernandes, Dayanne Carla; Malafaia, Guilherme; Manrique, Wilson G.; Conde, Gabriel; Rosales, Roberta R. C.; Todeschini, Iris; Rivero, Ilo; Llontop, Edgar; G. Sgro, German; Oka, Gabriel Umaji; Bueno, Natalia F.; Ferraris, Fausto K.; Magalhaes, Mariana T. Q. de; Medeiros, Renata J.; Gomes, Juliana M. M.; Junqueira, Mara de Souza; Conceição, Katia; Pontes, Letícia G.; Condino-Neto, Antonio; Perez, Andrea C.; Barcellos, Leonardo J. G.; Correa Junior, Jose Dias; Dorlass, Erick G.; Camara, Niels O. S.; Durigon, Edison Luiz; Cunha, Fernando Q.; Nóbrega, Rafael H.; Machado-Santelli, Glaucia M.; Farah, Chuck; Veras, Flávio P.; Galindo-Villegas, Jorge; Costa-Lotufo, Leticia; Cunha, Thiago M.; Chammas, Roger; Guzzo, Cristiane R.; Carvalho, Luciani R.; Charlie-Silva, Ives.

Preprint en Inglés | Fiocruz Preprints | ID: ppf-45467

Vaccines for COVID-19: perspectives from nucleic acid vaccines to BCG as delivery vector system

Queiroz, Nina Marí G.P. de; Marinho, Fabio V.; Chagas, Marcelo A.; Leite, Luciana Cezar de Cerqueira; Homan, E. Jane; Magalhães, Mariana T.Q. de; Oliveira, Sergio C..

Microbes Infect, v. 22, n. 10, p. 515-524, nov. 2020

Artículo en Inglés | Sec. Est. Saúde SP, SESSP-IBPROD, Sec. Est. Saúde SP | ID: bud-3197

RESUMEN

This article discusses standard and new disruptive strategies in the race to develop an anti-COVID-19 vaccine. We also included new bioinformatic data from our group mapping immunodominant epitopes and structural analysis of the spike protein. Another innovative approach reviewed here is the use of BCG vaccine as priming strategy and/or delivery system expressing SARS-CoV-2 antigens.

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