RESUMEN
The European Early Lung Cancer (EUELC) project aims to determine if specific genetic alterations occurring in lung carcinogenesis are detectable in the respiratory epithelium. In order to pursue this objective, nonsmall cell lung cancer (NSCLC) patients with a very high risk of developing progressive lung cancer were recruited from 12 centres in eight European countries: France, Germany, southern Ireland, Italy, the Netherlands, Poland, Spain and the UK. In addition, NSCLC patients were followed up every 6 months for 36 months. A European Bronchial Tissue Bank was set up at the University of Liverpool (Liverpool, UK) to optimise the use of biological specimens. The molecular-pathological investigations were subdivided into specific work packages that were delivered by EUELC Partners. The work packages encompassed mutational analysis, genetic instability, methylation profiling, expression profiling utilising immunohistochemistry and chip-based technologies, as well as in-depth analysis of FHIT and RARbeta genes, the telomerase catalytic subunit hTERT and genotyping of susceptibility genes in specific pathways. The EUELC project engendered a tremendous collaborative effort, and it enabled the EUELC Partners to establish protocols for assessing molecular biomarkers in early lung cancer with the view to using such biomarkers for early diagnosis and as intermediate end-points in future chemopreventive programmes.
Asunto(s)
Carcinoma de Pulmón de Células no Pequeñas/diagnóstico , Neoplasias Pulmonares/diagnóstico , Anciano , Carcinoma de Pulmón de Células no Pequeñas/metabolismo , Metilación de ADN , Análisis Mutacional de ADN , Epitelio/metabolismo , Europa (Continente) , Femenino , Humanos , Inmunohistoquímica/métodos , Neoplasias Pulmonares/metabolismo , Masculino , Persona de Mediana Edad , Análisis de Secuencia por Matrices de Oligonucleótidos , Receptores de Ácido Retinoico/metabolismo , Telomerasa/metabolismoRESUMEN
Bronchiolitis obliterans organizing pneumonia (BOOP) presents with fever, dyspnoea, pleuritic chest pain and hypoxia. The diagnosis can be made from radiological appearances on chest radiograph and CT scan correlated with histological findings following biopsy. We present a 52-year-old gentleman undergoing treatment for high grade non-Hodgkin's lymphoma who developed respiratory symptoms during chemotherapy. BOOP was diagnosed and he responded well to oral prednisolone. The cause of BOOP is often not certain. However, in this case we suspect pegylated filgrastim or rituximab as possible agents.
Asunto(s)
Anticuerpos Monoclonales/efectos adversos , Anticuerpos Monoclonales/uso terapéutico , Neumonía en Organización Criptogénica/inducido químicamente , Factor Estimulante de Colonias de Granulocitos/efectos adversos , Factor Estimulante de Colonias de Granulocitos/uso terapéutico , Linfoma no Hodgkin/complicaciones , Linfoma no Hodgkin/terapia , Anticuerpos Monoclonales de Origen Murino , Biopsia , Neumonía en Organización Criptogénica/diagnóstico por imagen , Neumonía en Organización Criptogénica/etiología , Neumonía en Organización Criptogénica/patología , Ciclofosfamida/uso terapéutico , Doxorrubicina/uso terapéutico , Quimioterapia Combinada , Filgrastim , Humanos , Inmunoterapia , Linfoma no Hodgkin/inmunología , Linfoma no Hodgkin/patología , Masculino , Persona de Mediana Edad , Polietilenglicoles , Prednisolona/uso terapéutico , Radiografía , Proteínas Recombinantes , Rituximab , Tomógrafos Computarizados por Rayos X , Vincristina/uso terapéuticoRESUMEN
Using quantum molecular dynamics simulations, we show that the optical properties of aluminum change drastically along the nonmetal metal transition observed experimentally. As the density increases and the many-body effects become important, the optical response gradually evolves from the one characteristic of an atomic fluid to the one of a simple metal. We show that quantum molecular dynamics combined with the Kubo-Greenwood formulation naturally embodies the two limits and provides a powerful tool to calculate and benchmark the optical properties of various systems as they evolve into the warm dense matter regime.
