[Changes in metabolic parameters and glomerular filtration rate in patients with morbid obesity after bariatric surgery].

AIM: To study the effect of weight loss in the short term after bariatric surgery (BO) on metabolic parameters and glomerular filtration rate (GFR) in patients with morbid obesity. MATERIALS AND METHODS: We studied 40 adult (over 18 years) patients with morbid obesity who underwent bariatric surgery. Metabolic indices and calculated GFR according to the CKD-EPI formula in patients before and after bariatric surgery were compared. RESULTS: In the whole group of operated patients, the average body mass index (BMI) after surgery decreased from 45.8 to 30.5 kg/m2. In 11 (92%) patients with impaired carbohydrate metabolism, remission of diabetes mellitus was achieved and sugar-lowering drugs were canceled. In patients with baseline GFR90 ml/min/1.73 m2 after surgery, there is a tendency towards a decrease in GFR, probably due to a decrease in hyperfiltration. In patients with baseline GFR90 ml/min/1.73 m2 after surgery, a statistically significant increase in the level of GFR was noted. The greater metabolic efficacy of combined operations (mini-gastric bypass, biliopancreatic diversion) in relation to the correction of carbohydrate and fat metabolism was revealed. CONCLUSION: Obesity is a modifiable risk factor for decreased kidney function and the progression of chronic kidney disease. Bariatric surgery is an effective treatment for morbid obesity. The study proved the positive effect of weight loss after BO on renal function, including by improving the course of diseases associated with obesity.

[The characteristics of life-style of population of Vladivostok].

Over the past 10 years in the Russian Federation, the health of citizens has been steadily deteriorating: the level of natural population decline is increasing, and life expectancy is decreasing. When analyzing the causes of mortality according to the Federal State Statistics Service, it was revealed that most cases are noncommunicable diseases, their determinants are biological, the state of the environment, medical care, conditions and lifestyle of people. The aim of the study is to identify the degree of commitment of the population of the city of Vladivostok to a healthy lifestyle. A socio-hygienic study was carried out, which included a mass survey of residents of Vladivostok by random sampling. Issues related to the impact of conditions and lifestyles on public health have been studied. Results: Analysis of the research data showed that 19% of men and 6% of women (p<0.05) lacked interest in life. A study of the data showed that currently 66% of women and 44% of men use tobacco products (p<0.05), 53% of women and 59% of men use alcohol (p<0.05), which are factors risk of noncommunicable socially significant diseases. The motivation for maintaining a healthy lifestyle of the population can be strengthened through systematic preventive measures to promote and maintain health.

[Clinical cfficacy of calcium channel blockers slow the third generation of lercanidipine in the treatment of patients with arterial hypertension].

The review describes the classification, mechanisms of action, the effects of calcium channel blockers slow and the clinical benefits of dihydropyridine calcium antagonists, the third generation. Presented modern aspects of clinical pharmacology and research results on the efficacy, safety and organoprotective lercanidipine.