Low handgrip strength is related to elevated echogenicity in patients with chronic kidney disease: A pilot, cross-sectional and exploratory study.

OBJECTIVES: Evaluate associations between triceps braqui muscle ultrasound measures (TB US) and handgrip strength (HGS), and the sensibility of TB US for low HGS in non-dialysis-dependent chronic kidney disease (nd-CKD) patients. PARTICIPANTS AND METHODS: This pilot, cross-sectional, and exploratory study evaluated TB cross-sectional images from A-mode US and processed by FIJI-Image J to obtain muscle thickness (MT), echogenicity (EI), cross-sectional area (CSA), pennation angle (PA), and fascicle length (Lf) associating them with absolute HGS by simple and, multiple linear regression. The HGS was normalized to body mass index (BMI) and separated into low HGS (HGS/BMI≤10p according to sex and age) and adequate HGS (HGS/BMI>10p) groups. The body composition was from multifrequency bioimpedance. ROC analysis verified the TB US diagnostic accuracy to low HGS. RESULTS: Were included 42 (21M/21F) adults with 65.5 (60-70) y median age, 47.22% in 3b CKD stage. The low HGS group (45.23%) showed a higher fat mass (FM), TB muscle medium head's PA, and EI than adequate HGS (p<0.05). In crude model, a pixels increase in EI was associated with a 0.452kgf HGS reduction (p=0.019); adjusted for sex, age, and FM, a one-unit increase in EI was associated with a 0.510kgf HGS reduction (p=0.011). The EI also showed moderate diagnostic accuracy (AUC=0.730; CI 95%=0.589; 0.919) to low HGS and a sensitivity of 86.9% (cutoff≥13.52 pixels). CONCLUSION: In nd-CKD patients, of all measurements from US, the EI was the most associated with HGS, and the only one sensitive to low HGS diagnosis.

Association of SARC-F and dissociation of SARC-F + calf circumference with comorbidities in older hospitalized cancer patients.

The Strength, Assistance for walking, Rise from a chair, Climb stairs and Falls (SARC-F) score is a tool recommended for screening the risk of sarcopenia in older patients. However, the association between SARC-F or SARC-F + calf circumference (SARC-F + CC) and the Charlson Comorbidity Index (CCI) in hospitalized older cancer patients is not fully understood. Thus, our aim is to evaluate the association between the SARC-F or SARC-F + CC and the presence of comorbidities and risk of death in older hospitalized cancer patients. A cross-sectional study involving 90 (42 M/48F) hospitalized cancer patients over 60 years old with ongoing chemotherapy or surgical treatment is carried out. The SARC-F is performed to assess the muscle function loss (MFL if SARC-F ≥ 4), sarcopenia (SARC-F ≥ 6) and sarcopenia using the calf circumference (SARC-F + CC ≥11). CC is assessed using an inelastic tape. The CCI is used to assess the presence of comorbidities. Logistic regression is used to evaluate the association between the SARC-F and Charlson Comorbidity Index. Mean of age is 67.8 years and half (49%) of the patients present MFL (SARC-F ≥ 4), 31% present sarcopenia using the SARC-F ≥ 6 and 60% using the SARC-F + calf circumference ≥ 11. Although no association in the crude model, there is association after adjusting by age, sex, alcohol use, smoking habit, physical activity, use of oral nutritional supplementation, body mass index, performance status, tumor, and treatment type between SARC-F ≥ 4 or ≥ 6 and CCI (SARC-F ≥ 4 × CCI: OR: 2.31 [95%CI: 1.02-5.23], p = 0.04) and (SARC-F ≥ 6 × CCI: OR: 3.24 [95%CI: 1.21-8.65], p = 0.01), respectively. However, this association is lost when using the SARC-F + calf circumference (SARC-F + CC ≥11 × CCI: OR: 1.12 [95%CI: 0.63-1.90], p = 0.68). In conclusion, screening for the risk of sarcopenia in older cancer patients is highly recommended as sarcopenia is tightly associated with the clinical outcome. The use of the SARC-F score using a cut-off ≥4 or ≥ 6 is more relevant for clinical practice to detect comorbidities and risk of death than the use of SARC-F with the calf circumference.

The neutrophil-to-lymphocyte ratio is inversely associated with adductor pollicis muscle thickness in older patients with gastrointestinal tract cancer.

OBJECTIVES: The neutrophil-to-lymphocyte ratio (NLR) is considered a systemic inflammatory marker and has been associated with a poor prognosis in various cancer types. The aim of this study was to assess whether lower NLR values are associated with higher adductor pollicis muscle thickness (APMT) values in patients with gastrointestinal tract cancer. METHODS: A cross-sectional study assessed 99 patients with digestive system cancers. Tumor stage was analyzed by a physician. Body mass index (BMI; kg/m2) was calculated using the body weight (kg) divided by the height (m) squared; APMT (mm) using a skinfold caliper; handgrip strength (kg) using a dynamometer; calf circumference (cm) using an inelastic tape; gait speed using a distance of four meters to walk (m/s); and habitual food intake using 24-h food recall. Systemic inflammation was measured using the NLR. NLR values of ≥5.0 were considered high inflammation and <5.0 was the reference value. RESULTS: The NLR ≥ 5.0 group presented higher systemic inflammation compared with the NLR < 5.0 group (NLR ≥ 5.0; 11.7 ± 7.7 vs NLR < 5.0; 8.8 ± 4.5; P = 0.0001). Age, sex, tumor stage, body weight, BMI, calf circumference, handgrip strength, and gait speed were not significantly different among the groups (P > 0.05). Additionally, the NLR ≥ 5.0 group presented lower APMT values than the NLR < 5.0 group (NLR ≥ 5.0; 6.3 ± 2.4 mm vs NLR < 5.0; 2.1 ± 1.2 mm; P = 0.002). NLR values were inversely associated with APMT in the crude model (odds ratio: 0.84; range, 0.71-0.98; P = 0.03) and when adjusted by age, BMI, and protein intake (odds ratio: 0.83; range, 0.70-0.98; P = 0.03). CONCLUSIONS: In patients with cancer, NLR is negatively associated with APMT.