[Effect of an interferon preparation on increasing bacterial sensitivity to antibiotics]. / Vliianie preparata interferona na povyshenie chuvstvitel'nosti bakterii k antibiotikam.

Under the effect of human leukocytic alpha-interferon-II for injections there was observed an increase in sensitivity of bacteria to benzylpenicillin, ristomycin, novobiocin, streptomycin, kanamycin, monomycin and erythromycin. A higher antibacterial effect of the penicillin and erythromycin was recorded only with respect to initially resistant strains of staphylococci. For the antibiotic resistant strains of staphylococci the MICs of the penicillin and erythromycin decreased on the average 17.8 and 208 times (p less than 0.001) respectively. The interferon had no effect on sensitivity of bacteria to chloramphenicol.

[Partial purification and various characteristics of antibacterial factor in preparations of interferon]. / Chastichnaia ochistka i nekotorye kharakteristiki antibakterial'nogo faktora v preparatakh interferona.

A factor showing antibacterial activity was isolated from human alpha-interferon native preparations with affinity chromatography on immobilized cells of staphylococci. The antibacterial activity was found to be stable to the effect of nucleases and heating. Exposure to trypsin activated the antibacterial activity while exposure to pepsin somewhat destroyed it. Growth of the staphylococcal culture resistant to antibiotics was inhibited by the factor.