Dynamics and immunomodulation of cognitive deficits and behavioral changes in non-severe experimental malaria.

Data recently reported by our group indicate that stimulation with a pool of immunogens capable of eliciting type 2 immune responses can restore the cognitive and behavioral dysfunctions recorded after a single episode of non-severe rodent malaria caused by Plasmodium berghei ANKA. Here we explored the hypothesis that isolated immunization with one of the type 2 immune response-inducing immunogens, the human diphtheria-tetanus (dT) vaccine, may revert damages associated with malaria. To investigate this possibility, we studied the dynamics of cognitive deficits and anxiety-like phenotype following non-severe experimental malaria and evaluated the effects of immunization with both dT and of a pool of type 2 immune stimuli in reversing these impairments. Locomotor activity and long-term memory deficits were assessed through the open field test (OFT) and novel object recognition task (NORT), while the anxiety-like phenotype was assessed by OFT and light/dark task (LDT). Our results indicate that poor performance in cognitive-behavioral tests can be detected as early as the 12th day after the end of antimalarial treatment with chloroquine and may persist for up to 155 days post infection. The single immunization strategy with the human dT vaccine showed promise in reversal of long-term memory deficits in NORT, and anxiety-like behavior in OFT and LDT.

Feeding of children with tracheostomy at hospital discharge / Forma de alimentação de crianças com traqueostomia na alta hospitalar

ABSTRACT Purpose: to describe the work of speech-language-hearing therapists and verify which was the most prevalent feeding method in the sample studied. Methods: a descriptive observational study based on data surveyed from medical records. The following variables were used: age, medical diagnosis, hospital ward, feeding method before and after the tracheostomy, time of speech-language-hearing care, and speech-language-hearing discharge. The data were submitted to descriptive statistical analysis with the appropriate tests to compare the categorical variables. All infants and children with tracheostomy performed either before or during hospital stay between July 2017 and July 2018, who received speech-language-hearing care upon request of the physician, were included. Results: a total of 51 children took part in the study, most of whom were males (56.9%), with a median age of 12 months, ranging from 1 month to 12 years old at the time of the speech-language-hearing assessment. The feeding methods at hospital discharge were described as follows: full oral feeding (37%), partial oral feeding (25.5%), nasogastric/nasoenteral tube (19.6%), and gastrostomy (17.6%). Conclusion: the full oral diet of tracheostomized children was the most prevalent feeding method at hospital speech-language-hearing discharge.

RESUMO Objetivo: descrever o trabalho fonoaudiológico e verificar qual forma de alimentação foi mais prevalente dentro da amostra estudada. Métodos: trata-se de um estudo observacional descritivo, realizado por meio de levantamento de dados nos prontuários, onde buscou-se as seguintes variáveis: idade, diagnóstico médico, setor de internação, forma de alimentação antes e após traqueostomia, período de atendimento fonoaudiológico e alta fonoaudiológica. Os dados foram submetidos à análise estatística descritiva, tendo sido utilizados testes pertinetes para a comparação de variáveis categóricas. Foram incluídos no estudo todos os lactentes e crianças traqueostomizadas com traqueostomia prévias ou realizadas durante internação, no período de julho de 2017 a julho de 2018, que receberam atendimento fonoaudiológico mediante solicitação médica. Resultados: cinquenta e uma crianças foram incluídas no estudo. A maioria das crianças era do sexo masculino (56,9%) e a idade mediana foi de 12 meses, com variação de 01 mês de vida a 12 anos de idade, no momento da avaliação fonoaudiológica. A forma de alimentação na alta fonoaudiológica hospitalar foi descrita em: via oral exclusiva (37%), via oral parcial (25,5%), sonda nasogástrica/nasoenteral (19,6%) e gastrostomia (17,6%). Conclusão: foi possível observar que a dieta por via oral de maneira exclusiva foi a forma de alimentação de maior prevalência na alta fonoaudiológica hospitalar.

The role of Angiology and Vascular Surgery in the COVID-19 pandemic.

The New Coronavirus Epidemic (2019-nCoV), discovered in the city of Wuhan, China, in December 2019, presents mainly with pulmonary pneumonia that is preceded by fever, cough and myalgia. However, as the disease spread globally and the number of hospitalizations increased exponentially, it was noted that most serious patients hospitalized by COVID-19 have laboratory changes worthy of attention, such as lymphopenia, neutrophilia, increased time of prothrombin and increased levels of D-dimer. Due to these changes proving to be crucial for the mortality and morbidity rates in this subset of infected people, several studies focusing on the pathophysiology, mainly hematological, of the disease appear every day. Deepening these studies, several published works have shown SarsCoV-2 infection to the installation of a prothrombotic state in hospitalized patients, which leads to the potential occurrence of thrombotic or arterial events in this cohort. Thus, in order to understand how the departments of Angiology and Vascular Surgery are acting in the context of the COVID-19 pandemic, this work aims to gather studies that reveal from protocols applied in vascular services in the current situation, until to the role of vascular surgeons and angiologists in the clinical and surgical management of patients infected or not, as a way of helping and clarifying this specialty during the context of a pandemic due to the new coranavirus. For the selection of works, the following search criteria were used: "Coronavirus and venous thrombosis", "Coronavirus and thrombosis", "COVID-19 and venous thrombosis" and "COVID-19 Coronavirus and thrombosis".

