RESUMEN
Collodion babies are born with a tight, shiny cast that sheds in a few weeks. After shedding, most patients will display features of autosomal recessive congenital ichthyosis (ARCI) later in life but in up to 10% of cases, the skin eventually becomes normal or only minimally involved, a phenotype called self-healing collodion baby (SHCB), which is considered as ARCI subtype in the 2010 consensus classification of congenital ichthyosis. The term self-improving collodion ichthyosis (SICI) has been proposed for these patients. SHCB/SICI was initially associated with mutations in the gene TGM1. However, some cases showing ALOX12B and ALOXE3 gene mutations have also been reported. We report two cases of SHCB/SICI showing homozygous mutations in the gene CYP4F22.
Asunto(s)
Sistema Enzimático del Citocromo P-450/genética , Eritrodermia Ictiosiforme Congénita/genética , Ictiosis Lamelar/genética , Mutación , Análisis Mutacional de ADN , Femenino , Genotipo , Homocigoto , Humanos , Ictiosis Lamelar/complicaciones , Lactante , Recién Nacido , Masculino , Reacción en Cadena de la PolimerasaRESUMEN
Acral erythema is a frequent cutaneous reaction related to chemotherapy. A patient presented herein developed acral erythema related to cytosine arabinoside treatment and then graft versus host disease (GVHD). Subsequently, worsening of palmar erythema and pain occurred with intravenous cyclosporin infusions.
Asunto(s)
Ciclosporina/efectos adversos , Citarabina/uso terapéutico , Eritema/inducido químicamente , Enfermedad Injerto contra Huésped/tratamiento farmacológico , Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamiento farmacológico , Adulto , Antineoplásicos/uso terapéutico , Erupciones por Medicamentos/etiología , Eritema/terapia , Humanos , Infusiones Intravenosas , Masculino , Metotrexato/uso terapéuticoRESUMEN
Severe combined immunodeficiency includes a group of diseases characterized by different inherited immunological defects. A 4-month-old girl diagnosed with Omenn syndrome, a subtype of severe combined immunodeficiency presenting with generalized erythroderma, was referred to our hospital for an allogeneic stem cell transplantation. Days before transplantation, she developed hyperpigmented macules that increased in number in the following months. As the erythroderma resolved after transplantation, diffuse hypopigmentation was simultaneously noted together with the expansion of hyperpigmented lesions. Cutaneous biopsy samples were taken at different moments, showing features of Omenn syndrome at first, and 2 months later changes consistent with hypopigmentation and repigmentation were observed. Although pigmentary disorders are rarely described in this context, these must be taken into account as a possible alternative diagnosis to graft-versus-host disease and toxicoderma in immunosuppressed patients.
Asunto(s)
Trastornos de la Pigmentación/complicaciones , Trastornos de la Pigmentación/patología , Inmunodeficiencia Combinada Grave/complicaciones , Inmunodeficiencia Combinada Grave/patología , Femenino , Humanos , Lactante , Pigmentación de la PielAsunto(s)
Anticoagulantes/efectos adversos , Heparina/efectos adversos , Enfermedades Cutáneas Vesiculoampollosas/inducido químicamente , Anciano , Anciano de 80 o más Años , Femenino , Hemorragia/inducido químicamente , Humanos , Inyecciones Subcutáneas , Masculino , Enfermedades Cutáneas Vesiculoampollosas/patologíaRESUMEN
Cardiac myxomas are difficult to diagnose, not only because of a lack of specific systemic symptoms but also because, even in those cases presenting with embolic disease, emboli are exceptional. The skin is one of the organs most frequently involved by myxomatous emboli. We report an extraordinary case in which emboli of a cardiac myxoma was present in the skin biopsy, but "camouflaged" among the normal Vater-Pacini corpuscles of the palm of the hand, We also review the existing literature on myxomatous emboli identified in skin biopsies.
Asunto(s)
Neoplasias Cardíacas/patología , Mixoma/patología , Células Neoplásicas Circulantes/patología , Neoplasias Cutáneas/secundario , Piel/patología , Adolescente , Adulto , Biopsia , Procedimientos Quirúrgicos Cardíacos , Femenino , Atrios Cardíacos/patología , Neoplasias Cardíacas/cirugía , Humanos , Masculino , Persona de Mediana Edad , Mixoma/cirugía , Corpúsculos de Pacini/patología , Resultado del TratamientoRESUMEN
Presentamos el caso de un paciente con lesiones purpúricas en regiones acrales. El diagnóstico diferencial de este tipo de lesiones incluye patologías muy variadas, por lo que debe remitirse al paciente de forma urgente/preferente para valoración por un dermatólogo. Se debe realizar un estudio completo que debe incluir analítica con perfil inmunológico y biopsia cutánea. En poco tiempo las lesiones evolucionaron a la forma clínica típica de lupus discoide y respondieron de forma favorable al tratamiento instaurado (AU)
We report a patient with purpuric lesions at acral sites. The differential diagnosis of this type of lesion includes a wide variety diseases, so every patient must be urgently/preferentially referred for a dermatologic evaluation. A complete study must be performed including a blood test with immunological parameters and a skin biopsy. In a very short time the lesions developed into the typical clinical form of discoid lupus, and responded favourably to treatment (AU)