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2.
Menopause ; 30(5): 545-550, 2023 05 01.
Artículo en Inglés | MEDLINE | ID: mdl-36944142

RESUMEN

OBJECTIVE: This study aimed to evaluate the value of laser acupuncture (LA) on forearm bone mineral density (BMD) and wrist pain in osteoporotic postmenopausal women. METHODS: Sixty-eight postmenopausal women diagnosed with osteoporosis were randomly allocated equally to one of two sets. The drug-only group received calcium and vitamin D 3 supplement containing fluoride daily for 12 weeks, whereas the drug/LA group received LA therapy for 20 minutes per session, three sessions weekly, in addition to the same supplementation. The primary outcome parameter was assessment of BMD of the nondominant arm. Other outcomes included wrist pain. RESULTS: There was a highly significant improvement in the T-score of forearm BMD in both groups (-2.844 ± 0.476 to -2.597 ± 0.478 and -2.944 ± 0.486 to -1.652 ± 0.728 in the drug-only and drug/LA groups, respectively; P < 0.0001) and visual analog scale score (7.50 ± 0.79 to 4.24 ± 1.07 and 7.24 ± 0.82 to 3.09 ± 0.75 in the drug-only and drug/LA group, respectively; P < 0.0001). The improvement of both BMD and pain score was significantly higher in the drug/LA group (-1.303 and 4.15) compared with the drug-only group (-0.247 and 3.26; P < 0.0001). CONCLUSIONS: LA in combination with calcium and vitamin D supplementation containing fluoride is an effective modality in improving forearm BMD and reducing pain in osteoporotic postmenopausal women.


Asunto(s)
Conservadores de la Densidad Ósea , Osteoporosis Posmenopáusica , Femenino , Humanos , Osteoporosis Posmenopáusica/terapia , Fluoruros/farmacología , Calcio , Posmenopausia , Densidad Ósea , Conservadores de la Densidad Ósea/uso terapéutico , Calcio de la Dieta/farmacología , Dolor , Rayos Láser
3.
Eur J Contracept Reprod Health Care ; 28(2): 147-149, 2023 04.
Artículo en Inglés | MEDLINE | ID: mdl-36846948
4.
Reprod Sci ; 25(10): 1509-1514, 2018 10.
Artículo en Inglés | MEDLINE | ID: mdl-29439618

RESUMEN

OBJECTIVE: To evaluate the effect of prolonged Gonadotropin releasing hormone (GnRH) agonist downregulation in patients with endometriomas of less than 5 cm on the outcome of the proceeding Intracytoplasmic sperm injection (ICSI) trial. METHODS: In a randomized controlled trial at a university teaching hospital, 90 patients indicated for ICSI and having unilateral single endometrioma of less than 5 cm in diameter were randomized into 2 groups. Group A (45 patients) received the standard long protocol; whereas group B (45 patients) received 3 consecutive Intramuscular (IM) injections of triptorelin 3.75 mg 28 days apart followed by the standard long protocol 28 days after the last injection. RESULTS: There were no significant differences in the clinical and hormonal characteristics between the 2 groups. All ICSI cycle characteristics including number of retrieved oocytes, fertilized oocytes, and transferred embryos were also not significantly different. However, patients who received prolonged GnRH agonist therapy showed significantly higher chemical ( P = .011), clinical ( P = .018), and ongoing ( P = .028) pregnancy rates. CONCLUSION: Prolonged GnRH agonist downregulation improves the pregnancy rates in patients with small endometriomas undergoing ICSI.


Asunto(s)
Endometriosis/patología , Hormona Liberadora de Gonadotropina/agonistas , Resultado del Embarazo , Inyecciones de Esperma Intracitoplasmáticas , Adulto , Regulación hacia Abajo , Transferencia de Embrión , Endometriosis/complicaciones , Femenino , Humanos , Recuperación del Oocito , Embarazo , Índice de Embarazo , Resultado del Tratamiento , Pamoato de Triptorelina/administración & dosificación
5.
Arch Gynecol Obstet ; 297(4): 951-959, 2018 04.
Artículo en Inglés | MEDLINE | ID: mdl-29350276