The role of Angiology and Vascular Surgery in the COVID-19 pandemic / A atuação da Angiologia e da Cirurgia Vascular na pandemia de COVID-19

ABSTRACT The New Coronavirus Epidemic (2019-nCoV), discovered in the city of Wuhan, China, in December 2019, presents mainly with pulmonary pneumonia that is preceded by fever, cough and myalgia. However, as the disease spread globally and the number of hospitalizations increased exponentially, it was noted that most serious patients hospitalized by COVID-19 have laboratory changes worthy of attention, such as lymphopenia, neutrophilia, increased time of prothrombin and increased levels of D-dimer. Due to these changes proving to be crucial for the mortality and morbidity rates in this subset of infected people, several studies focusing on the pathophysiology, mainly hematological, of the disease appear every day. Deepening these studies, several published works have shown SarsCoV-2 infection to the installation of a prothrombotic state in hospitalized patients, which leads to the potential occurrence of thrombotic or arterial events in this cohort. Thus, in order to understand how the departments of Angiology and Vascular Surgery are acting in the context of the COVID-19 pandemic, this work aims to gather studies that reveal from protocols applied in vascular services in the current situation, until to the role of vascular surgeons and angiologists in the clinical and surgical management of patients infected or not, as a way of helping and clarifying this specialty during the context of a pandemic due to the new coranavirus. For the selection of works, the following search criteria were used: "Coronavirus and venous thrombosis", "Coronavirus and thrombosis", "COVID-19 and venous thrombosis" and "COVID-19 Coronavirus and thrombosis".

RESUMO A epidemia pelo novo Coronavirus (2019-nCoV), surgido na cidade de Wuhan, na China, em dezembro de 2019, quando sintomática, apresenta-se majoritariamente por um quadro de pneumonia pulmonar que é precedida por febre, tosse seca e mialgia. No entanto, conforme a doença se espalhou globalmente e o número de hospitalizações aumentaram de forma exponencial, notou-se que a maior parte dos pacientes graves internados por COVID-19 possuem alterações laboratoriais dignas de atenção, como linfopenia, neutrofilia, aumento do tempo de protrombina e elevação dos níveis de D-dímero. Devido tais mudanças se mostrarem cruciais para a taxa de mortalidade e morbidade nesse subgrupo de infectados, diversos trabalhos com enfoque na fisiopatologia, principalmente hematológica, da doença surgem a cada dia. Aprofundando em tais estudos, variados trabalhos publicados evidenciaram a infecção pelo Sars-CoV-2 à instalação de um estado pró-trombótico em pacientes hospitalizados graves, o que acarreta em potencial ocorrência de eventos trombóticos venosos ou arteriais nessa coorte. Assim, para entender como os Departamentos de Angiologia e Cirurgia Vascular estão atuando no contexto da pandemia de COVID-19, este estudo tem por objetivo reunir estudos que revelam desde protocolos aplicados nos serviços vasculares na atual conjuntura, até a atuação dos cirurgiões vasculares e angiologistas no manejo clínico e cirúrgico de pacientes infectados ou não, como forma de ajudar e esclarecer essa especialidade durante o contexto de pandemia pelo novo coronavírus. Para a seleção dos trabalhos foram utilizados os seguintes critérios de busca: "Coronavirus and venous thrombosis", "Coronavirus and thrombosis", "COVID-19 and venous thrombosis" e "COVID-19 Coronavirus and thrombosis".

Breastfeeding rate and speech-language therapy in the Kangaroo Method / Índice de aleitamento materno e atuação fonoaudiológica no Método Canguru

ABSTRACT Purpose: to verify the hospital discharge rate in breastfeeding and speech-language practice during implementation of the kangaroo method in a tertiary-level teaching hospital. Methods: a retrospective and documentary study, whose data were collected from electronic medical records of all preterm and/or low birth weight newborns, born at or admitted to a teaching hospital, from August 2016 to August 2017, and who had received care by the speech-language team. Data were collected regarding sample characterization (gender, Apgar, gestational age, birth weight, and orotracheal intubation time); speech-language therapy time; description of the procedures used, such as weight to start breastfeeding, empty breast technique, translactation, and feeding method at the time of speech-language therapy and hospital discharge. Appropriate statistical tests were applied, adopting a significance level lower than 0.05%. Results: there was a higher rate of breastfeeding in moderately preterm infants, born in a gestational age of 30 to 34 weeks, and in low birth weight newborns. Conclusion: breastfeeding was the prevalent feeding method for newborns. The results show that the speech-language stimulation of newborns was adapted from the conventional model to that proposed by the Kangaroo Method, corroborating with humanized care guidelines.

RESUMO Objetivo: verificar o índice de alta hospitalar em aleitamento materno e a atuação fonoaudiológica no período de implantação do Método Canguru em um hospital escola de nível terciário. Métodos: estudo retrospectivo, documental, com coleta de dados dos prontuários eletrônicos de todos os recém-nascidos pré-termo e/ou baixo peso, nascidos ou admitidos no período de agosto de 2016 a agosto de 2017, em um hospital escola, e atendidos pela equipe de fonoaudiologia. Foram coletados dados como caracterização da amostra (gênero, APGAR, idade gestacional, peso ao nascimento, período de intubação orotraqueal), período de atendimento fonoaudiológico, descrição das condutas utilizadas, tais como o peso para início ao aleitamento materno, técnica de "mama esvaziada", translactação e forma de alimentação no momento da alta fonoaudiológica e hospitalar. Foram aplicados os testes estatísticos adotando-se o nível de significância menor que 0,05. Resultados: houve maior índice de aleitamento materno nos prematuros moderados, nascidos com idade gestacional de 30 a 34 semanas e nos recém-nascidos de baixo peso. Conclusão: o aleitamento materno foi a forma de alimentação prevalente dos recém-nascidos. Os resultados mostram que a estimulação fonoaudiológica dos recém-nascidos foi adaptada do modelo convencional para o modelo proposto pelo Método Canguru e apresentou concordância com as orientações do atendimento humanizado.