1.
J Ind Microbiol
; 15(1): 5-9, 1995 Jul.
Artículo
en Inglés
| MEDLINE
| ID: mdl-7662298
RESUMEN
Fermentation conditions are described for the production of the antitumor antibiotic 7-(S)-brefeldin-A (brefeldin-A) in liquid culture by Eupenicillium brefeldianum, (B.Dodge) Stolk and Scott, ATCC 58665. An analytical hplc method was developed which allowed rapid quantitation of the compound during fermentation. A kilogram of brefeldin-A was isolated from a fermentation at the 6800-liter scale.