1.
Bioorg Med Chem
; 17(23): 8073-85, 2009 Dec 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19853459
RESUMEN
A series of 2'-hydroxy-chalcones and their oxidative cyclization products, aurones, have been synthesized and tested for their antioxidant and lipoxygenase inhibitory activity. The natural product aureusidin (31) was synthesized in high yield by a new approach. An extensive structure-relationship study was performed and revealed that several chalcones and aurones possess an appealing pharmacological profile combining high antioxidant and lipid peroxidation activity with potent soybean LOX inhibition.