RESUMEN

OBJECTIVE: To study the effectiveness of performing swimming on the severity of symptoms of premenstrual syndrome (PMS). MATERIALS AND METHODS: A randomized controlled trial that was conducted on 70 women diagnosed with PMS divided randomly into two equal groups: Group I included women who engaged into exercise and group II controls. Daily Symptoms Report was filled at the start and at end of the study. RESULTS: At the posttreatment evaluation, there was a highly significant difference between the study and control groups regarding anxiety (0 vs. 5), depression (3 vs. 12), tension (3 vs. 12), mood changes (0 vs. 7), feeling out of control (0 vs. 7), weak coordination (0 vs. 10), confusion (2 vs. 9), headache (3 vs. 15), tiredness (4 vs. 12), pains (5 vs. 11), tenderness of the breast (2 vs. 8), and cramps (6 vs. 17) (P < 0.001), but no such difference was found regarding irritability, insomnia, crying, swelling, or food craving. Regarding the percentage of symptoms changes, there was a highly significant difference between the study and control groups regarding anxiety (- 33.3 vs. 0), depression (- 79.29 vs. 15.56), tension (- 81.18 vs. - 6.79), mood changes (- 33.33 vs. 0), feeling out of control (- 91.67 vs. 0), weak coordination (- 100 vs. - 9.55), sleeplessness (- 71.43 vs. 0), confusion (- 84.17 vs. - 9.55), headache (- 77.78 vs. - 6.94), fatigue (- 65.69 vs. 0), pains (- 65.83 vs. - 8.93), breast tenderness (- 87.87 vs. 4.55), cramps (- 60.77 vs. 4.55), and swellings (- 55.05 vs. - 8.33), but no such difference was found regarding irritability, crying, or food craving. CONCLUSIONS: There is beneficial effect of swimming on most of the physical and psychological symptoms of PMS. CLINICAL TRIAL REGISTRY NO: NCT03264612.


Asunto(s)
Terapia por Ejercicio/métodos , Ejercicio Físico , Síndrome Premenstrual/terapia , Natación , Adulto , Ansiedad/terapia , Depresión/terapia , Ejercicio Físico/fisiología , Ejercicio Físico/psicología , Fatiga , Femenino , Cefalea/terapia , Humanos , Ciclo Menstrual/fisiología , Ciclo Menstrual/psicología , Trastornos del Inicio y del Mantenimiento del Sueño , Trastornos del Sueño-Vigilia/terapia , Natación/fisiología , Natación/psicología
6.
J Matern Fetal Neonatal Med ; 31(22): 2959-2964, 2018 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-28738708

RESUMEN

OBJECTIVE: To assess the effect of hyoscine butylbromide (HBB) on duration of the first stage of labor in primigravdae. METHODS: A case-control study conducted on 120 primigravida at term admitted in active labor were divided into three equal groups. A single dose of the drug (placebo or HBB 20 mg or HBB 40 mg) was injected intravenously slowly to groups A, B, and C. The duration of the first stage was calculated from the time of cervical dilatation of three to four centimeters in active labor until a fully dilated cervix was observed. RESULTS: The duration of first stage was significantly shorter in women receiving 20 and 40 mg of HBB when controlled to control women (187.73 ± 20.92, 186.41 ± 19.40 versus 231.39 ± 33.14 min). There was no significant difference between the three study groups regarding duration of the second stage (36.76 ± 9.98, 35.72 ± 9.97 and 37.55 ± 10.57, respectively, p > .05), number of cases delivered by cesarean section (12.5%, 12.5%, and 15%, respectively, p > .05) and Apgar score of the neonates (p > .05). There was no significant difference between the three study groups regarding occurrence of side effects named dry mouth (7.5%, 12.5%, and 5%, p > .05), flushing (2.5%, 5% and 0%, p > .05), tachycardia (2.5%, 2.5%, and 2.5%, p > .05), or urinary retention (2.5%, 0%, and 0%, p > .05). CONCLUSION: Intravenous injection of HBB decreases the duration of active phase of labor in primigravidae with no side effects.


