Validation of a method for the analysis of 77 priority persistent organic pollutants in river water by stir bar sorptive extraction in compliance with the European Water Framework Directive.

A multi-residue method for the analysis of semi-volatile organic pollutants in inland groundwater (river water) at ultra-trace levels in compliance with the European Water Framework Directive (WFD) has been developed and validated by stir bar sorptive extraction (SBSE) and thermal desorption coupled with gas chromatography-triple quadrupole mass spectrometry (SBSE-TD-GC-MS/MS(QqQ)). The method includes various families of compounds included in the WFD and other compounds listed as persistent organic pollutants that are banned in the Stockholm Convention of Persistent Organic Pollutants, such as polychlorinated biphenyls, polycyclic aromatics hydrocarbons, and other pesticides not included in the WFD. The method also can be applied for compliance with regional environmental laws. Extraction conditions were optimised in order to analyse simultaneously analytes with very different polarities and octanol-water partition coefficients, which is an important parameter in the optimisation of a SBSE method. The quantification limits (LOQs) obtained ranged from 0.14 to 10 ng L(-1), lower that others presented in previous publications, and complies with the requirement for analytical methods to be used in the analysis of the compounds included in the WFD. Several quality parameters as linearity, trueness and precision were studied with good results, and also uncertainty was estimated. The WFD requires that the level of uncertainty must be lower than 50%, and this requirement was met for all compounds. Precision (in terms of RSD) was lower than 30%, recoveries ranged between 74 and 111%, and determination coefficients were higher than 0.990 for all analytes. Different factors that affect the SBSE procedure were optimised. GC-MS/MS parameters have also been revised. The accuracy of the method was tested participating in a proficiency testing scheme for each group of analytes.

Lupus eritematoso profundo con lipoatrofiasecundaria severa / Lupus erythematosus profundus with severous secondary lipoatrophy

El lupus eritematoso profundo es una variante rara de lupus eritematoso cutáneo que afecta fundamentalmente al tejido celular subcutáneo. Describimosun caso en una mujer de 58 años de edad con lesiones nodulares subcutáneas en nalgas, brazos y espalda. Las lesiones desaparecierondejando una lipoatrofia severa y desfigurante (AU)

Lupus erythematosus profundus is an unusual variant of cutaneous lupus erythematosus that mainly affecting the subcutaneous fat. We report acase on a 58 year-old woman with deep subcutaneous nodules in buttocks, arms and back. The lesions dissappeared leaving severe and desfiguringlipo-atrophy (AU)

Tumoración en la falange distal del tercer dedo de la mano / Tumor on the distal phalanx of the third finger

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[Primary cutaneous anaplastic CD30+ large cell lymphoma]. / Linfoma primario cutáneo anaplásico de células grandes CD30+.

Primary cutaneous anaplastic CD30+ large cell lymphoma (PCALCL) is part of the spectrum of primary cutaneous CD30+ lymphoproliferative disorders together with lymphomatoid papulosis. It affects mainly elderly patients and presents as skin nodules that tend to ulcerate. Histological and immunohistochemical study show the expression of CD30 antigen in more than 75 % of neoplastic cells. Currently it is considered a low grade lymphoma with favourable prognosis and good response to treatments such as local radiotherapy, methotrexate or surgery. We report a 93-year-old patient with ulcerated nodules in her right leg. Histological and immunohistochemical study confirmed the diagnosis of PCALCL, of non-B, non-T origin. The patient was treated with local radiotherapy with progressive resolution of skin nodules and absence of relapse at 6 months follow-up.

Linfoma primario cutáneo anaplásico de células grandes CD301 / Primary cutaneous anaplastic CD30+ large cell lymphoma

El linfoma cutáneo primario anaplásico de células grandes CD30+ (LCPCG) forma parte del espectro de las enfermedades cutáneas primarias linfoproliferativas CD30+, junto a la papulosis linfomatoide. Afecta fundamentalmente a pacientes de edad avanzada, en forma de nódulos cutáneos con tendencia a la ulceración. El estudio histológico e inmunohistoquímico demuestra la expresión del antígeno CD30 en más del 75 % de las células neoplásicas. Actualmente se considera un linfoma de bajo grado de malignidad, con buen pronóstico y buena respuesta a tratamientos como la radioterapia local, el metotrexato o la cirugía. Presentamos un caso en una paciente de 93 años con nódulos ulcerados en la pierna derecha. El estudio histológico e inmunohistoquímico confirmó el diagnóstico de LCPCG CD30+, de origen no T no B. La paciente fue tratada con radioterapia local con resolución paulatina de los nódulos cutáneos y sin mostrar recidiva en los 6 meses de seguimiento

Primary cutaneous anaplastic CD30+ large cell lymphoma (PCALCL) is part of the spectrum of primary cutaneous CD30+ lymphoproliferative disorders together with lymphomatoid papulosis. It affects mainly elderly patients and presents as skin nodules that tend to ulcerate. Histological and immunohistochemical study show the expression of CD30 antigen in more than 75 % of neoplastic cells. Currently it is considered a low grade lymphoma with favourable prognosis and good response to treatments such as local radiotherapy, methotrexate or surgery. We report a 93-year-old patient with ulcerated nodules in her right leg. Histological and immunohistochemical study confirmed the diagnosis of PCALCL, of non-B, non-T origin. The patient was treated with local radiotherapy with progressive resolution of skin nodules and absence of relapse at 6 months follow-up

Anemia de celulas falciformes: Hallazgos en SNC / Sickle cell disease: neurologic findings

La anemia de células falciformes o drepanocítica es una entidad hematológica con un trastorno genético de la hemoglobina claramente establecido, con diferentes manifestaciones clínicas según su órgano blanco con hallazgos típicos en sistema nervioso central. Se presenta un caso de esta entidad en una paciente de 25 años con síntomas neurológicos y hallazgos imaginológicos en RM

Volvulo del ciego: reporte de un caso / Cecal volvulus: report of one case

El vólvulo del ciego es una entidad quirúrgica poco frecuente, con características radiológicas específicas. El diagnóstico clínico es muy pocas veces sospechado antes de la evaluación radiológica, la evaluación imaginológica es importante para detectar complicaciones como perforación o isquemia intestinal. Se reporta un caso con diagnóstico inicial imaginológico, con evolución post-operatoria satisfactoria se revisan los signos radiológicos característicos de esta entidad