Asunto(s)
Bromuro de Butilescopolamonio/farmacología , Primer Periodo del Trabajo de Parto/efectos de los fármacos , Parasimpatolíticos/farmacología , Adulto , Estudios de Casos y Controles , Método Doble Ciego , Femenino , Número de Embarazos , Humanos , Embarazo , Estudios Prospectivos , Adulto Joven
8.
J Assist Reprod Genet ; 34(12): 1659-1666, 2017 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-28825151

RESUMEN

OBJECTIVE: The aim of this study is to assess the role of AMH in prediction of poor ovarian response as well as the relation between ESR 2 (+ 1730G>A) (rs4986938) and FSHR p.Thr307Ala (c.919A>G, rs6165) SNPs and the poor ovarian response in Egyptian women undergoing IVF procedure. Discovering the genetic variants associated with ovarian response is an important step towards individualized pharmacogenetic protocols of ovarian stimulation. METHODS: We performed a prospective study on 216 young women with unexplained infertility. Ovarian stimulation was performed according to the GnRH antagonist protocol with a fixed daily morning dose of human menopausal gonadotrophin (HMG). The estrogen receptor (ESR2) (+ 1730G>A) (rs4986938) and FSH receptor p.Thr307Ala (c.919A>G, rs6165) single nucleotide polymorphisms (SNPs) were detected by real-time polymerase chain reaction. Serum FSH, Estradiol (E2) and anti-Müllerian hormone (AMH) levels were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: This study revealed that the low AMH level was highly significantly related to the poor ovarian response (p < 0.001). Furthermore, the frequency of the ESR2 (AA) genotype and the FSHR (Ala307Ala) genotypes were highly significantly associated with the poor ovarian response (p < 0.001). CONCLUSION: The AMH level in combination with the ESR2 and the FSHR gene polymorphisms predict the poor ovarian response to COH in Egyptian women. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02640976.


Asunto(s)
Hormona Antimülleriana/sangre , Receptor beta de Estrógeno/genética , Fertilización In Vitro/métodos , Infertilidad Femenina/fisiopatología , Inducción de la Ovulación , Polimorfismo de Nucleótido Simple , Receptores de HFE/genética , Adulto , Egipto , Estradiol/sangre , Femenino , Hormona Folículo Estimulante/sangre , Genotipo , Hormona Liberadora de Gonadotropina/antagonistas & inhibidores , Antagonistas de Hormonas/uso terapéutico , Humanos , Infertilidad Femenina/tratamiento farmacológico , Embarazo , Índice de Embarazo , Estudios Prospectivos
9.
J Matern Fetal Neonatal Med ; 29(4): 532-6, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-25731657

RESUMEN

OBJECTIVE: To compare effectiveness and tolerability of carbetocin versus oxytocin in prevention of postpartum hemorrhage (PPH) after vaginal delivery. METHODS: A prospective double-blinded randomized study conducted on 200 pregnant women randomized into two groups: Group 1 (100 women) received single 100 µg IM dose of carbetocin and Group 2 received of 5 IU oxytocin IM. Both groups received their drug after fetal and before placental delivery. RESULTS: There was a statistically significant difference between the two study groups regarding amount of bleeding (337.73 ± 118.77 versus 378 ± 143.2), occurrence of PPH (4 versus 16%), need for other uterotonics (23 versus 37%) and hemoglobin difference between before and after delivery (0.55 ± 0.35 versus 0.96 ± 0.62) (all being lower in carbetocin group) and measured hemoglobin 24 h after delivery (being higher in carbetocin group); however, there was no significant difference between the two study groups regarding occurrence of major PPH and the need for blood transfusion. Women in carbetocin group showed a statistically significant lower systolic and diastolic blood pressure immediately after delivery and at 30 and 60 min than women in oxytocin group. There was no significant difference between the two study groups regarding occurrence of nausea, vomiting, flushing, dizziness, headache, shivering, metallic taste, dyspnea, palpitation and itching. Women in carbetocin group experienced tachycardia more than women in oxytocin group. CONCLUSIONS: Carbitocin is a better alternative to traditional oxytocin in prevention of PPH after vaginal delivery with minimal hemodynamic changes and similar side effects.


Asunto(s)
Oxitócicos/uso terapéutico , Oxitocina/análogos & derivados , Oxitocina/uso terapéutico , Hemorragia Posparto/prevención & control , Adulto , Presión Sanguínea , Parto Obstétrico , Método Doble Ciego , Femenino , Hemoglobinas/análisis , Humanos , Embarazo , Estudios Prospectivos , Taquicardia/inducido químicamente
10.
Arch Gynecol Obstet ; 293(5): 993-9, 2016 May.
Artículo en Inglés | MEDLINE | ID: mdl-26511939

RESUMEN

OBJECTIVE: The objective of this study is to compare the effectiveness and safety of carbetocin vs. oxytocin in the management of atonic post partum haemorrhage (PPH) after vaginal delivery. METHODS: A prospective randomised study was conducted in which 100 pregnant women were randomised into 2 equal groups: group 1 received Carbetocin 100 µgm (Pabal(®) Ferring, UK) and group 2 received oxytocin 5 IU (Syntocinon(®), Novartis, Switzerland). RESULTS: The amount of blood loss and the need for other uterotonics were significantly lower in the carbetocin group (811 ± 389.17 vs. 1010 ± 525.66 and 10/50 vs. 21/50). There was no significant difference between the carbetocin and oxytocin groups regarding occurrence of major PPH (6 vs. 11), the need for blood transfusion (6 vs. 9), the difference between blood haemoglobin levels before delivery and 24 h after delivery (0.6 ± 0.28 vs. 0.56 ± 0.25), respectively. There was no significant difference between the 2 study groups regarding both systolic and diastolic blood pressure measured immediately after the drug administration and at 30 and 60 min later. Regarding the drugs side effects, there was no significant difference between the 2 groups in the occurrence of nausea, vomiting, tachycardia, flushing, dizziness, headache, shivering, metallic taste, dyspnea, palpitations and itching. CONCLUSIONS: Carbetocin is a better alternative to oxytocin in management of atonic PPH with non-significant hemodynamic changes or side effects .


Asunto(s)
Parto Obstétrico/métodos , Oxitocina/análogos & derivados , Oxitocina/uso terapéutico , Hemorragia Posparto/tratamiento farmacológico , Adulto , Presión Sanguínea , Mareo/inducido químicamente , Método Doble Ciego , Femenino , Cefalea/etiología , Humanos , Náusea/inducido químicamente , Oxitócicos/efectos adversos , Oxitócicos/uso terapéutico , Oxitocina/efectos adversos , Hemorragia Posparto/etiología , Embarazo , Estudios Prospectivos , Suiza , Resultado del Tratamiento , Vértigo/tratamiento farmacológico , Vómitos/inducido químicamente
11.
J Matern Fetal Neonatal Med ; 27(11): 1108-12, 2014 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-24090161

RESUMEN

OBJECTIVE: To study various biomarkers in prediction of gestational diabetes mellitus (GDM). PATIENTS AND METHODS: Prospective observational study included 400 pregnant women. Maternal serum sex hormone binding globulin (SHBG), high-sensitive C-reactive protein (hs-CRP), uric acid, creatinine and albumin were measured before 15 weeks of gestation. Patients were followed-up for development of GDM. RESULTS: A total of 269 women were eligible for analysis. GDM complicated 27 (10.03%) of pregnancies. Hs-CRP levels were significantly higher and SHBG levels were significantly lower among women who subsequently developed GDM compared with normoglycemics. Uric acid, albumin and creatinine levels were not significantly different between both groups. For prediction of GDM, hs-CRP at a cutoff value of 2.55 mg/l showed a sensitivity and a specificity of 89% and 55%, respectively. SHBG at a cutoff value of 211.5 nmol/l showed a sensitivity and a specificity of 85% and 37%, respectively. Low SHBG with high hs-CRP predicted GDM with a sensitivity and specificity of 74.07% and 75.62%, respectively with an overall accuracy of 75.46%. CONCLUSION: Hs-CRP and SHBG are important early predictors of GDM. Adding SHBG to hs-CRP improves specificity and serves good overall accuracy. Uric acid, creatinine and albumin have no role in GDM prediction.


Asunto(s)
Biomarcadores/sangre , Diabetes Gestacional/diagnóstico , Diagnóstico Prenatal/métodos , Adulto , Albúminas/análisis , Proteína C-Reactiva/análisis , Creatinina/sangre , Diabetes Gestacional/sangre , Diagnóstico Precoz , Femenino , Humanos , Embarazo , Sensibilidad y Especificidad , Globulina de Unión a Hormona Sexual/análisis , Ácido Úrico/sangre , Adulto Joven
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